The Experts below are selected from a list of 3624 Experts worldwide ranked by ideXlab platform
Huaiqing Zhao - One of the best experts on this subject based on the ideXlab platform.
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copper silver cocatalyzed regioselective c5 h functionalization of 8 aminoquinoline amides with 1 3 dicarbonyl compounds
Synthesis, 2020Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing ZhaoAbstract:A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.
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Copper/Silver Cocatalyzed Regioselective C5–H Functionalization of 8-Aminoquinoline Amides with 1,3-Dicarbonyl Compounds
Synthesis, 2020Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing ZhaoAbstract:A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.
Duddu S Sharada - One of the best experts on this subject based on the ideXlab platform.
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a new route for the synthesis of highly substituted 4 aminoquinoline drug like molecules via aza hetero diels alder reaction
Organic and Biomolecular Chemistry, 2015Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S SharadaAbstract:We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.
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A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero–Diels–Alder reaction
Organic and Biomolecular Chemistry, 2015Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S SharadaAbstract:We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.
Fuxu Zhan - One of the best experts on this subject based on the ideXlab platform.
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copper silver cocatalyzed regioselective c5 h functionalization of 8 aminoquinoline amides with 1 3 dicarbonyl compounds
Synthesis, 2020Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing ZhaoAbstract:A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.
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Copper/Silver Cocatalyzed Regioselective C5–H Functionalization of 8-Aminoquinoline Amides with 1,3-Dicarbonyl Compounds
Synthesis, 2020Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing ZhaoAbstract:A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.
Shinde Vidyacharan - One of the best experts on this subject based on the ideXlab platform.
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a new route for the synthesis of highly substituted 4 aminoquinoline drug like molecules via aza hetero diels alder reaction
Organic and Biomolecular Chemistry, 2015Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S SharadaAbstract:We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.
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A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero–Diels–Alder reaction
Organic and Biomolecular Chemistry, 2015Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S SharadaAbstract:We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.
Yunyun Liu - One of the best experts on this subject based on the ideXlab platform.
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Copper-Catalyzed C5-H Sulfenylation of Unprotected 8-Aminoquinolines Using Sulfonyl Hydrazides.
Journal of Organic Chemistry, 2018Co-Authors: Yiming Yang, Jie-ping Wan, Yunyun LiuAbstract:The synthesis of C5-sulfenylated 8-Aminoquinolines using unprotected 8-Aminoquinolines and sulfonyl hydrazides is achieved via the catalysis of CuI. The reactions are hypothesized to proceed via the Cu(I)–Cu(II)–Cu(I) catalytic processes induced by aerobic oxidation and single-electron transfer on the Cu(II)–8-Aminoquinoline complex. This work discloses an unprecedented step-efficient method for the synthesis of C5-sulfenylated 8-Aminoquinolines bearing a useful free NH2 group.
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Copper-Catalyzed One-Pot N-Acylation and C5–H Halogenation of 8-Aminoquinolines: The Dual Role of Acyl Halides
The Journal of organic chemistry, 2018Co-Authors: Yi Dua, Yunyun Liu, Jie-ping WanAbstract:The synthesis of N-acyl-5-halo-8-Aminoquinolines has been realized by directly employing 8-Aminoquinolines and acyl halides (Cl, Br, I) with copper catalysis. The construction of the target products involves domino N-acylation and C5–H halogenations of the 8-Aminoquinoline, wherein the acyl halides act as the donors of both acyl and halide atoms, which enables the first access to the step efficient synthesis of 5-halogenated N-acyl quinlolines.
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Copper-Catalyzed C5–H Sulfenylation of Unprotected 8‑Aminoquinolines Using Sulfonyl Hydrazides
2018Co-Authors: Yiming Yang, Jie-ping Wan, Yunyun LiuAbstract:The synthesis of C5-sulfenylated 8-Aminoquinolines using unprotected 8-Aminoquinolines and sulfonyl hydrazides is achieved via the catalysis of CuI. The reactions are hypothesized to proceed via the Cu(I)–Cu(II)–Cu(I) catalytic processes induced by aerobic oxidation and single-electron transfer on the Cu(II)–8-Aminoquinoline complex. This work discloses an unprecedented step-efficient method for the synthesis of C5-sulfenylated 8-Aminoquinolines bearing a useful free NH2 group