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Bendfort Rock Ranger District – One of the best experts on this subject based on the ideXlab platform.

Andrew Allen – One of the best experts on this subject based on the ideXlab platform.

  • PreBötzinger complex neurons drive respiratory modulation of blood pressure and 1 heart rate 2 3
    eLife, 2020
    Co-Authors: Clément Menuet, Angela Connelly, Jaspreet Bassi, Mariana Melo, Jessica Kamar, Natasha Kumar, Stuart Mcdougall, Simon Mcmullan, Andrew Allen
    Abstract:

    18 Heart rate and blood pressure oscillate in phase with respiratory activity. A component of 19 these oscillations is generated centrally, with respiratory neurons entraining the activity of 20 pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of 21 optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we 22 demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for 23 inspiratory rhythm generation, directly modulate cardiovascular activity. Specifically, 24 inhibitory preBötC neurons modulate cardiac parasympathetic neuron activity whilst 25 excitatory preBötC neurons modulate sympathetic vasomotor neuron activity, generating 26 heart rate and blood pressure oscioscillations in phase with respiration. Our data reveal yet more 27 functions entrained to the activity of the preBötC, with a role in generating cardiorespiratory 28 oscillations. The findings have implications for cardiovascular pathologies, such as 29 hypertension and heart failure, where respiratory entrainment of heart rate is diminished and 30 respiratory entrainment of blood pressure exaggerated. 31 32

Clément Menuet – One of the best experts on this subject based on the ideXlab platform.

  • PreBötzinger complex neurons drive respiratory modulation of blood pressure and 1 heart rate 2 3
    eLife, 2020
    Co-Authors: Clément Menuet, Angela Connelly, Jaspreet Bassi, Mariana Melo, Jessica Kamar, Natasha Kumar, Stuart Mcdougall, Simon Mcmullan, Andrew Allen
    Abstract:

    18 Heart rate and blood pressure oscillate in phase with respiratory activity. A component of 19 these oscillations is generated centrally, with respiratory neurons entraining the activity of 20 pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of 21 optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we 22 demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for 23 inspiratory rhythm generation, directly modulate cardiovascular activity. Specifically, 24 inhibitory preBötC neurons modulate cardiac parasympathetic neuron activity whilst 25 excitatory preBötC neurons modulate sympathetic vasomotor neuron activity, generating 26 heart rate and blood pressure oscillations in phase with respiration. Our data reveal yet more 27 functions entrained to the activity of the preBötC, with a role in generating cardiorespiratory 28 oscillations. The findings have implications for cardiovascular pathologies, such as 29 hypertension and heart failure, where respiratory entrainment of heart rate is diminished and 30 respiratory entrainment of blood pressure exaggerated. 31 32

S. J. Shenoy – One of the best experts on this subject based on the ideXlab platform.

  • Condensed heterotricycles: Pyrido(1,2,3-de)(1,4)benzoxazines, pyrido(1,2,3-ef)(1,5)benzoxazepines and pyrido(1,2,3-fg)(1,6) benzoxazocines
    Proceedings of the Indian Academy of Sciences – Chemical Sciences, 1992
    Co-Authors: K. Nagarajan, A. Nagana Goud, R. K. Shah, S. J. Shenoy
    Abstract:

