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2-Methoxyethanol

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Boguslawa Budziszewska – One of the best experts on this subject based on the ideXlab platform.

  • potential neurotoxic effect of ethylene glycol ethers mixtures
    Pharmacological Reports, 2013
    Co-Authors: Bartosz Pomierny, Andrzej Starek, Weronika Krzyzanowska, Beata Starekświechowicz, Irena Smaga, Lucyna Pomiernychamiolo, Magdalena Regulska, Boguslawa Budziszewska

    Abstract:

    Abstract Background Ethylene glycol ethers (EGEs) are widely used as mixtures in various industrial processes and in many household products. 2-Methoxyethanol and 2-ethoxyethanol primarily exert gonadotoxic effect, while 2-butoxyethanol and 2-isopropoxyethanol have potent hemolytic activity. EGEs can cross the blood-brain barrier, but their potential neurodegenerative action in vivo has not been investigated, yet. In the present work, we examined potential adverse effects of EGEs on some selected brain structures. Methods A mixture of two compounds: one with stronger hydrophilic properties (2-Methoxyethanol or 2-ethoxyethanol) and the second more lipophilic (2-butoxyethanol or 2-isopropoxyethanol) were administered sc for 4 weeks. Total antioxidant capacity, lipid peroxidation and caspase-3 activity were determined in the frontal cortex and hippocampus. Results It has been found that 4-week administration of a mixture of two EGEs, with various intensity, decreased total antioxidant capacity, enhanced lipid peroxidation and increased caspase-3 activity in the frontal cortex and hippocampus of Wistar rat. Conclusion The obtained results suggested that EGEs exerted adverse effects on the CNS cells and may contribute in pathogenesis of neurodegenerative disorders.

  • effects of ethylene glycol ethers on cell viability in the human neuroblastoma sh sy5y cell line
    Pharmacological Reports, 2010
    Co-Authors: Magdalena Regulska, Bartosz Pomierny, Boguslawa Budziszewska, Andrzej Starek, Agnieszka Bastakaim, Malgorzata Filip, Wladyslaw Lason

    Abstract:

    Abstract Ethylene glycol ethers (EGEs) are a class of chemicals used extensively in the manufacture of a wide range of domestic and industrial products, which may result in human exposure and toxicity. Hematologic and reproductive toxicity of EGEs are well known whereas their action on neuronal cell viability has not been studied so far. In the present study, we investigated the effects of some EGEs on cell viability and on the hydrogen peroxide-induced damage in the human neuroblastoma (SH-SY5Y) cells. It has been found that 2-phenoxyethanol in a concentration-dependent manner (5–25 mM, 24 h) increased the basal and H 2 O 2 -induced lactate dehydrogenase (LDH) release and 3-[4,5-dimethylthiazol-2-yl]2,5-diphenyl tetrazolium bromide (MTT) reduction. 2-Butoxyethanol given alone did not affect LDH release and MTT reduction but concentration-dependently enhanced the cytotoxic effect of H 2 O 2 .2-Isopropoxyethanol significantly and concentration-dependently (1–25 mM) increased the basal LDH release and attenuated MTT reduction, but did not potentiate the cytotoxic effect of H 2 O 2 . Contrary to this, 2-Methoxyethanol did not show a cytotoxic effect while 2-ethoxyethanol at high concentrations intensified the hydrogen peroxide action. This study demonstrated that among the EGEs studied, 2-phenoxyethanol showed the most consistent cytotoxic effect on neurons in in vitro conditions and enhanced the hydrogen peroxide action. 2-Isopropoxyethanol had also a potent cytotoxic effect, but it did not enhance the hydrogen peroxide action, whereas 2-butoxyethanol only potentiated cytotoxic effect of H 2 O 2 . It is concluded that the results of the present study should be confirmed in in vivo conditions and that some EGEs, especially 2-phenoxyethanol, 2-butoxyethanol and 2-isopropoxyethanol, may be responsible for initiation or exacerbation of neuronal cell damage.

Purushottam Haldar – One of the best experts on this subject based on the ideXlab platform.

  • Electrical Conductances of Tetraethylammonium Bromide and Tetrapropylammonium Bromide in 2-Ethoxyethanol (1) + Water (2) Mixtures at (308.15, 313.15, 318.15, and 323.15) K
    Journal of Chemical & Engineering Data, 2005
    Co-Authors: Purushottam Haldar

    Abstract:

    The electrical conductances of the solutions of tetraethylammonium bromide (Et4NBr) and tetrapropylammonium bromide (Pr 4 NBr) in 2-ethoxyethanol (1) + water (2) mixed solvent media containing 0.25, 50, and 0.75 mass fractions of 2-ethoxyethanol (ω 1 ) have been reported at (308.15, 313.15, 318.15, and 323.15) K. The conductance data have been analyzed by the 1978 Fuoss conductance-concentration equation in terms of the limiting molar conductance (A°), the association constant (K A ), and the association diameter (R). These two electrolytes are found to exist essentially as free ions in the solvent mixtures with ω 1 = 0.25 and 50 over the entire temperature range; however, slight ionic association was observed in the mixed solvent medium richest in 2-ethoxyethanol. The electrostatic ion-solvent interaction is found to be very weak for the tetraalkylammonium ions in the aqueous 2-ethoxyethanol mixtures investigated.

  • electrical conductances of tetraethylammonium bromide and tetrapropylammonium bromide in 2 ethoxyethanol 1 water 2 mixtures at 308 15 313 15 318 15 and 323 15 k
    Journal of Chemical & Engineering Data, 2005
    Co-Authors: Purushottam Haldar

    Abstract:

    The electrical conductances of the solutions of tetraethylammonium bromide (Et4NBr) and tetrapropylammonium bromide (Pr 4 NBr) in 2-ethoxyethanol (1) + water (2) mixed solvent media containing 0.25, 50, and 0.75 mass fractions of 2-ethoxyethanol (ω 1 ) have been reported at (308.15, 313.15, 318.15, and 323.15) K. The conductance data have been analyzed by the 1978 Fuoss conductance-concentration equation in terms of the limiting molar conductance (A°), the association constant (K A ), and the association diameter (R). These two electrolytes are found to exist essentially as free ions in the solvent mixtures with ω 1 = 0.25 and 50 over the entire temperature range; however, slight ionic association was observed in the mixed solvent medium richest in 2-ethoxyethanol. The electrostatic ion-solvent interaction is found to be very weak for the tetraalkylammonium ions in the aqueous 2-ethoxyethanol mixtures investigated.

Lovely Sarkar – One of the best experts on this subject based on the ideXlab platform.

  • density viscosity refractive index and ultrasonic speed of binary mixtures of 1 3 dioxolane with 2 methoxyethanol 2 ethoxyethanol 2 butoxyethanol 2 propylamine and cyclohexylamine
    Journal of Chemical & Engineering Data, 2009
    Co-Authors: Lovely Sarkar

    Abstract:

    The excess molar volumes (VE) and viscosity deviations (Δη) have been calculated from experimental density (ρ) and viscosity (η) data of the binary mixtures of 1,3-dioxolane (DO) with 2-Methoxyethanol (ME), 2-ethoxyethanol (EE), 2-butoxyethanol (BE), 2-propylamine (PA), and cyclohexylamine (CA) measured over the entire range of composition at 298.15 K. Moreover, deviations in isentropic compressibility (ΔKS) and molar refraction (ΔR) have been calculated from ultrasonic speed of sounds (u) and refractive indices (nD) of the mixtures, respectively. The excess or deviation properties were fitted to the Redlich−Kister polynomial equation to derive the adjustable parameters (Ak) and corresponding standard deviations (σ).