The Experts below are selected from a list of 2538 Experts worldwide ranked by ideXlab platform
Hideo Shimamura - One of the best experts on this subject based on the ideXlab platform.
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variability in Absorption Lag Time of pyridoxal phosphate under fasting and pre and post meal conditions
Biopharmaceutics & Drug Disposition, 1994Co-Authors: Harumi Takahashi, Hiroyasu Ogata, Naomi Nagai, Keiko Sugito, Hideo ShimamuraAbstract:Inter-individual variations in the Absorption Lag Time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The Absorption Lag Time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger Lag Times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The Lag Time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable Absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
Harumi Takahashi - One of the best experts on this subject based on the ideXlab platform.
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variability in Absorption Lag Time of pyridoxal phosphate under fasting and pre and post meal conditions
Biopharmaceutics & Drug Disposition, 1994Co-Authors: Harumi Takahashi, Hiroyasu Ogata, Naomi Nagai, Keiko Sugito, Hideo ShimamuraAbstract:Inter-individual variations in the Absorption Lag Time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The Absorption Lag Time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger Lag Times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The Lag Time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable Absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
Keiko Sugito - One of the best experts on this subject based on the ideXlab platform.
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variability in Absorption Lag Time of pyridoxal phosphate under fasting and pre and post meal conditions
Biopharmaceutics & Drug Disposition, 1994Co-Authors: Harumi Takahashi, Hiroyasu Ogata, Naomi Nagai, Keiko Sugito, Hideo ShimamuraAbstract:Inter-individual variations in the Absorption Lag Time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The Absorption Lag Time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger Lag Times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The Lag Time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable Absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
Naomi Nagai - One of the best experts on this subject based on the ideXlab platform.
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variability in Absorption Lag Time of pyridoxal phosphate under fasting and pre and post meal conditions
Biopharmaceutics & Drug Disposition, 1994Co-Authors: Harumi Takahashi, Hiroyasu Ogata, Naomi Nagai, Keiko Sugito, Hideo ShimamuraAbstract:Inter-individual variations in the Absorption Lag Time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The Absorption Lag Time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger Lag Times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The Lag Time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable Absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
Hiroyasu Ogata - One of the best experts on this subject based on the ideXlab platform.
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variability in Absorption Lag Time of pyridoxal phosphate under fasting and pre and post meal conditions
Biopharmaceutics & Drug Disposition, 1994Co-Authors: Harumi Takahashi, Hiroyasu Ogata, Naomi Nagai, Keiko Sugito, Hideo ShimamuraAbstract:Inter-individual variations in the Absorption Lag Time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The Absorption Lag Time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger Lag Times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The Lag Time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable Absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
