The Experts below are selected from a list of 15078 Experts worldwide ranked by ideXlab platform
Guy E. Boeckxstaens - One of the best experts on this subject based on the ideXlab platform.
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Postoperative Ileus: Pathophysiology, Current Therapeutic Approaches.
Handbook of experimental pharmacology, 2016Co-Authors: Nathalie Stakenborg, Pedro J. Gomez-pinilla, Guy E. BoeckxstaensAbstract:Postoperative ileus, which develops after each Abdominal Surgical Procedure, is an iatrogenic disorder characterized by a transient inhibition of gastrointestinal motility. Its pathophysiology is complex involving pharmacological (opioids, anesthetics), neural, and immune-mediated mechanisms. The early neural phase, triggered by activation of afferent nerves during the Surgical Procedure, is short lasting compared to the later inflammatory phase. The latter starts after 3–6 h and lasts several days, making it a more interesting target for treatment. Insight into the triggers and immune cells involved is of great importance for the development of new therapeutic strategies. In this chapter, the pathogenesis and the current therapeutic approaches to treat postoperative ileus are discussed.
G. B. Melis - One of the best experts on this subject based on the ideXlab platform.
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postoperative pain and postoperative recovery following respective laparoscopy no relation to the intra Abdominal Surgical Procedure
Gynaecological Endoscopy, 1996Co-Authors: Valerio Mais, Silvia Ajossa, Stefano Guerriero, R Peiretti, F. Serri, G. B. MelisAbstract:Objective To investigate whether different resective Procedures might be related to different intensities of postoperative pain and different subjective recovery times following laparoscopic surgery Interventions A total of 60 patients underwent laparoscopic myomectomy, 60 patients underwent laparascopic excision of endometriomas, and 60 patients underwent laparoscopic enucleation of non-endometriotic adnexal cysts. Measures The intensity of postoperative pain was assessed by completion of a visual analogue scale on the day of surgery and 1, 2, and 3 days postoperatively, and the results of the three groups were compared. We also compared the proportions of patients who were analgesic free on day 2, discharged from hospital within 3 days, and feeling fully recuperated on day 15. Results No differences were found among the three groups of patients. Conclusions Both the intensity of postoperative pain and the length of convalescence following resective laparoscopy do not seem to depend on the intra-Abdominal Surgical Procedure.
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Postoperative pain and postoperative recovery following respective laparoscopy: no relation to the intra‐Abdominal Surgical Procedure
Gynaecological Endoscopy, 1996Co-Authors: Valerio Mais, Silvia Ajossa, Stefano Guerriero, R Peiretti, F. Serri, G. B. MelisAbstract:Objective To investigate whether different resective Procedures might be related to different intensities of postoperative pain and different subjective recovery times following laparoscopic surgery Interventions A total of 60 patients underwent laparoscopic myomectomy, 60 patients underwent laparascopic excision of endometriomas, and 60 patients underwent laparoscopic enucleation of non-endometriotic adnexal cysts. Measures The intensity of postoperative pain was assessed by completion of a visual analogue scale on the day of surgery and 1, 2, and 3 days postoperatively, and the results of the three groups were compared. We also compared the proportions of patients who were analgesic free on day 2, discharged from hospital within 3 days, and feeling fully recuperated on day 15. Results No differences were found among the three groups of patients. Conclusions Both the intensity of postoperative pain and the length of convalescence following resective laparoscopy do not seem to depend on the intra-Abdominal Surgical Procedure.
David S Baldwin - One of the best experts on this subject based on the ideXlab platform.
