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8-Aminoquinoline

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Huaiqing Zhao – One of the best experts on this subject based on the ideXlab platform.

  • copper silver cocatalyzed regioselective c5 h functionalization of 8 aminoquinoline amides with 1 3 dicarbonyl compounds
    Synthesis, 2020
    Co-Authors: Fuxu Zhan, Huaiqing Zhao, Wei Zhang

    Abstract:

    A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.

  • Copper/Silver Cocatalyzed Regioselective C5–H Functionalization of 8-Aminoquinoline Amides with 1,3-Dicarbonyl Compounds
    Synthesis, 2020
    Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing Zhao

    Abstract:

    A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.

Duddu S Sharada – One of the best experts on this subject based on the ideXlab platform.

  • a new route for the synthesis of highly substituted 4 aminoquinoline drug like molecules via aza hetero diels alder reaction
    Organic and Biomolecular Chemistry, 2015
    Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S Sharada

    Abstract:

    We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.

  • A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero–Diels–Alder reaction
    Organic and Biomolecular Chemistry, 2015
    Co-Authors: Shinde Vidyacharan, A Sagar, Duddu S Sharada

    Abstract:

    We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero–Diels–Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic–heterocylic (H–H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C–N, 1N–N and 1C–C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.

Fuxu Zhan – One of the best experts on this subject based on the ideXlab platform.

  • copper silver cocatalyzed regioselective c5 h functionalization of 8 aminoquinoline amides with 1 3 dicarbonyl compounds
    Synthesis, 2020
    Co-Authors: Fuxu Zhan, Huaiqing Zhao, Wei Zhang

    Abstract:

    A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.

  • Copper/Silver Cocatalyzed Regioselective C5–H Functionalization of 8-Aminoquinoline Amides with 1,3-Dicarbonyl Compounds
    Synthesis, 2020
    Co-Authors: Fuxu Zhan, Wei Zhang, Huaiqing Zhao

    Abstract:

    A copper/silver co-catalyzed cross-dehydrogenative coupling reaction is developed to achieve exclusively remote C5–H coupling of 8-Aminoquinoline amides with the methylenic sp3 C–H bond of 1,3-dicarbonyl compounds. This protocol provides a highly regioselective synthetic route for the functionalization of 8-Aminoquinoline amides at C5 under mild conditions. Preliminary experiments reveal that radicals may be involved in this catalytic transformation.