The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Daniel Candaele - One of the best experts on this subject based on the ideXlab platform.
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once twice or three times daily famciclovir compared with Aciclovir for the oral treatment of herpes zoster in immunocompetent adults a randomized multicenter double blind clinical trial
Journal of Clinical Virology, 2004Co-Authors: Stephen D Shafran, Stephen K Tyring, Richard Ashton, Jacque Decroix, Chistine Forszpaniak, Alan Wade, Christian Paulet, Daniel CandaeleAbstract:Abstract Background: Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily. Because the intracellular half-life of penciclovir Triphosphate in varicella-zoster virus (VZV)-infected cells (7h) is considerably longer than that of Aciclovir Triphosphate (1h), it may be possible to administer famciclovir less frequently than three times daily for herpes zoster: Aciclovir is administered five times daily. Methods: 559 immunocompetent adults presenting with herpes zoster whose skin lesions were present for less than 72h were randomized to receive famciclovir 750mg once daily (od), 500mg twice daily (bid), or 250mg three times daily (tid), or Aciclovir 800mg five times daily. All treatments were given for 7 days. Participants were evaluated until complete healing or for 4 weeks, whichever occurred first. Results: There were no significant differences between the four treatment groups with respect to times to full crusting; loss of vesicles, ulcers and crusts; cessation of new lesion formation; a 50% reduction in the area of affected skin; and the loss of acute pain. Conclusions: Famciclovir 750mg once daily, 500mg twice daily and 250mg daily, and Aciclovir 800mg five times daily are three times comparable in efficacy with respect to the cutaneous healing of herpes zoster. The current study was not designed to assess the effects of the treatments on postherpetic neuralgia (PHN).
Stephen D Shafran - One of the best experts on this subject based on the ideXlab platform.
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once twice or three times daily famciclovir compared with Aciclovir for the oral treatment of herpes zoster in immunocompetent adults a randomized multicenter double blind clinical trial
Journal of Clinical Virology, 2004Co-Authors: Stephen D Shafran, Stephen K Tyring, Richard Ashton, Jacque Decroix, Chistine Forszpaniak, Alan Wade, Christian Paulet, Daniel CandaeleAbstract:Abstract Background: Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily. Because the intracellular half-life of penciclovir Triphosphate in varicella-zoster virus (VZV)-infected cells (7h) is considerably longer than that of Aciclovir Triphosphate (1h), it may be possible to administer famciclovir less frequently than three times daily for herpes zoster: Aciclovir is administered five times daily. Methods: 559 immunocompetent adults presenting with herpes zoster whose skin lesions were present for less than 72h were randomized to receive famciclovir 750mg once daily (od), 500mg twice daily (bid), or 250mg three times daily (tid), or Aciclovir 800mg five times daily. All treatments were given for 7 days. Participants were evaluated until complete healing or for 4 weeks, whichever occurred first. Results: There were no significant differences between the four treatment groups with respect to times to full crusting; loss of vesicles, ulcers and crusts; cessation of new lesion formation; a 50% reduction in the area of affected skin; and the loss of acute pain. Conclusions: Famciclovir 750mg once daily, 500mg twice daily and 250mg daily, and Aciclovir 800mg five times daily are three times comparable in efficacy with respect to the cutaneous healing of herpes zoster. The current study was not designed to assess the effects of the treatments on postherpetic neuralgia (PHN).
Stephen K Tyring - One of the best experts on this subject based on the ideXlab platform.