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once daily insulin glargine versus 6 hour sliding scale regular insulin for control of hyperglycemia after a bariatric Surgical Procedure a randomized clinical trial
Endocrine Practice, 2007Co-Authors: Swati Datta, Arshia Qaadir, Griselda Villanueva, David S BaldwinAbstract:OBJECTIVE: To determine whether once-daily insulin glargine could provide better glycemic control after an Abdominal Surgical Procedure than the traditional use of sliding scale regular insulin (SSRI). METHODS: Because 20% to 30% of patients undergoing gastric bypass have a history of overt diabetes and another 5% to 10% are estimated to have impaired glucose tolerance, we chose to study these patients. We treated 81 patients with postoperative blood glucose levels of more than 144 mg/dL after a Roux-en-Y gastric bypass Surgical Procedure. They were randomized to receive either SSRI or insulin glargine either directly or after initial intravenous insulin infusion in the intensive care unit (ICU). RESULTS: Overall, the mean blood glucose level after SSRI therapy was 154 +/- 33 mg/dL, and the mean blood glucose value after insulin glargine treatment was 134 +/- 30 mg/dL (P<0.01). The mean blood glucose level for patients first treated with intravenous insulin infusion in the ICU was 125 mg/dL, in comparison with 145 mg/dL in the non-ICU patients whose treatment began directly with 0.3 U/kg of insulin glargine. Of 926 blood glucose measurements, only 3 were less than 60 mg/dL. CONCLUSION: In this study, control of postoperative hyperglycemia was significantly better with use of insulin glargine in comparison with SSRI therapy, and hypoglycemia was very infrequent.
Nathalie Stakenborg - One of the best experts on this subject based on the ideXlab platform.
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Postoperative Ileus: Pathophysiology, Current Therapeutic Approaches.
Handbook of experimental pharmacology, 2016Co-Authors: Nathalie Stakenborg, Pedro J. Gomez-pinilla, Guy E. BoeckxstaensAbstract:Postoperative ileus, which develops after each Abdominal Surgical Procedure, is an iatrogenic disorder characterized by a transient inhibition of gastrointestinal motility. Its pathophysiology is complex involving pharmacological (opioids, anesthetics), neural, and immune-mediated mechanisms. The early neural phase, triggered by activation of afferent nerves during the Surgical Procedure, is short lasting compared to the later inflammatory phase. The latter starts after 3–6 h and lasts several days, making it a more interesting target for treatment. Insight into the triggers and immune cells involved is of great importance for the development of new therapeutic strategies. In this chapter, the pathogenesis and the current therapeutic approaches to treat postoperative ileus are discussed.
Fabian Grass - One of the best experts on this subject based on the ideXlab platform.
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risk factors for 90 day readmission and return to the operating room following Abdominal operations for crohn s disease
Surgery, 2019Co-Authors: Fabian Grass, James Ansell, Molly M Petersen, Kellie L Mathis, Amy L LightnerAbstract:Abstract Background This study aimed to determine timing and risk factors for 30- and 90-day unplanned hospital readmissions and return to the operating room. Methods Retrospective case series, including consecutive adult patients with Crohn’s disease, undergoing a major Abdominal Surgical Procedure during a 3.5-year inclusion period was performed. The primary outcomes were 0- to 30-day and 30- to 90-day readmission and return to the operating room rates. Univariate and multivariable risk factors for both outcomes at 30 and 90 days were assessed through Cox regression analysis. Results Of 680 included patients with Crohn’s disease, 89 (13.1%) were readmitted within 30 days, 55 (8.1%) within 30–90 days, and 11 (1.6%) in both follow-up periods for a combined 90-day readmission rate of 24.4% (n = 166). Multivariable risk factors for 30-day readmissions were type of Procedure performed, corticosteroid use (hazard ratio [HR] 1.71, P = .01), younger age (HR 0.98 per year, P = .01), and prolonged disease duration (HR 1.03 per year, P = .03). No significant risk factors identified for 30- to 90-day readmissions. By 90 days, 76 patients (11.2%) had a return to the operating room (of which 8.8% was within 30 days). Risk factors for 30-day return to the operating room included tobacco use (HR 1.86, P = .04), diabetes (HR 3.30, P = .01), corticosteroid use (HR 3.51, P Conclusion Type of surgery, corticosteroid use, younger age, and prolonged disease duration were associated with 30-day hospital readmission, and tobacco use, diabetes, corticosteroid use, and preoperative immunomodulator therapy were risk factors for 30-day return to the operating room. Postoperative biologic therapy did not increase hospital readmission or return to operating room rates within 90 days of surgery.
