A549 Cell

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Junying Miao - One of the best experts on this subject based on the ideXlab platform.

Baoxiang Zhao - One of the best experts on this subject based on the ideXlab platform.

Zhengtang Chen - One of the best experts on this subject based on the ideXlab platform.

  • knockdown of snail a novel zinc finger transcription factor via rna interference increases A549 Cell sensitivity to cisplatin via jnk mitochondrial pathway
    Lung Cancer, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Xujun Ao, Zhengtang Chen
    Abstract:

    Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer Cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer Cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 Cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 Cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.

  • short interfering rna directed against twist a novel zinc finger transcription factor increases A549 Cell sensitivity to cisplatin via mapk mitochondrial pathway
    Biochemical and Biophysical Research Communications, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Zhengtang Chen
    Abstract:

    Abstract Previous reports have implicated epithelial–mesenchymal transition (EMT) as a major cause of cancer. TWIST, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether TWIST suppression could increase chemosensitivity of cancer Cells to chemotherapeutic agent remains unclear. In the present study, we utilized RNA interference to knockdown TWIST expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible MAPKs and mitochondrial pathways. The data showed that TWIST depletion significantly sensitized A549 Cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 Cell chemoresistance to cisplatin and raising the possibility of TWIST depletion as a promising approach to lung cancer therapy.

Wenlei Zhuo - One of the best experts on this subject based on the ideXlab platform.

  • knockdown of snail a novel zinc finger transcription factor via rna interference increases A549 Cell sensitivity to cisplatin via jnk mitochondrial pathway
    Lung Cancer, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Xujun Ao, Zhengtang Chen
    Abstract:

    Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer Cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer Cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 Cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 Cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.

  • short interfering rna directed against twist a novel zinc finger transcription factor increases A549 Cell sensitivity to cisplatin via mapk mitochondrial pathway
    Biochemical and Biophysical Research Communications, 2008
    Co-Authors: Wenlei Zhuo, Yan Wang, Xianlu Zhuo, Yunsong Zhang, Zhengtang Chen
    Abstract:

    Abstract Previous reports have implicated epithelial–mesenchymal transition (EMT) as a major cause of cancer. TWIST, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether TWIST suppression could increase chemosensitivity of cancer Cells to chemotherapeutic agent remains unclear. In the present study, we utilized RNA interference to knockdown TWIST expression in A549 Cells and further assessed the Cell viability and apoptosis as well as possible MAPKs and mitochondrial pathways. The data showed that TWIST depletion significantly sensitized A549 Cells to cisplatin by inducing activation of JNK/mitochondrial pathway but not ERK and p-38 pathways, suggesting critical roles of TWIST in A549 Cell chemoresistance to cisplatin and raising the possibility of TWIST depletion as a promising approach to lung cancer therapy.

Boyang Yu - One of the best experts on this subject based on the ideXlab platform.