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Amine

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Amine - Free Register to Access Experts & Abstracts

David W C Macmillan - One of the best experts on this subject based on the ideXlab platform.

  • photoredox α vinylation of α amino acids and n aryl Amines
    Journal of the American Chemical Society, 2014
    Co-Authors: Adam Noble, David W C Macmillan
    Abstract:

    A new coupling protocol has been developed that allows the union of vinyl sulfones with photoredox-generated α-amino radicals to provide allylic Amines of broad diversity. Direct C–H vinylations of N-aryl tertiary Amines, as well as decarboxylative vinylations of N-Boc α-amino acids, proceed in high yield and with excellent olefin geometry control. The utility of this new allyl Amine forming reaction has been demonstrated via the syntheses of several natural products and a number of established pharmacophores.

Adam Noble - One of the best experts on this subject based on the ideXlab platform.

  • photoredox α vinylation of α amino acids and n aryl Amines
    Journal of the American Chemical Society, 2014
    Co-Authors: Adam Noble, David W C Macmillan
    Abstract:

    A new coupling protocol has been developed that allows the union of vinyl sulfones with photoredox-generated α-amino radicals to provide allylic Amines of broad diversity. Direct C–H vinylations of N-aryl tertiary Amines, as well as decarboxylative vinylations of N-Boc α-amino acids, proceed in high yield and with excellent olefin geometry control. The utility of this new allyl Amine forming reaction has been demonstrated via the syntheses of several natural products and a number of established pharmacophores.

Hallvard F. Svendsen - One of the best experts on this subject based on the ideXlab platform.

  • kinetics of carbon dioxide absorption into aqueous Amine amino acid salt 3 methylamino propylAmine sarcosine solution
    Chemical Engineering Science, 2011
    Co-Authors: Ugochukwu E. Aronu, Ardi Hartono, Hallvard F. Svendsen
    Abstract:

    Abstract A string of discs contactor apparatus was used to measure the CO 2 absorption kinetics into an unloaded aqueous Amine amino acid salt, 3-(methylamino)propylAmine/sarcosine, SARMAPA solution. The solution was prepared by mixing equinormal proportions of sarcosine, SAR and 3-(methylamino)propylAmine, MAPA. Experiments were carried out for the concentration range 1.0–5.0 kmol m −3 and for temperatures 25–62 °C. The termolecular mechanism was applied to interpret the experimental data after correcting for non-idealities from the ionic strength using an ionic correction factor. A model correlation without the ionic strength correction was found not to give a good fit to the experimental data. The reaction rate constant for aqueous SARMAPA was determined and found to be comparable to values for Amines. It increases significantly with temperature and concentration. The reaction rate constant for water is higher in the SARMAPA system than in Amine systems indicating that water contributes significantly to the overall absorption rate and more than in Amine systems. The reaction order with respect to the amino acid salt, SARMAPA, concentration varies from 1.06 to 1.43 with an average value of 1.21. A simplified approach applied to the complex speciation chemistry of the Amine amino acid salt, AAAS, system gave a good representation of the experimentally observed kinetic rate constant.

  • Kinetics of carbon dioxide absorption into aqueous Amine amino acid salt: 3-(methylamino)propylAmine/sarcosine solution
    Chemical Engineering Science, 2011
    Co-Authors: Ugochukwu E. Aronu, Ardi Hartono, Hallvard F. Svendsen
    Abstract:

    Abstract A string of discs contactor apparatus was used to measure the CO 2 absorption kinetics into an unloaded aqueous Amine amino acid salt, 3-(methylamino)propylAmine/sarcosine, SARMAPA solution. The solution was prepared by mixing equinormal proportions of sarcosine, SAR and 3-(methylamino)propylAmine, MAPA. Experiments were carried out for the concentration range 1.0–5.0 kmol m −3 and for temperatures 25–62 °C. The termolecular mechanism was applied to interpret the experimental data after correcting for non-idealities from the ionic strength using an ionic correction factor. A model correlation without the ionic strength correction was found not to give a good fit to the experimental data. The reaction rate constant for aqueous SARMAPA was determined and found to be comparable to values for Amines. It increases significantly with temperature and concentration. The reaction rate constant for water is higher in the SARMAPA system than in Amine systems indicating that water contributes significantly to the overall absorption rate and more than in Amine systems. The reaction order with respect to the amino acid salt, SARMAPA, concentration varies from 1.06 to 1.43 with an average value of 1.21. A simplified approach applied to the complex speciation chemistry of the Amine amino acid salt, AAAS, system gave a good representation of the experimentally observed kinetic rate constant.

Arminda Alves - One of the best experts on this subject based on the ideXlab platform.

Matthias Höhne - One of the best experts on this subject based on the ideXlab platform.

  • Bacillus anthracis ω-amino acid:pyruvate transaminase employs a different mechanism for dual substrate recognition than other Amine transaminases
    Applied Microbiology and Biotechnology, 2016
    Co-Authors: Fabian Steffen-munsberg, Philipp Matzel, Miriam A. Sowa, Per Berglund, Uwe T. Bornscheuer, Matthias Höhne
    Abstract:

    Understanding the metabolic potential of organisms or a bacterial community based on their (meta) genome requires the reliable prediction of an enzyme’s function from its amino acid sequence. Besides a remarkable development in prediction algorithms, the substrate scope of sequences with low identity to well-characterized enzymes remains often very elusive. From a recently conducted structure function analysis study of PLP-dependent enzymes, we identified a putative transaminase from Bacillus anthracis (Ban-TA) with the crystal structure 3N5M (deposited in the protein data bank in 2011, but not yet published). The active site residues of Ban-TA differ from those in related (class III) transaminases, which thereby have prevented function predictions. By investigating 50 substrate combinations its Amine and ω-amino acid:pyruvate transaminase activity was revealed. Even though Ban-TA showed a relatively narrow Amine substrate scope within the tested substrates, it accepts 2-propylAmine, which is a prerequisite for industrial asymmetric Amine synthesis. Structural information implied that the so-called dual substrate recognition of chemically different substrates (i.e. Amines and amino acids) differs from that in formerly known enzymes. It lacks the normally conserved ‘flipping’ arginine, which enables dual substrate recognition by its side chain flexibility in other ω-amino acid:pyruvate transaminases. Molecular dynamics studies suggested that another arginine (R162) binds ω-amino acids in Ban-TA, but no side chain movements are required for Amine and amino acid binding. These results, supported by mutagenesis studies, provide functional insights for the B. anthracis enzyme, enable function predictions of related proteins, and broadened the knowledge regarding ω-amino acid and Amine converting transaminases.