    Cyclization of N-(2-haloacyl)-8-hydroxy-l,2,3,4-tetrahydroqumolines 4 – 7 and 9 with alkali affords pyridobenzoxazinones 21 – 24 and 26 respectively and of the 4-chlorobutyramide 13 with NaH, the benzoxazocinone 31 . Exposure of 3-chloropropionamide 12 to NaH affords acrylamide 15 , benzoxazepinone 28 or methyl benzoxazinone 22 or mixtures thereof under various conditions. 28 undergoes rapid base-catalysed ring contraction to 22 . NaH-catalysed ring closure of acrylamide 15 affords mixtures of 22 and 28 , while from the crotonamides 16 and 17 , the methylbenzoxazepinones 29 and 30 are obtained preponderantly, the former amide yielding only traces of the ethyl benzoxazinone 23 . 29 shows no propensity for ring contraction to give 23 . The cinnamoyl derivatives 18 , 19 and 20 are cyclized to benzyl benzoxazinones 24 , 27 and 25 , respectively. The intermediacy of the phenyl benzoxazepinone 39 in the formation of 24 has been established by deuteration studies. Benzylidene benzoxazinone 41 is obtained from dibromocinnamamide 14 and propiolamide 40 . Dichloracetamides 8 and 10 undergo interesting ring closure to compounds 45 – 54 upon treatment with amines. The course of electrophilic reactions of the lactams depends upon the ring size.

  • Condensed heterotricycles: Pyrido(1,2,3-de)(1,4)benzoxazines, pyrido(1,2,3-ef)(1,5)benzoxazepines and pyrido(1,2,3-fg)(1,6) benzoxazocines
    Proceedings of the Indian Academy of Sciences – Chemical Sciences, 1992
    Co-Authors: K. Nagarajan, A. Nagana Goud, R. K. Shah, V. Ranga Rao, S. J. Shenoy
    Abstract:

    Cyclization of N-(2-haloacyl)-8-hydroxy-l,2,3,4-tetrahydroqumolines 4 – 7 and 9 with alkali affords pyridobenzoxazinones 21 – 24 and 26 respectively and of the 4-chlorobutyramide 13 with NaH, the benzoxazocinone 31 . Exposure of 3-chloropropionamide 12 to NaH affords acrylamide 15 , benzoxazepinone 28 or methyl benzoxazinone 22 or mixtures thereof under various conditions. 28 undergoes rapid base-catalysed ring contraction to 22 . NaH-catalysed ring closure of acrylamide 15 affords mixtures of 22 and 28 , while from the crotonamides 16 and 17 , the methylbenzoxazepinones 29 and 30 are obtained preponderantly, the former amide yielding only traces of the ethyl benzoxazinone 23 . 29 shows no propensity for ring contraction to give 23 . The cinnamoyl derivatives 18 , 19 and 20 are cyclized to benzyl benzoxazinones 24 , 27 and 25 , respectively. The intermediacy of the phenyl benzoxazepinone 39 in the formation of 24 has been established by deuteration studies. Benzylidene benzoxazinone 41 is obtained from dibromocinnamamide 14 and propiolamide 40 . Dichloracetamides 8 and 10 undergo interesting ring closure to compounds 45 – 54 upon treatment with amines. The course of electrophilic reactions of the lactams depends upon the ring size.

Angela Connelly – One of the best experts on this subject based on the ideXlab platform.

  • PreBötzinger complex neurons drive respiratory modulation of blood pressure and 1 heart rate 2 3
    eLife, 2020
    Co-Authors: Clément Menuet, Angela Connelly, Jaspreet Bassi, Mariana Melo, Jessica Kamar, Natasha Kumar, Stuart Mcdougall, Simon Mcmullan, Andrew Allen
    Abstract:

    18 Heart rate and blood pressure oscillate in phase with respiratory activity. A component of 19 these oscillations is generated centrally, with respiratory neurons entraining the activity of 20 pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of 21 optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we 22 demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for 23 inspiratory rhythm generation, directly modulate cardiovascular activity. Specifically, 24 inhibitory preBötC neurons modulate cardiac parasympathetic neuron activity whilst 25 excitatory preBötC neurons modulate sympathetic vasomotor neuron activity, generating 26 heart rate and blood pressure oscillations in phase with respiration. Our data reveal yet more 27 functions entrained to the activity of the preBötC, with a role in generating cardiorespiratory 28 oscillations. The findings have implications for cardiovascular pathologies, such as 29 hypertension and heart failure, where respiratory entrainment of heart rate is diminished and 30 respiratory entrainment of blood pressure exaggerated. 31 32