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Bernhard Lippert - One of the best experts on this subject based on the ideXlab platform.
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cis diammineplatinum ii forms a macrochelate with 2 deoxycytidine 5 monophosphate dcmp 2 reactivity and acid base properties of cis 2*PT nh 3 2 dcmp
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K<0.6). The cis-2*PT(NH3)2(dCMP) complex reacts with nucleosides and nucleotides (L′) by losing its chelate structure and forming mixed ligand complexes, cis-2*PT(NH3)2(dCMP)(L′); this means that the phosphate group is released from the coordination sphere of 2*PT(II), indicating that the 2*PT(II)-O(phosphate) bond is not very strong.
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Cis -diammineplatinum(II) forms a macrochelate with 2′-deoxycytidine 5′-monophosphate (dCMP 2– )! Reactivity and acid-base properties of cis -2*PT(NH 3 ) 2 (dCMP)
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K
Gerda Oswald - One of the best experts on this subject based on the ideXlab platform.
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cis diammineplatinum ii forms a macrochelate with 2 deoxycytidine 5 monophosphate dcmp 2 reactivity and acid base properties of cis 2*PT nh 3 2 dcmp
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K<0.6). The cis-2*PT(NH3)2(dCMP) complex reacts with nucleosides and nucleotides (L′) by losing its chelate structure and forming mixed ligand complexes, cis-2*PT(NH3)2(dCMP)(L′); this means that the phosphate group is released from the coordination sphere of 2*PT(II), indicating that the 2*PT(II)-O(phosphate) bond is not very strong.
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Cis -diammineplatinum(II) forms a macrochelate with 2′-deoxycytidine 5′-monophosphate (dCMP 2– )! Reactivity and acid-base properties of cis -2*PT(NH 3 ) 2 (dCMP)
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K
Konrad Seppelt - One of the best experts on this subject based on the ideXlab platform.
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the platinum ii salt 2*PT h2o 4 sbf6 2
ChemInform, 2011Co-Authors: Konrad SeppeltAbstract:Title compound (III) crystallizes in the triclinic space group P with Z = 1 (single crystal XRD at -140 °C).
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the platinum ii salt 2*PT h2o 4 sbf6 2
Zeitschrift für anorganische und allgemeine Chemie, 2010Co-Authors: Konrad SeppeltAbstract:The platinum(II) salt 2*PT(H2O)4(SbF6)2 is a stable compound. In the solid state the compound consists of isolated 2*PT(H2O)42+ cations and SbF6– anions. Space group P, Z = 1, lattice dimensions at 133 K: a = 503.7(2), b = 783.4(2), c = 854.1(2) pm, α = 69.03(2), β = 83.36(2), γ = 75.88(2).
Helmut Sigel - One of the best experts on this subject based on the ideXlab platform.
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cis diammineplatinum ii forms a macrochelate with 2 deoxycytidine 5 monophosphate dcmp 2 reactivity and acid base properties of cis 2*PT nh 3 2 dcmp
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K<0.6). The cis-2*PT(NH3)2(dCMP) complex reacts with nucleosides and nucleotides (L′) by losing its chelate structure and forming mixed ligand complexes, cis-2*PT(NH3)2(dCMP)(L′); this means that the phosphate group is released from the coordination sphere of 2*PT(II), indicating that the 2*PT(II)-O(phosphate) bond is not very strong.
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Cis -diammineplatinum(II) forms a macrochelate with 2′-deoxycytidine 5′-monophosphate (dCMP 2– )! Reactivity and acid-base properties of cis -2*PT(NH 3 ) 2 (dCMP)
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K
Ingo Rombeck - One of the best experts on this subject based on the ideXlab platform.
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cis diammineplatinum ii forms a macrochelate with 2 deoxycytidine 5 monophosphate dcmp 2 reactivity and acid base properties of cis 2*PT nh 3 2 dcmp
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K<0.6). The cis-2*PT(NH3)2(dCMP) complex reacts with nucleosides and nucleotides (L′) by losing its chelate structure and forming mixed ligand complexes, cis-2*PT(NH3)2(dCMP)(L′); this means that the phosphate group is released from the coordination sphere of 2*PT(II), indicating that the 2*PT(II)-O(phosphate) bond is not very strong.
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Cis -diammineplatinum(II) forms a macrochelate with 2′-deoxycytidine 5′-monophosphate (dCMP 2– )! Reactivity and acid-base properties of cis -2*PT(NH 3 ) 2 (dCMP)
Journal of Biological Inorganic Chemistry, 1998Co-Authors: Gerda Oswald, Ingo Rombeck, Helmut Sigel, Bin Song, Bernhard LippertAbstract:The synthesis of cis-2*PT(NH3)2(dCMP) is reported and by various physico-chemical methods it is demonstrated that it is a macrochelate in which 2*PT(II) is bound simultaneously to the N3 site of cytosine in dCMP2– and to a phosphate-oxygen atom. According to the NOESY spectra (cross-peaks between cytosine H6 and H2′ and H3′) the cytosine ring ado2*PTs an anti orientation. Highly unusual is the significant (1 ppm) downfield shift of the sugar proton H5″ in the 1H-NMR spectrum and the sensitivity of the cytosine H6 resonance on the protonation state of the phosphate group. Based on these three features a geometry for the macrochelate is proposed. The compound is a major product of the reaction of cis-[2*PT(NH3)2(H2O)2]2+ with dCMP2– at neutral pH, but it even forms at pH 5. By applying pD-dependent NMR spectroscopy (1H, 31P) and potentiometric pH titration, it is demonstrated that the 2*PT-coordinated phosphate group can be protonated (pKa/1=3.21±0.10 and 3.31±0.05, respectively), and 1H- and 31P-NMR spectra also indicate deprotonation (pKa/2=13.35±0.25) of the exocyclic amino group of the cytosine moiety. The metal ion binding affinity of cis-2*PT(NH3)2(dCMP) is very small, as shown for Cu2+ (log K