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once twice or three times daily famciclovir compared with Aciclovir for the oral treatment of herpes zoster in immunocompetent adults a randomized multicenter double blind clinical trial
Journal of Clinical Virology, 2004Co-Authors: Stephen D Shafran, Stephen K Tyring, Richard Ashton, Jacque Decroix, Chistine Forszpaniak, Alan Wade, Christian Paulet, Daniel CandaeleAbstract:Abstract Background: Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily. Because the intracellular half-life of penciclovir Triphosphate in varicella-zoster virus (VZV)-infected cells (7h) is considerably longer than that of Aciclovir Triphosphate (1h), it may be possible to administer famciclovir less frequently than three times daily for herpes zoster: Aciclovir is administered five times daily. Methods: 559 immunocompetent adults presenting with herpes zoster whose skin lesions were present for less than 72h were randomized to receive famciclovir 750mg once daily (od), 500mg twice daily (bid), or 250mg three times daily (tid), or Aciclovir 800mg five times daily. All treatments were given for 7 days. Participants were evaluated until complete healing or for 4 weeks, whichever occurred first. Results: There were no significant differences between the four treatment groups with respect to times to full crusting; loss of vesicles, ulcers and crusts; cessation of new lesion formation; a 50% reduction in the area of affected skin; and the loss of acute pain. Conclusions: Famciclovir 750mg once daily, 500mg twice daily and 250mg daily, and Aciclovir 800mg five times daily are three times comparable in efficacy with respect to the cutaneous healing of herpes zoster. The current study was not designed to assess the effects of the treatments on postherpetic neuralgia (PHN).
Richard Ashton - One of the best experts on this subject based on the ideXlab platform.
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once twice or three times daily famciclovir compared with Aciclovir for the oral treatment of herpes zoster in immunocompetent adults a randomized multicenter double blind clinical trial
Journal of Clinical Virology, 2004Co-Authors: Stephen D Shafran, Stephen K Tyring, Richard Ashton, Jacque Decroix, Chistine Forszpaniak, Alan Wade, Christian Paulet, Daniel CandaeleAbstract:Abstract Background: Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily. Because the intracellular half-life of penciclovir Triphosphate in varicella-zoster virus (VZV)-infected cells (7h) is considerably longer than that of Aciclovir Triphosphate (1h), it may be possible to administer famciclovir less frequently than three times daily for herpes zoster: Aciclovir is administered five times daily. Methods: 559 immunocompetent adults presenting with herpes zoster whose skin lesions were present for less than 72h were randomized to receive famciclovir 750mg once daily (od), 500mg twice daily (bid), or 250mg three times daily (tid), or Aciclovir 800mg five times daily. All treatments were given for 7 days. Participants were evaluated until complete healing or for 4 weeks, whichever occurred first. Results: There were no significant differences between the four treatment groups with respect to times to full crusting; loss of vesicles, ulcers and crusts; cessation of new lesion formation; a 50% reduction in the area of affected skin; and the loss of acute pain. Conclusions: Famciclovir 750mg once daily, 500mg twice daily and 250mg daily, and Aciclovir 800mg five times daily are three times comparable in efficacy with respect to the cutaneous healing of herpes zoster. The current study was not designed to assess the effects of the treatments on postherpetic neuralgia (PHN).
Jacque Decroix - One of the best experts on this subject based on the ideXlab platform.
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once twice or three times daily famciclovir compared with Aciclovir for the oral treatment of herpes zoster in immunocompetent adults a randomized multicenter double blind clinical trial
Journal of Clinical Virology, 2004Co-Authors: Stephen D Shafran, Stephen K Tyring, Richard Ashton, Jacque Decroix, Chistine Forszpaniak, Alan Wade, Christian Paulet, Daniel CandaeleAbstract:Abstract Background: Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily. Because the intracellular half-life of penciclovir Triphosphate in varicella-zoster virus (VZV)-infected cells (7h) is considerably longer than that of Aciclovir Triphosphate (1h), it may be possible to administer famciclovir less frequently than three times daily for herpes zoster: Aciclovir is administered five times daily. Methods: 559 immunocompetent adults presenting with herpes zoster whose skin lesions were present for less than 72h were randomized to receive famciclovir 750mg once daily (od), 500mg twice daily (bid), or 250mg three times daily (tid), or Aciclovir 800mg five times daily. All treatments were given for 7 days. Participants were evaluated until complete healing or for 4 weeks, whichever occurred first. Results: There were no significant differences between the four treatment groups with respect to times to full crusting; loss of vesicles, ulcers and crusts; cessation of new lesion formation; a 50% reduction in the area of affected skin; and the loss of acute pain. Conclusions: Famciclovir 750mg once daily, 500mg twice daily and 250mg daily, and Aciclovir 800mg five times daily are three times comparable in efficacy with respect to the cutaneous healing of herpes zoster. The current study was not designed to assess the effects of the treatments on postherpetic neuralgia (PHN).
