The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Bernhard K Keppler - One of the best experts on this subject based on the ideXlab platform.
-
the intramolecular ligand exchange reaction of sp 4 2 dichlorobis 2 hydroxyethylamine platinum ii and oc 6 22 tetrachlorobis 2 hydroxyethylamine platinum iv a1h and15n 1h HMQC nmr study
European Journal of Inorganic Chemistry, 2001Co-Authors: Markus Galanski, Wolfgang Zimmermann, Christian Baumgartner, Bernhard K KepplerAbstract:The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) (1) and (OC-6-22)-tetrachlororbis(2-hydroxyethylamine)platinum(IV) (2) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5′-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(II) (3) and (OC-6-31)-trichloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(IV) (4) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1H and 2D 15N,1H-HMQC NMR experiments and the crystal structure determination of 4.
Markus Galanski - One of the best experts on this subject based on the ideXlab platform.
-
the intramolecular ligand exchange reaction of sp 4 2 dichlorobis 2 hydroxyethylamine platinum ii and oc 6 22 tetrachlorobis 2 hydroxyethylamine platinum iv a1h and15n 1h HMQC nmr study
European Journal of Inorganic Chemistry, 2001Co-Authors: Markus Galanski, Wolfgang Zimmermann, Christian Baumgartner, Bernhard K KepplerAbstract:The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) (1) and (OC-6-22)-tetrachlororbis(2-hydroxyethylamine)platinum(IV) (2) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5′-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(II) (3) and (OC-6-31)-trichloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(IV) (4) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1H and 2D 15N,1H-HMQC NMR experiments and the crystal structure determination of 4.
Wolfgang Zimmermann - One of the best experts on this subject based on the ideXlab platform.
-
the intramolecular ligand exchange reaction of sp 4 2 dichlorobis 2 hydroxyethylamine platinum ii and oc 6 22 tetrachlorobis 2 hydroxyethylamine platinum iv a1h and15n 1h HMQC nmr study
European Journal of Inorganic Chemistry, 2001Co-Authors: Markus Galanski, Wolfgang Zimmermann, Christian Baumgartner, Bernhard K KepplerAbstract:The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) (1) and (OC-6-22)-tetrachlororbis(2-hydroxyethylamine)platinum(IV) (2) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5′-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(II) (3) and (OC-6-31)-trichloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(IV) (4) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1H and 2D 15N,1H-HMQC NMR experiments and the crystal structure determination of 4.
Christian Baumgartner - One of the best experts on this subject based on the ideXlab platform.
-
the intramolecular ligand exchange reaction of sp 4 2 dichlorobis 2 hydroxyethylamine platinum ii and oc 6 22 tetrachlorobis 2 hydroxyethylamine platinum iv a1h and15n 1h HMQC nmr study
European Journal of Inorganic Chemistry, 2001Co-Authors: Markus Galanski, Wolfgang Zimmermann, Christian Baumgartner, Bernhard K KepplerAbstract:The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) (1) and (OC-6-22)-tetrachlororbis(2-hydroxyethylamine)platinum(IV) (2) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5′-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(II) (3) and (OC-6-31)-trichloro(2-ethanolatoamine-κ2N,O)(2-hydroxyethylamine)platinum(IV) (4) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1H and 2D 15N,1H-HMQC NMR experiments and the crystal structure determination of 4.
R Kaptein - One of the best experts on this subject based on the ideXlab platform.
-
solution structure of the pou specific dna binding domain of oct 1
Nature, 1993Co-Authors: Niek Dekker, Rolf Boelens, Peter C Verrijzer, Peter C Van Der Vliet, R KapteinAbstract:THE transcription factor Oct-1 belongs to a family containing a POU DNA-binding domain. This bipartite domain is composed of a POU-specific domain (POUs) and a POU-homeodomain (POUhd) connected by a flexible linker. The left half of the optimal POU binding site, the octamer ATGCAAAT, is recognized by POUs and the right half by POUhd. We have determined the solution structure of POUs by nuclear magnetic resonance. It consists of four α-helices connected by short loops. Helices I and IV are in a parallel coiled-coil arrangement. The folding topology appears to be similar to that of the bacteriophage Λ-represser and 434 represser. For the well defined parts of the protein (residues 1–71), the average root-mean square deviation for the backbone atoms is 0.9 A. Based on the observed selective exchange broadening in the (15N, 1H)-HMQC (heteronuclear multiple quantum coherence) spectrum of the POUs–DNA complex we conclude that DNA-binding is mediated by helix III. We propose a model for the POU–DNA complex in which both recognition helices from the two subdomains have adjacent positions in the major groove.
