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Absorption Pharmacokinetics

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L. I. Cortínez – One of the best experts on this subject based on the ideXlab platform.

  • Levobupivacaine Absorption Pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: P. Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Purpose Cases of local anaeanaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Methods Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. Results A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  

  • levobupivacaine Absorption Pharmacokinetics with and without epinephrine during tap block analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: Pablo A Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Cases of local anaeanaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  1.5 mg kg−1 are required. Recommendations regarding the maximum allowable doses of local anaesthetics should consider population analysis to determine safer dosage ranges.

G. C. Echevarría – One of the best experts on this subject based on the ideXlab platform.

  • Levobupivacaine Absorption Pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: P. Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Purpose Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Methods Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. Results A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  

  • levobupivacaine Absorption Pharmacokinetics with and without epinephrine during tap block analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: Pablo A Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  1.5 mg kg−1 are required. Recommendations regarding the maximum allowable doses of local anaesthetics should consider population analysis to determine safer dosage ranges.

A. Araneda – One of the best experts on this subject based on the ideXlab platform.

  • Levobupivacaine Absorption Pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: P. Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Purpose Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Methods Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. Results A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  

  • levobupivacaine Absorption Pharmacokinetics with and without epinephrine during tap block analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: Pablo A Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  1.5 mg kg−1 are required. Recommendations regarding the maximum allowable doses of local anaesthetics should consider population analysis to determine safer dosage ranges.

Fernando R. Altermatt – One of the best experts on this subject based on the ideXlab platform.

  • Levobupivacaine Absorption Pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: P. Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Purpose Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Methods Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. Results A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  

  • levobupivacaine Absorption Pharmacokinetics with and without epinephrine during tap block analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: Pablo A Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  1.5 mg kg−1 are required. Recommendations regarding the maximum allowable doses of local anaesthetics should consider population analysis to determine safer dosage ranges.

M. A. Corvetto – One of the best experts on this subject based on the ideXlab platform.

  • Levobupivacaine Absorption Pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: P. Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Purpose Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Methods Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. Results A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  

  • levobupivacaine Absorption Pharmacokinetics with and without epinephrine during tap block analysis of doses based on the associated risk of local anaesthetic toxicity
    European Journal of Clinical Pharmacology, 2016
    Co-Authors: Pablo A Miranda, M. A. Corvetto, Fernando R. Altermatt, A. Araneda, G. C. Echevarría, L. I. Cortínez
    Abstract:

    Cases of local anaesthetic systemic toxicity (LAST) periodically occur following transversus abdominal plane (TAP) blocks. The aim of this study was to characterize levobupivacaine Absorption Pharmacokinetics, with and without epinephrine, and estimate the risk of LAST, based on a previously reported toxic threshold. Previously reported data from 11 volunteers receiving ultrasound-guided TAP blocks with and without epinephrine on two independent occasions were analysed. Serial venous concentrations were measured for 90 min. A pharmacokinetic analysis was performed using the NONMEM statistical programme. The use of epinephrine in the solution was included in the analysis of covariates. The associated risk of LAST symptoms associated with different levobupivacaine dose schemes with and without epinephrine was estimated in 1000 simulated subjects. A one-compartment first-order input and elimination model adequately fit the levobupivacaine data. Epinephrine prolonged the levobupivacaine Absorption half-life {4.22 [95 % confidence interval (CI) 2.53–6.50] vs. 7.02 [95 % CI 3.74–14.1]; p  1.5 mg kg−1 are required. Recommendations regarding the maximum allowable doses of local anaesthetics should consider population analysis to determine safer dosage ranges.