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Guy E. Boeckxstaens – One of the best experts on this subject based on the ideXlab platform.

  • Postoperative Ileus: Pathophysiology, Current Therapeutic Approaches.
    Handbook of experimental pharmacology, 2016
    Co-Authors: Nathalie Stakenborg, Pedro J. Gomez-pinilla, Guy E. Boeckxstaens

    Abstract:

    Postoperative ileus, which develops after each Abdominal Surgical Procedure, is an iatrogenic disorder characterized by a transient inhibition of gastrointestinal motility. Its pathophysiology is complex involving pharmacological (opioids, anesthetics), neural, and immune-mediated mechanisms. The early neural phase, triggered by activation of afferent nerves during the Surgical Procedure, is short lasting compared to the later inflammatory phase. The latter starts after 3–6 h and lasts several days, making it a more interesting target for treatment. Insight into the triggers and immune cells involved is of great importance for the development of new therapeutic strategies. In this chapter, the pathogenesis and the current therapeutic approaches to treat postoperative ileus are discussed.

G. B. Melis – One of the best experts on this subject based on the ideXlab platform.

  • postoperative pain and postoperative recovery following respective laparoscopy no relation to the intra Abdominal Surgical Procedure
    Gynaecological Endoscopy, 1996
    Co-Authors: Valerio Mais, Silvia Ajossa, Stefano Guerriero, R Peiretti, F. Serri, G. B. Melis

    Abstract:

    Objective To investigate whether different resective Procedures might be related to different intensities of postoperative pain and different subjective recovery times following laparoscopic surgery

    Interventions A total of 60 patients underwent laparoscopic myomectomy, 60 patients underwent laparascopic excision of endometriomas, and 60 patients underwent laparoscopic enucleation of non-endometriotic adnexal cysts.

    Measures The intensity of postoperative pain was assessed by completion of a visual analogue scale on the day of surgery and 1, 2, and 3 days postoperatively, and the results of the three groups were compared. We also compared the proportions of patients who were analgesic free on day 2, discharged from hospital within 3 days, and feeling fully recuperated on day 15.

    Results No differences were found among the three groups of patients.

    Conclusions Both the intensity of postoperative pain and the length of convalescence following resective laparoscopy do not seem to depend on the intra-Abdominal Surgical Procedure.

  • Postoperative pain and postoperative recovery following respective laparoscopy: no relation to the intra‐Abdominal Surgical Procedure
    Gynaecological Endoscopy, 1996
    Co-Authors: Valerio Mais, Silvia Ajossa, Stefano Guerriero, R Peiretti, F. Serri, G. B. Melis

    Abstract:

    Objective To investigate whether different resective Procedures might be related to different intensities of postoperative pain and different subjective recovery times following laparoscopic surgery

    Interventions A total of 60 patients underwent laparoscopic myomectomy, 60 patients underwent laparascopic excision of endometriomas, and 60 patients underwent laparoscopic enucleation of non-endometriotic adnexal cysts.

    Measures The intensity of postoperative pain was assessed by completion of a visual analogue scale on the day of surgery and 1, 2, and 3 days postoperatively, and the results of the three groups were compared. We also compared the proportions of patients who were analgesic free on day 2, discharged from hospital within 3 days, and feeling fully recuperated on day 15.

    Results No differences were found among the three groups of patients.

    Conclusions Both the intensity of postoperative pain and the length of convalescence following resective laparoscopy do not seem to depend on the intra-Abdominal Surgical Procedure.

David S Baldwin – One of the best experts on this subject based on the ideXlab platform.

  • once daily insulin glargine versus 6 hour sliding scale regular insulin for control of hyperglycemia after a bariatric Surgical Procedure a randomized clinical trial
    Endocrine Practice, 2007
    Co-Authors: Swati Datta, Arshia Qaadir, Griselda Villanueva, David S Baldwin

    Abstract:

    OBJECTIVE: To determine whether once-daily insulin glargine could provide better glycemic control after an Abdominal Surgical Procedure than the traditional use of sliding scale regular insulin (SSRI). METHODS: Because 20% to 30% of patients undergoing gastric bypass have a history of overt diabetes and another 5% to 10% are estimated to have impaired glucose tolerance, we chose to study these patients. We treated 81 patients with postoperative blood glucose levels of more than 144 mg/dL after a Roux-en-Y gastric bypass Surgical Procedure. They were randomized to receive either SSRI or insulin glargine either directly or after initial intravenous insulin infusion in the intensive care unit (ICU). RESULTS: Overall, the mean blood glucose level after SSRI therapy was 154 +/- 33 mg/dL, and the mean blood glucose value after insulin glargine treatment was 134 +/- 30 mg/dL (P<0.01). The mean blood glucose level for patients first treated with intravenous insulin infusion in the ICU was 125 mg/dL, in comparison with 145 mg/dL in the non-ICU patients whose treatment began directly with 0.3 U/kg of insulin glargine. Of 926 blood glucose measurements, only 3 were less than 60 mg/dL. CONCLUSION: In this study, control of postoperative hyperglycemia was significantly better with use of insulin glargine in comparison with SSRI therapy, and hypoglycemia was very infrequent.