Aborigine

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Kuoliang Yang - One of the best experts on this subject based on the ideXlab platform.

  • distributions of human leukocyte antigen a b and drb1 alleles and haplotypes based on 46 915 taiwanese donors
    Human Immunology, 2010
    Co-Authors: Mengjiun Lai, Shuhui Wen, Yahui Lin, M H Shyr, P Y Lin, Kuoliang Yang
    Abstract:

    Human leukocyte antigen (HLA)-A, -B, and -DRB1 alleles were typed in 46,915 healthy Taiwanese volunteers recruited for Tzu Chi Taiwan Marrow Donor Registry (TCTMDR). The volunteers were separated into Taiwanese and Taiwanese Aborigines. In this study, a total of 51 A, 121 B, and 53 DRB1 alleles were found in the Taiwanese group, and 17 A, 32 B, and 23 DRB1 alleles were identified in the Taiwanese Aborigines. Some commonly shared alleles appeared more frequently in one group than in the other. The two haplotypes, among the 20 most frequently observed haplotypes in each group, shared in common by both groups were A*3303-B*5801-DRB1*0301 and A*0207-B*4601-DRB1* 0901. However, both haplotype frequencies in each group were extremely different, indicating the existence of genetic diversity between the two groups. In addition, principal component analysis and clustering results based on high-resolution HLA-A, -B, and -DRB1 alleles indicated that the Taiwanese group was closest to Southern Chinese and reiterated HLA diversity between the Taiwanese and the Taiwanese Aborigines. We believe that our findings in this study may provide useful information in search for HLA-matched donors for patients.

P J Robertsthomson - One of the best experts on this subject based on the ideXlab platform.

  • rheumatic disease and the australian Aborigine
    Annals of the Rheumatic Diseases, 1999
    Co-Authors: Rachel A Robertsthomson, P J Robertsthomson
    Abstract:

    OBJECTIVE—To document the frequency and disease phenotype of various rheumatic diseases in the Australian Aborigine. METHODS—A comprehensive review was performed of the archaeological, ethnohistorical, and contemporary literature relating to rheumatic diseases in these indigenous people. RESULTS—No evidence was found to suggest that rheumatoid arthritis (RA), ankylosing spondylitis (AS), or gout occurred in Aborigines before or during the early stages of white settlement of Australia. Part of the explanation for the absence of these disorders in this indigenous group may relate to the scarcity of predisposing genetic elements, for example, shared rheumatoid epitope for RA, B27 antigen for AS. In contrast, osteoarthritis appeared to be common particularly involving the temporomandibular joint, right elbow and knees and, most probably, was related to excessive joint loading in their hunter gatherer lifestyle. Since white settlement, high frequency rates for rheumatic fever, systemic lupus erythematosus, and pyogenic arthritis have been observed and there are now scanty reports of the emergence of RA and gout in these original Australians. CONCLUSION—The occurrence and phenotype of various rheumatic disorders in Australian Aborigines is distinctive but with recent changes in diet, lifestyle, and continuing genetic admixture may be undergoing change. An examination of rheumatic diseases in Australian Aborigines and its changing phenotype may lead to a greater understanding of the aetiopathogenesis of these disorders.

Rachel A Robertsthomson - One of the best experts on this subject based on the ideXlab platform.

  • rheumatic disease and the australian Aborigine
    Annals of the Rheumatic Diseases, 1999
    Co-Authors: Rachel A Robertsthomson, P J Robertsthomson
    Abstract:

