The Experts below are selected from a list of 53334 Experts worldwide ranked by ideXlab platform
Junying Miao - One of the best experts on this subject based on the ideXlab platform.
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synthesis of novel substituted pyrazole 5 carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer Cells
Bioorganic & Medicinal Chemistry, 2009Co-Authors: Liangwen Zheng, Baoxiang Zhao, Lingling Wu, Wenliang Dong, Junying MiaoAbstract:Abstract A series of novel 3-aryl-1-(4- tert -butylbenzyl) - 1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer Cells and compound ( E )-1-(4- tert -butylbenzyl)- N ′-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1 H -pyrazole-5-carbohydrazide ( 3e ) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer Cells.
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synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer Cells
European Journal of Medicinal Chemistry, 2008Co-Authors: Baoxiang Zhao, Dongsoo Shin, Jing Zhao, Junying MiaoAbstract:Abstract A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 Cells. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with Log P values in the range of 4.12–6.80 had inhibitory effects on the growth of A549 Cells, and among of them the hydrazone derived from salicylaldehyde had much more inhibitory effects.
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synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide derivatives as potential agents against A549 lung cancer Cells
Bioorganic & Medicinal Chemistry, 2007Co-Authors: Zhiwu Dong, Baoxiang Zhao, Dongsoo Shin, Xiao Ge, Ning Meng, Junying MiaoAbstract:Abstract A series of novel 1-arylmethyl-3-aryl-1 H -pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 Cells and induced the Cell apoptosis. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with log P values in the range of 3.12–4.94 had more inhibitory effects on the growth of A549 Cells.
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design synthesis and preliminary biological evaluation of 2 3 dihydro 3 hydroxymethyl 1 4 benzoxazine derivatives
Bioorganic & Medicinal Chemistry Letters, 2006Co-Authors: Peifu Jiao, Baoxiang Zhao, Weiwei Wang, Qiuxia He, Dongsoo Shin, Junying MiaoAbstract:Abstract We synthesized a series of novel small molecules, 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives, by tandem reduction-oxirane opening of 2-nitroaroxymethyloxiranes in moderate or exCellent yields. We investigated the effects of all of the compounds on HUVEC apoptosis and A549 Cell growth. The results showed that 6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine was the most effective small molecule in promoting HUVEC apoptosis and inhibiting A549 Cell proliferation, but 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine could remarkably inhibit HUVEC apoptosis and might induce the formation of microvessel.
Baoxiang Zhao - One of the best experts on this subject based on the ideXlab platform.
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synthesis of novel substituted pyrazole 5 carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer Cells
Bioorganic & Medicinal Chemistry, 2009Co-Authors: Liangwen Zheng, Baoxiang Zhao, Lingling Wu, Wenliang Dong, Junying MiaoAbstract:Abstract A series of novel 3-aryl-1-(4- tert -butylbenzyl) - 1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer Cells and compound ( E )-1-(4- tert -butylbenzyl)- N ′-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1 H -pyrazole-5-carbohydrazide ( 3e ) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer Cells.
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synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer Cells
European Journal of Medicinal Chemistry, 2008Co-Authors: Baoxiang Zhao, Dongsoo Shin, Jing Zhao, Junying MiaoAbstract:Abstract A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 Cells. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with Log P values in the range of 4.12–6.80 had inhibitory effects on the growth of A549 Cells, and among of them the hydrazone derived from salicylaldehyde had much more inhibitory effects.
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synthesis and structure activity relationships of novel 1 arylmethyl 3 aryl 1h pyrazole 5 carbohydrazide derivatives as potential agents against A549 lung cancer Cells
Bioorganic & Medicinal Chemistry, 2007Co-Authors: Zhiwu Dong, Baoxiang Zhao, Dongsoo Shin, Xiao Ge, Ning Meng, Junying MiaoAbstract:Abstract A series of novel 1-arylmethyl-3-aryl-1 H -pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 Cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 Cells and induced the Cell apoptosis. The study on structure–activity relationships and prediction of lipophilicities of compounds showed that compounds with log P values in the range of 3.12–4.94 had more inhibitory effects on the growth of A549 Cells.
