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20-Hydroxyecdysone

The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform

Victor N Odinokov – 1st expert on this subject based on the ideXlab platform

  • 7α alkylation and 7 7 bis alkylation of 20 hydroxyecdysone with propargyl bromide in a lithium ammonia solution and catalytic reductive spirocyclization of 7 7 bis 2 propyn 1 yl 14 deoxy δ8 14 20 hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution and catalytic reductive spirocyclization of 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ8(14)-20-Hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • Stereospecific 7α-alkylation of 20-Hydroxyecdysone in a lithium-ammonia solution.
    Steroids, 2015
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Elvira R. Zaripova, Ekaterina S. Mescheryakova, Oleg S. Mozgovoi, Victor N Odinokov

    Abstract:

    Abstract The reaction of 20-Hydroxyecdysone with methyl or ethyl iodide or allyl bromide in a lithium–ammonia solution results in stereospecific 7α-alkylation to give 7α-methyl-, 7α-ethyl-, and 7α-allyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysones, respectively. By catalytic hydrogenation (Pd-C/MeOH), the 7α-allyl derivative was converted to 7α- n -propyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysone.

I V Galyautdinov – 2nd expert on this subject based on the ideXlab platform

  • 7α alkylation and 7 7 bis alkylation of 20 hydroxyecdysone with propargyl bromide in a lithium ammonia solution and catalytic reductive spirocyclization of 7 7 bis 2 propyn 1 yl 14 deoxy δ8 14 20 hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution and catalytic reductive spirocyclization of 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ8(14)-20-Hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • Stereospecific 7α-alkylation of 20-Hydroxyecdysone in a lithium-ammonia solution.
    Steroids, 2015
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Elvira R. Zaripova, Ekaterina S. Mescheryakova, Oleg S. Mozgovoi, Victor N Odinokov

    Abstract:

    Abstract The reaction of 20-Hydroxyecdysone with methyl or ethyl iodide or allyl bromide in a lithium–ammonia solution results in stereospecific 7α-alkylation to give 7α-methyl-, 7α-ethyl-, and 7α-allyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysones, respectively. By catalytic hydrogenation (Pd-C/MeOH), the 7α-allyl derivative was converted to 7α- n -propyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysone.

Leonard M. Khalilov – 3rd expert on this subject based on the ideXlab platform

  • 7α alkylation and 7 7 bis alkylation of 20 hydroxyecdysone with propargyl bromide in a lithium ammonia solution and catalytic reductive spirocyclization of 7 7 bis 2 propyn 1 yl 14 deoxy δ8 14 20 hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution and catalytic reductive spirocyclization of 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ8(14)-20-Hydroxyecdysone
    Steroids, 2016
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Victor N Odinokov

    Abstract:

    Abstract 7α-Alkylation and 7,7-bis-alkylation of 20-Hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ 8(14) –20-Hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd–C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups.

  • Stereospecific 7α-alkylation of 20-Hydroxyecdysone in a lithium-ammonia solution.
    Steroids, 2015
    Co-Authors: I V Galyautdinov, Zarema R Khairullina, Valery P Sametov, Z. S. Muslimov, Leonard M. Khalilov, Elvira R. Zaripova, Ekaterina S. Mescheryakova, Oleg S. Mozgovoi, Victor N Odinokov

    Abstract:

    Abstract The reaction of 20-Hydroxyecdysone with methyl or ethyl iodide or allyl bromide in a lithium–ammonia solution results in stereospecific 7α-alkylation to give 7α-methyl-, 7α-ethyl-, and 7α-allyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysones, respectively. By catalytic hydrogenation (Pd-C/MeOH), the 7α-allyl derivative was converted to 7α- n -propyl-14-deoxy-Δ 8(14) –20-Hydroxyecdysone.