    OBJECTIVE—To document the frequency and disease phenotype of various rheumatic diseases in the Australian Aborigine. METHODS—A comprehensive review was performed of the archaeological, ethnohistorical, and contemporary literature relating to rheumatic diseases in these indigenous people. RESULTS—No evidence was found to suggest that rheumatoid arthritis (RA), ankylosing spondylitis (AS), or gout occurred in Aborigines before or during the early stages of white settlement of Australia. Part of the explanation for the absence of these disorders in this indigenous group may relate to the scarcity of predisposing genetic elements, for example, shared rheumatoid epitope for RA, B27 antigen for AS. In contrast, osteoarthritis appeared to be common particularly involving the temporomandibular joint, right elbow and knees and, most probably, was related to excessive joint loading in their hunter gatherer lifestyle. Since white settlement, high frequency rates for rheumatic fever, systemic lupus erythematosus, and pyogenic arthritis have been observed and there are now scanty reports of the emergence of RA and gout in these original Australians. CONCLUSION—The occurrence and phenotype of various rheumatic disorders in Australian Aborigines is distinctive but with recent changes in diet, lifestyle, and continuing genetic admixture may be undergoing change. An examination of rheumatic diseases in Australian Aborigines and its changing phenotype may lead to a greater understanding of the aetiopathogenesis of these disorders.

H. Dunckley - One of the best experts on this subject based on the ideXlab platform.

  • a novel drb1 allele drb1 0815 defined in an australian Aborigine
    Tissue Antigens, 1997
    Co-Authors: J Trejaut, W D Greville, N Duncan, H. Dunckley
    Abstract:

    The nucleotide sequence reported in this paper has been submitted to GenBank and assigned the accession number U63802. The name DRB1*0815 was officially assigned by the WHO Nomenclature Committee in July 1996. This follows the agreed policy that, subject to the conditions stated in the most recent nomenclature report (10), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO nomenclature report. The sequence known previously as DRB1*08Taree will now be known as DRB1*0815.

J Trejaut - One of the best experts on this subject based on the ideXlab platform.

  • philippine mitochondrial dna diversity a populated viaduct between taiwan and indonesia
    Molecular Biology and Evolution, 2010
    Co-Authors: Kristina A Tabbada, J Trejaut, Yaoming Chen, Marta Mirazonlahr, Toomas Kivisild, Maria Corazon A De Ungria
    Abstract:

    : Relatively little is known about the genetic diversity of the Philippine population, and this is an important gap in our understanding of Southeast Asian and Oceanic prehistory. Here we describe mitochondrial DNA (mtDNA) variation in 423 Philippine samples and analyze them in the context of the genetic diversity of other Southeast Asian populations. The majority of Philippine mtDNA types are shared with Taiwanese aboriginal groups and belong to haplogroups of postglacial and pre-Neolithic origin that have previously been identified in East Asian and Island Southeast Asian populations. Analysis of hypervariable segment I sequence variation within individual mtDNA haplogroups indicates a general decrease in the diversity of the most frequent types (B4a1a, E1a1a, and M7c3c) from the Taiwanese Aborigines to the Philippines and Sulawesi, although calculated standard error measures overlap for these populations. This finding, together with the geographical distribution of ancestral and derived haplotypes of the B4a1a subclade including the Polynesian Motif, is consistent with southward dispersal of these lineages "Out of Taiwan" via the Philippines to Near Oceania and Polynesia. In addition to the mtDNA components shared with Taiwanese Aborigines, complete sequence analyses revealed a minority of lineages in the Philippines that share their origins--possibly dating back to the Paleolithic--with haplogroups from Indonesia and New Guinea. Other rare lineages in the Philippines have no closely related types yet identified elsewhere.

  • a novel drb1 allele drb1 0815 defined in an australian Aborigine
    Tissue Antigens, 1997
    Co-Authors: J Trejaut, W D Greville, N Duncan, H. Dunckley
    Abstract:

    The nucleotide sequence reported in this paper has been submitted to GenBank and assigned the accession number U63802. The name DRB1*0815 was officially assigned by the WHO Nomenclature Committee in July 1996. This follows the agreed policy that, subject to the conditions stated in the most recent nomenclature report (10), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO nomenclature report. The sequence known previously as DRB1*08Taree will now be known as DRB1*0815.