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design synthesis and preliminary biological evaluation of 2 3 dihydro 3 hydroxymethyl 1 4 benzoxazine derivatives
Bioorganic & Medicinal Chemistry Letters, 2006Co-Authors: Peifu Jiao, Baoxiang Zhao, Weiwei Wang, Qiuxia He, Dongsoo Shin, Junying MiaoAbstract:Abstract We synthesized a series of novel small molecules, 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives, by tandem reduction-oxirane opening of 2-nitroaroxymethyloxiranes in moderate or exCellent yields. We investigated the effects of all of the compounds on HUVEC apoptosis and A549 Cell growth. The results showed that 6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine was the most effective small molecule in promoting HUVEC apoptosis and inhibiting A549 Cell proliferation, but 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine could remarkably inhibit HUVEC apoptosis and might induce the formation of microvessel.
Zhengtang Chen - One of the best experts on this subject based on the ideXlab platform.
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knockdown of snail a novel zinc finger transcription factor via rna interference increases A549 Cell sensitivity to cisplatin via jnk mitochondrial pathway
Lung Cancer, 2008Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Xujun Ao, Zhengtang ChenAbstract:Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer Cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer Cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 Cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 Cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.
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short interfering rna directed against twist a novel zinc finger transcription factor increases A549 Cell sensitivity to cisplatin via mapk mitochondrial pathway
Biochemical and Biophysical Research Communications, 2008Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Zhengtang ChenAbstract:Abstract Previous reports have implicated epithelial–mesenchymal transition (EMT) as a major cause of cancer. TWIST, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether TWIST suppression could increase chemosensitivity of cancer Cells to chemotherapeutic agent remains unclear. In the present study, we utilized RNA interference to knockdown TWIST expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible MAPKs and mitochondrial pathways. The data showed that TWIST depletion significantly sensitized A549 Cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 Cell chemoresistance to cisplatin and raising the possibility of TWIST depletion as a promising approach to lung cancer therapy.
Wenlei Zhuo - One of the best experts on this subject based on the ideXlab platform.
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knockdown of snail a novel zinc finger transcription factor via rna interference increases A549 Cell sensitivity to cisplatin via jnk mitochondrial pathway
Lung Cancer, 2008Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Xujun Ao, Zhengtang ChenAbstract:Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer Cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer Cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 Cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 Cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.
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short interfering rna directed against twist a novel zinc finger transcription factor increases A549 Cell sensitivity to cisplatin via mapk mitochondrial pathway
Biochemical and Biophysical Research Communications, 2008Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Zhengtang ChenAbstract:Abstract Previous reports have implicated epithelial–mesenchymal transition (EMT) as a major cause of cancer. TWIST, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether TWIST suppression could increase chemosensitivity of cancer Cells to chemotherapeutic agent remains unclear. In the present study, we utilized RNA interference to knockdown TWIST expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible MAPKs and mitochondrial pathways. The data showed that TWIST depletion significantly sensitized A549 Cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 Cell chemoresistance to cisplatin and raising the possibility of TWIST depletion as a promising approach to lung cancer therapy.
Boyang Yu - One of the best experts on this subject based on the ideXlab platform.
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novel steroidal saponins with cytotoxic activities from the roots of ophiopogon japonicus l f ker gawl
RSC Advances, 2018Co-Authors: Yan Wu, Suxia Bi, Jin Qi, Zhen Huang, Boyang YuAbstract:Six new steroidal saponins (1–6) and one known steroidal saponin (7) were obtained from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The in vitro cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 Cell lines were also investigated.
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novel cytotoxic steroidal saponins from the roots of liriope muscari decne l h bailey
RSC Advances, 2017Co-Authors: Yan Wu, Suxia Bi, Xianmin Wang, Ruijing Wang, Ruiming Li, Boyang Yu, Wen Zhang, Jin QiAbstract:Ten new steroidal saponins (1–10) and three known steroidal saponins (11–13) were isolated from a 70% EtOH extract of the roots of Liriope muscari (Decne.) L. H. Bailey. Their structures were determined by analyses of infrared, nuclear magnetic resonance and mass spectroscopic data. These compounds exhibited different levels of cytotoxic activity against MDA-MB-435, 95D, HepG2, HeLa, MCF-7 and A549 Cell lines in an in vitro bioassay. The structure–activity relationship of these related compounds was also investigated.
