The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Henri Doucet - One of the best experts on this subject based on the ideXlab platform.
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Direct Access to 2-(Hetero)arylated Pyridines from 6-Substituted 2-Bromopyridines via Phosphine-Free Palladium-Catalyzed C—H Bond Arylations: The Importance of the C6 Substituent.
ChemInform, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:An environmentally benign C—H bond activation/arylation of 5-membered heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines provides 2-(hetero)arylpyridines.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C-H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C-H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of sym. and unsym. 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C-Br bond cleavage.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C–H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C–H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of symmetrical and unsymmetrical 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C–Br bond cleavage.
Peter J. Steel - One of the best experts on this subject based on the ideXlab platform.
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Full Paper Synthesis and Characterisation of Eight Isomeric Bis(2-pyridyloxy)naphthalenes
2015Co-Authors: Brendan J. O’keefe, Peter J. SteelAbstract:Abstract: Eight isomeric bis(2-pyridyloxy)naphthalenes have been prepared from reactions of 2-Bromopyridine with the appropriate dihydroxynaphthalene and the products fully characterised by 1- and 2-D NMR spectroscopy
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Synthesis and Characterisation of Eight Isomeric Bis(2-pyridyloxy)naphthalenes
Molecules (Basel Switzerland), 2006Co-Authors: Brendan J. O'keefe, Peter J. SteelAbstract:Eight isomeric bis(2-pyridyloxy)naphthalenes have been prepared from reactions of 2-Bromopyridine with the appropriate dihydroxynaphthalene and the products fully characterised by 1- and 2-D NMR spectroscopy.
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Self-Assembly and X-ray Structure of a Dimetalloparacyclophane Incorporating a pi-pi Stacked Subunit.
Inorganic chemistry, 1996Co-Authors: Chris M. Hartshorn, Peter J. SteelAbstract:1,4-Bis(2-pyridoxy)benzene, readily prepared from hydroquinone and 2-Bromopyridine, reacts with silver nitrate to produce a novel [2 + 2] complex, which is shown, by an X-ray crystal structure dete...
Wided Hagui - One of the best experts on this subject based on the ideXlab platform.
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Direct Access to 2-(Hetero)arylated Pyridines from 6-Substituted 2-Bromopyridines via Phosphine-Free Palladium-Catalyzed C—H Bond Arylations: The Importance of the C6 Substituent.
ChemInform, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:An environmentally benign C—H bond activation/arylation of 5-membered heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines provides 2-(hetero)arylpyridines.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C-H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C-H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of sym. and unsym. 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C-Br bond cleavage.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C–H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C–H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of symmetrical and unsymmetrical 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C–Br bond cleavage.
Belén Abarca - One of the best experts on this subject based on the ideXlab platform.
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Deprotonative Magnesation and Cadmation of [1,2,3]Triazolo[1,5-a]pyridines.
ChemInform, 2009Co-Authors: Ghenia Bentabed-ababsa, Fernando Blanco, Aicha Derdour, Florence Mongin, François Trécourt, Guy Quéguiner, Rafael Ballesteros, Belén AbarcaAbstract:International audience[1,2,3]Triazolo[1,5-a]pyridine and 3-substituted derivatives were regioselectively metalated at the 7 position using either Bu3MgLi or (TMP)3CdLi, the former at -10 °C and the latter at room temperature. The lithium arylmagnesates (R = H, Me, Ph) proved to react with iodine (34-75%) or 3,4,5- trimethoxybenzaldehyde (32-51%). Attempts to obtain the cross-couplings products using 2- bromopyridine under palladium catalysis failed, a result attributed to the low stability of these compounds. The corresponding lithium arylzincates reacted in 17 to 60% yield under the same reaction conditions. The lithium arylcadmates were either trapped with iodine (38-76%, R = H, Me, Ph, CN, 2- thienyl) or involved in palladium-catalyzed cross-coupling reactions with 2-Bromopyridine (26-67%, R = H, Me, Ph). For R = 2-pyridyl, 3-(6-iodo-2-pyridyl)-[1,2,3]triazolo[1,5-a]pyridine was isolated in 73% yield. (TMP)3CdLi also proved suitable for the clean dideprotonation of two substrates (R = H, 2- thienyl), a result demonstrated by quenching with iodine (66-75%)
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Deprotonative magnesation and cadmation of [1,2,3]triazolo[1,5-a]pyridines
Journal of Organic Chemistry, 2009Co-Authors: Ghenia Bentabed-ababsa, Fernando Blanco, Aicha Derdour, Florence Mongin, François Trécourt, Guy Quéguiner, Rafael Ballesteros, Belén AbarcaAbstract:[1,2,3]Triazolo[1,5-a]pyridine and 3-substituted derivatives were regioselectively metalated at the 7 position using either Bu3MgLi or (TMP)3CdLi, the former at -10 °C and the latter at room temperature. The lithium arylmagnesates (R = H, Me, Ph) proved to react with iodine (34-75%) or 3,4,5- trimethoxybenzaldehyde (32-51%). Attempts to obtain the cross-couplings products using 2- bromopyridine under palladium catalysis failed, a result attributed to the low stability of these compounds. The corresponding lithium arylzincates reacted in 17 to 60% yield under the same reaction conditions. The lithium arylcadmates were either trapped with iodine (38-76%, R = H, Me, Ph, CN, 2- thienyl) or involved in palladium-catalyzed cross-coupling reactions with 2-Bromopyridine (26-67%, R = H, Me, Ph). For R = 2-pyridyl, 3-(6-iodo-2-pyridyl)-[1,2,3]triazolo[1,5-a]pyridine was isolated in 73% yield. (TMP)3CdLi also proved suitable for the clean dideprotonation of two substrates (R = H, 2- thienyl), a result demonstrated by quenching with iodine (66-75%).
Jean-françois Soulé - One of the best experts on this subject based on the ideXlab platform.
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Direct Access to 2-(Hetero)arylated Pyridines from 6-Substituted 2-Bromopyridines via Phosphine-Free Palladium-Catalyzed C—H Bond Arylations: The Importance of the C6 Substituent.
ChemInform, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:An environmentally benign C—H bond activation/arylation of 5-membered heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines provides 2-(hetero)arylpyridines.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C-H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C-H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of sym. and unsym. 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C-Br bond cleavage.
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Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-Bromopyridines via phosphine-free palladium-catalyzed C–H bond arylations: the importance of the C6 substituent
RSC Advances, 2016Co-Authors: Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean-françois Soulé, Henri DoucetAbstract:A phosphine-free palladium catalytic system was found to be very active to promote C–H bond activation/arylation of 5-membered ring heterocycles or electron-deficient arenes with 6-substituted 2-Bromopyridines, providing a general, straightforward and environmentally benign synthetic approach to a broad variety of 2-(hetero)arylpyridines. The reactivity of 2-Bromopyridines is strongly dependent on the substituent at the C6 position. Several C6 substituents such as Br, CF3, CH3, CHO, or morpholine have been employed. Moreover, the use of 2,6-dibromopyridine as the coupling partner allowed the synthesis in high yields of symmetrical and unsymmetrical 2,6-di(hetero)arylpyridines, as well as 2-heteroarylpyridines after the C–Br bond cleavage.