The Experts below are selected from a list of 3651 Experts worldwide ranked by ideXlab platform
Solhe F Alshahateet - One of the best experts on this subject based on the ideXlab platform.
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a facile synthesis of 3 5 dimethyl 4 Hydroxybenzaldehyde via copper mediated selective oxidation of 2 4 6 trimethylphenol
Catalysis Today, 2008Co-Authors: Zaher M A Judeh, Solhe F AlshahateetAbstract:2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-Hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl 2 in the presence of K 2 CO 3 and H 2 O 2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl 2 , K 2 CO 3 and H 2 O 2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.
Jungsang Ha - One of the best experts on this subject based on the ideXlab platform.
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4 Hydroxybenzaldehyde from gastrodia elata b1 is active in the antioxidation and gabaergic neuromodulation of the rat brain
Journal of Ethnopharmacology, 2000Co-Authors: Jeounghee Ha, Chulsoon Yong, Jungsang HaAbstract:Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4-Hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-Hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1.
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4 Hydroxybenzaldehyde from gastrodia elata b1 is active in the antioxidation and gabaergic neuromodulation of the rat brain
Journal of Ethnopharmacology, 2000Co-Authors: Jeounghee Ha, Chulsoon Yong, Jungsang HaAbstract:Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4-Hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-Hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1.
Huacan Song - One of the best experts on this subject based on the ideXlab platform.
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design synthesis and evaluation of difunctionalized 4 Hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors
ChemInform, 2011Co-Authors: Liang Yu, Wei Yi, Zhiyong Chen, Huacan SongAbstract:A series of difunctionalized 4-Hydroxybenzaldehyde derivatives (I) is designed, synthesized, and evaluated as cholinesterase (AChE, BChE) inhibitors.
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design synthesis and evaluation of difunctionalized 4 Hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors
Chemical & Pharmaceutical Bulletin, 2010Co-Authors: Liang Yu, Wei Yi, Zhiyong Chen, Huacan SongAbstract:A series of difunctionalized 4-Hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors. The results demonstrated that all the compounds had more potent AChE and BChE inhibitory activities than galanthamine-HBr, one of the best cholinesterase inhibitors known so far. The inhibition mechanism revealed that the best active compound 4e displayed a mix-type mode of AChE and BChE by its dual-site interactions with the catalytic triad active center and the peripheral anionic site (PAS) of enzyme. All these data suggested that further development of such compounds may be of interest.
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synthesis and biological evaluation of novel 4 Hydroxybenzaldehyde derivatives as tyrosinase inhibitors
European Journal of Medicinal Chemistry, 2010Co-Authors: Wei Yi, Wenlie Peng, Binhua Zhou, Huacan SongAbstract:Abstract A series of novel 4-Hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-Hydroxybenzaldehyde (IC50 = 1.22 mM). Interestingly, compound 3c bearing a dimethoxyl phosphate was found to be the most potent inhibitor with IC50 value of 0.059 mM. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 3c was a non-competitive inhibitor (KI = 0.0368 mM). In particular, compound 3c showed no side effects at dose of 1600 mg/kg in mice. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors.
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inhibitory effects of 5 benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities
European Journal of Medicinal Chemistry, 2009Co-Authors: Qin Yan, Zhiyong Chen, Rihui Cao, Huan Wen, Huacan SongAbstract:Abstract A series of novel 5-benzylidene barbiturate and thiobarbiturate derivatives were synthesized and evaluated as tyrosinase inhibitors and antibacterial agents. The results demonstrated that some compounds had more potent inhibitory activities than the parent compound 4-Hydroxybenzaldehyde (IC50 = 1.22 mM). Particularly, compounds 1a and 2a were found to be the most potent inhibitors with IC50 value of 13.98 μM and 14.49 μM, respectively. The inhibition mechanism study revealed that these compounds were irreversible inhibitors. The circular dichroism spectra indicated that these compounds induced conformational changes of mushroom tyrosinase upon binding. In addition, these compounds exhibited selectively antibacterial activity against Staphylococcus aureus. All these results suggested that further development of such compounds may be of interest.
Zaher M A Judeh - One of the best experts on this subject based on the ideXlab platform.
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a facile synthesis of 3 5 dimethyl 4 Hydroxybenzaldehyde via copper mediated selective oxidation of 2 4 6 trimethylphenol
Catalysis Today, 2008Co-Authors: Zaher M A Judeh, Solhe F AlshahateetAbstract:2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-Hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl 2 in the presence of K 2 CO 3 and H 2 O 2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl 2 , K 2 CO 3 and H 2 O 2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.
Jeounghee Ha - One of the best experts on this subject based on the ideXlab platform.
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4 Hydroxybenzaldehyde from gastrodia elata b1 is active in the antioxidation and gabaergic neuromodulation of the rat brain
Journal of Ethnopharmacology, 2000Co-Authors: Jeounghee Ha, Chulsoon Yong, Jungsang HaAbstract:Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4-Hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-Hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1.
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4 Hydroxybenzaldehyde from gastrodia elata b1 is active in the antioxidation and gabaergic neuromodulation of the rat brain
Journal of Ethnopharmacology, 2000Co-Authors: Jeounghee Ha, Chulsoon Yong, Jungsang HaAbstract:Ether fraction of G. elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4-Hydroxybenzaldehyde. It may be concluded that antioxidation and positive modulation of GABAergic neuromodulation of 4-Hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1.
