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A549 Cell

The Experts below are selected from a list of 53334 Experts worldwide ranked by ideXlab platform

Junying Miao – 1st expert on this subject based on the ideXlab platform

  • synthesis of novel substituted pyrazole 5 carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer Cells
    Bioorganic & Medicinal Chemistry, 2009
    Co-Authors: Liangwen Zheng, Baoxiang Zhao, Lingling Wu, Wenliang Dong, Junying Miao

    Abstract:

    Abstract A series of novel 3-aryl-1-(4- tert -butylbenzyl) – 1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer Cells and compound ( E )-1-(4- tert -butylbenzyl)- N ′-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1 H -pyrazole-5-carbohydrazide ( 3e ) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer Cells.

  • synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer Cells
    European Journal of Medicinal Chemistry, 2008
    Co-Authors: Baoxiang Zhao, Dongsoo Shin, Jing Zhao, Junying Miao

    Abstract:

    Abstract A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 Cells. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with Log P values in the range of 4.12–6.80 had inhibitory effects on the growth of A549 Cells, and among of them the hydrazone derived from salicylaldehyde had much more inhibitory effects.

  • synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide derivatives as potential agents against A549 lung cancer Cells
    Bioorganic & Medicinal Chemistry, 2007
    Co-Authors: Zhiwu Dong, Baoxiang Zhao, Dongsoo Shin, Xiao Ge, Ning Meng, Junying Miao

    Abstract:

    Abstract A series of novel 1-arylmethyl-3-aryl-1 H -pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 Cells and induced the Cell apoptosis. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with log  P values in the range of 3.12–4.94 had more inhibitory effects on the growth of A549 Cells.

Baoxiang Zhao – 2nd expert on this subject based on the ideXlab platform

  • synthesis of novel substituted pyrazole 5 carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer Cells
    Bioorganic & Medicinal Chemistry, 2009
    Co-Authors: Liangwen Zheng, Baoxiang Zhao, Lingling Wu, Wenliang Dong, Junying Miao

    Abstract:

    Abstract A series of novel 3-aryl-1-(4- tert -butylbenzyl) – 1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer Cells and compound ( E )-1-(4- tert -butylbenzyl)- N ′-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1 H -pyrazole-5-carbohydrazide ( 3e ) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer Cells.

  • synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer Cells
    European Journal of Medicinal Chemistry, 2008
    Co-Authors: Baoxiang Zhao, Dongsoo Shin, Jing Zhao, Junying Miao

    Abstract:

    Abstract A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 Cells. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with Log P values in the range of 4.12–6.80 had inhibitory effects on the growth of A549 Cells, and among of them the hydrazone derived from salicylaldehyde had much more inhibitory effects.

  • synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide derivatives as potential agents against A549 lung cancer Cells
    Bioorganic & Medicinal Chemistry, 2007
    Co-Authors: Zhiwu Dong, Baoxiang Zhao, Dongsoo Shin, Xiao Ge, Ning Meng, Junying Miao

    Abstract:

    Abstract A series of novel 1-arylmethyl-3-aryl-1 H -pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 Cells and induced the Cell apoptosis. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with log  P values in the range of 3.12–4.94 had more inhibitory effects on the growth of A549 Cells.

Zhengtang Chen – 3rd expert on this subject based on the ideXlab platform

  • knockdown of snail a novel zinc finger transcription factor via rna interference increases A549 Cell sensitivity to cisplatin via jnk mitochondrial pathway
    Lung Cancer, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Xujun Ao, Zhengtang Chen

    Abstract:

    Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer Cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer Cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 Cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 Cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.

  • short interfering rna directed against twist a novel zinc finger transcription factor increases A549 Cell sensitivity to cisplatin via mapk mitochondrial pathway
    Biochemical and Biophysical Research Communications, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Zhengtang Chen

    Abstract:

    Abstract Previous reports have implicated epithelial–mesenchymal transition (EMT) as a major cause of cancer. TWIST, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether TWIST suppression could increase chemosensitivity of cancer Cells to chemotherapeutic agent remains unclear. In the present study, we utilized RNA interference to knockdown TWIST expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible MAPKs and mitochondrial pathways. The data showed that TWIST depletion significantly sensitized A549 Cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 Cell chemoresistance to cisplatin and raising the possibility of TWIST depletion as a promising approach to lung cancer therapy.