The Experts below are selected from a list of 13368 Experts worldwide ranked by ideXlab platform
Xianzheng Zhang - One of the best experts on this subject based on the ideXlab platform.
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super ph sensitive mesoporous silica nanoparticle based drug delivery system for effective combination cancer therapy
ACS Biomaterials Science & Engineering, 2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX...
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Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy
2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP nanoparticles exhibited the preferred cytotoxicity toward αvβ3-positive human cervical carcinoma (HeLa) cells. We believe that the multifunctional dual-stimuli-sensitive MSN could provide an effective strategy for combinational tumor therapy
Shyamal K Saha - One of the best experts on this subject based on the ideXlab platform.
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sulfuric acid doped poly diaminopyridine graphene composite to remove high concentration of toxic cr vi
Journal of Hazardous Materials, 2015Co-Authors: Diptiman Dinda, Shyamal K SahaAbstract:Abstract Sulfuric acid doped diaminopyridine polymers are synthesized in situ on graphene oxide surface via mutual oxidation–reduction technique. Exploiting large and highly porous surface, we have used this polymer composite as an adsorbent to remove high concentration of toxic Cr(VI) from water. It shows very high adsorption capacity (609.76 mg g −1 ) during removal process. The composite takes only 100 min to remove high concentration of 500 mg L −1 Cr(VI) from water. Interesting features for this material is the enhancement of removal efficiency at lower Acidic Condition due to the formation of acid doped emeraldine salt during polymerization. XPS and AAS measurements reveal that our prepared material mainly follows reduction mechanism at higher Acidic Condition while anions exchange mechanism at lower Acidic Condition during the removal experiments. Good recycling ability with ∼92% removal efficiency after fifth cycle is also noticed for this material. Easy preparation, superior stability in Acidic Condition, remarkable removal efficiency and excellent recycling ability make this polymer composite an efficient material for modern filtration units in waste water purification.
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sulfuric acid doped poly diaminopyridine graphene composite to remove high concentration of toxic cr vi
Journal of Hazardous Materials, 2015Co-Authors: Diptiman Dinda, Shyamal K SahaAbstract:Abstract Sulfuric acid doped diaminopyridine polymers are synthesized in situ on graphene oxide surface via mutual oxidation–reduction technique. Exploiting large and highly porous surface, we have used this polymer composite as an adsorbent to remove high concentration of toxic Cr(VI) from water. It shows very high adsorption capacity (609.76 mg g −1 ) during removal process. The composite takes only 100 min to remove high concentration of 500 mg L −1 Cr(VI) from water. Interesting features for this material is the enhancement of removal efficiency at lower Acidic Condition due to the formation of acid doped emeraldine salt during polymerization. XPS and AAS measurements reveal that our prepared material mainly follows reduction mechanism at higher Acidic Condition while anions exchange mechanism at lower Acidic Condition during the removal experiments. Good recycling ability with ∼92% removal efficiency after fifth cycle is also noticed for this material. Easy preparation, superior stability in Acidic Condition, remarkable removal efficiency and excellent recycling ability make this polymer composite an efficient material for modern filtration units in waste water purification.
Yinjia Cheng - One of the best experts on this subject based on the ideXlab platform.
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super ph sensitive mesoporous silica nanoparticle based drug delivery system for effective combination cancer therapy
ACS Biomaterials Science & Engineering, 2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX...
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Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy
2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP nanoparticles exhibited the preferred cytotoxicity toward αvβ3-positive human cervical carcinoma (HeLa) cells. We believe that the multifunctional dual-stimuli-sensitive MSN could provide an effective strategy for combinational tumor therapy
Diptiman Dinda - One of the best experts on this subject based on the ideXlab platform.
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sulfuric acid doped poly diaminopyridine graphene composite to remove high concentration of toxic cr vi
Journal of Hazardous Materials, 2015Co-Authors: Diptiman Dinda, Shyamal K SahaAbstract:Abstract Sulfuric acid doped diaminopyridine polymers are synthesized in situ on graphene oxide surface via mutual oxidation–reduction technique. Exploiting large and highly porous surface, we have used this polymer composite as an adsorbent to remove high concentration of toxic Cr(VI) from water. It shows very high adsorption capacity (609.76 mg g −1 ) during removal process. The composite takes only 100 min to remove high concentration of 500 mg L −1 Cr(VI) from water. Interesting features for this material is the enhancement of removal efficiency at lower Acidic Condition due to the formation of acid doped emeraldine salt during polymerization. XPS and AAS measurements reveal that our prepared material mainly follows reduction mechanism at higher Acidic Condition while anions exchange mechanism at lower Acidic Condition during the removal experiments. Good recycling ability with ∼92% removal efficiency after fifth cycle is also noticed for this material. Easy preparation, superior stability in Acidic Condition, remarkable removal efficiency and excellent recycling ability make this polymer composite an efficient material for modern filtration units in waste water purification.
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sulfuric acid doped poly diaminopyridine graphene composite to remove high concentration of toxic cr vi
Journal of Hazardous Materials, 2015Co-Authors: Diptiman Dinda, Shyamal K SahaAbstract:Abstract Sulfuric acid doped diaminopyridine polymers are synthesized in situ on graphene oxide surface via mutual oxidation–reduction technique. Exploiting large and highly porous surface, we have used this polymer composite as an adsorbent to remove high concentration of toxic Cr(VI) from water. It shows very high adsorption capacity (609.76 mg g −1 ) during removal process. The composite takes only 100 min to remove high concentration of 500 mg L −1 Cr(VI) from water. Interesting features for this material is the enhancement of removal efficiency at lower Acidic Condition due to the formation of acid doped emeraldine salt during polymerization. XPS and AAS measurements reveal that our prepared material mainly follows reduction mechanism at higher Acidic Condition while anions exchange mechanism at lower Acidic Condition during the removal experiments. Good recycling ability with ∼92% removal efficiency after fifth cycle is also noticed for this material. Easy preparation, superior stability in Acidic Condition, remarkable removal efficiency and excellent recycling ability make this polymer composite an efficient material for modern filtration units in waste water purification.
Aiqing Zhang - One of the best experts on this subject based on the ideXlab platform.
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super ph sensitive mesoporous silica nanoparticle based drug delivery system for effective combination cancer therapy
ACS Biomaterials Science & Engineering, 2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX...
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Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy
2019Co-Authors: Yinjia Cheng, Siyong Qin, Xiaosui Chen, Aiqing Zhang, Xianzheng ZhangAbstract:A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via physical absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly Acidic Condition (pH 6.8) and superior stability in physiological environment (pH 7.4). According to the drug release research, both glutathione (GSH) and Acidic Condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP nanoparticles exhibited the preferred cytotoxicity toward αvβ3-positive human cervical carcinoma (HeLa) cells. We believe that the multifunctional dual-stimuli-sensitive MSN could provide an effective strategy for combinational tumor therapy
