The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Harley S Smyth - One of the best experts on this subject based on the ideXlab platform.
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hormone secretion in vitro by plurihormonal pituitary adenomas of the Acidophil Cell line
The Journal of Clinical Endocrinology and Metabolism, 1992Co-Authors: Sylvia L Asa, K Kovacs, Eva Horvath, William Singer, Harley S SmythAbstract:Pituitary tumors producing GH and PRL are morphologically classified as monomorphous bihormonal Acidophil stem Cell adenomas (ASCAs) which cause hyperprolactinemia and two tumor types which are usually associated with acromegaly, the monomorphous plurihormonal mammosomatotroph adenomas (MSAs) and bimorphous mixed somatotroph-lactotroph adenomas. We studied 12 MSAs, 2 ASCAs, and 10 mixed adenomas in vitro to assess the secretory behavior of these tumors diagnosed by immunohistochemistry and electron microscopy. GH release by MSAs and all but one mixed tumor was greater than that of PRL; the opposite was true of the ASCAs. One mixed tumor which caused impotence and hyperprolactinemia contained predominantly lactotrophs and released greater amounts of PRL than of GH in vitro. All 12 MSAs and 6 of 10 mixed tumors released alpha-subunit of glycoprotein hormones. Incubation with GHRH increased release of GH and PRL by all tumors and of alpha-subunit when present; the responses of all hormones were parallel amon...
Sylvia L Asa - One of the best experts on this subject based on the ideXlab platform.
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hormone secretion in vitro by plurihormonal pituitary adenomas of the Acidophil Cell line
The Journal of Clinical Endocrinology and Metabolism, 1992Co-Authors: Sylvia L Asa, K Kovacs, Eva Horvath, William Singer, Harley S SmythAbstract:Pituitary tumors producing GH and PRL are morphologically classified as monomorphous bihormonal Acidophil stem Cell adenomas (ASCAs) which cause hyperprolactinemia and two tumor types which are usually associated with acromegaly, the monomorphous plurihormonal mammosomatotroph adenomas (MSAs) and bimorphous mixed somatotroph-lactotroph adenomas. We studied 12 MSAs, 2 ASCAs, and 10 mixed adenomas in vitro to assess the secretory behavior of these tumors diagnosed by immunohistochemistry and electron microscopy. GH release by MSAs and all but one mixed tumor was greater than that of PRL; the opposite was true of the ASCAs. One mixed tumor which caused impotence and hyperprolactinemia contained predominantly lactotrophs and released greater amounts of PRL than of GH in vitro. All 12 MSAs and 6 of 10 mixed tumors released alpha-subunit of glycoprotein hormones. Incubation with GHRH increased release of GH and PRL by all tumors and of alpha-subunit when present; the responses of all hormones were parallel amon...
William Singer - One of the best experts on this subject based on the ideXlab platform.
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hormone secretion in vitro by plurihormonal pituitary adenomas of the Acidophil Cell line
The Journal of Clinical Endocrinology and Metabolism, 1992Co-Authors: Sylvia L Asa, K Kovacs, Eva Horvath, William Singer, Harley S SmythAbstract:Pituitary tumors producing GH and PRL are morphologically classified as monomorphous bihormonal Acidophil stem Cell adenomas (ASCAs) which cause hyperprolactinemia and two tumor types which are usually associated with acromegaly, the monomorphous plurihormonal mammosomatotroph adenomas (MSAs) and bimorphous mixed somatotroph-lactotroph adenomas. We studied 12 MSAs, 2 ASCAs, and 10 mixed adenomas in vitro to assess the secretory behavior of these tumors diagnosed by immunohistochemistry and electron microscopy. GH release by MSAs and all but one mixed tumor was greater than that of PRL; the opposite was true of the ASCAs. One mixed tumor which caused impotence and hyperprolactinemia contained predominantly lactotrophs and released greater amounts of PRL than of GH in vitro. All 12 MSAs and 6 of 10 mixed tumors released alpha-subunit of glycoprotein hormones. Incubation with GHRH increased release of GH and PRL by all tumors and of alpha-subunit when present; the responses of all hormones were parallel amon...
Eva Horvath - One of the best experts on this subject based on the ideXlab platform.
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hormone secretion in vitro by plurihormonal pituitary adenomas of the Acidophil Cell line
The Journal of Clinical Endocrinology and Metabolism, 1992Co-Authors: Sylvia L Asa, K Kovacs, Eva Horvath, William Singer, Harley S SmythAbstract:Pituitary tumors producing GH and PRL are morphologically classified as monomorphous bihormonal Acidophil stem Cell adenomas (ASCAs) which cause hyperprolactinemia and two tumor types which are usually associated with acromegaly, the monomorphous plurihormonal mammosomatotroph adenomas (MSAs) and bimorphous mixed somatotroph-lactotroph adenomas. We studied 12 MSAs, 2 ASCAs, and 10 mixed adenomas in vitro to assess the secretory behavior of these tumors diagnosed by immunohistochemistry and electron microscopy. GH release by MSAs and all but one mixed tumor was greater than that of PRL; the opposite was true of the ASCAs. One mixed tumor which caused impotence and hyperprolactinemia contained predominantly lactotrophs and released greater amounts of PRL than of GH in vitro. All 12 MSAs and 6 of 10 mixed tumors released alpha-subunit of glycoprotein hormones. Incubation with GHRH increased release of GH and PRL by all tumors and of alpha-subunit when present; the responses of all hormones were parallel amon...
K Kovacs - One of the best experts on this subject based on the ideXlab platform.
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hormone secretion in vitro by plurihormonal pituitary adenomas of the Acidophil Cell line
The Journal of Clinical Endocrinology and Metabolism, 1992Co-Authors: Sylvia L Asa, K Kovacs, Eva Horvath, William Singer, Harley S SmythAbstract:Pituitary tumors producing GH and PRL are morphologically classified as monomorphous bihormonal Acidophil stem Cell adenomas (ASCAs) which cause hyperprolactinemia and two tumor types which are usually associated with acromegaly, the monomorphous plurihormonal mammosomatotroph adenomas (MSAs) and bimorphous mixed somatotroph-lactotroph adenomas. We studied 12 MSAs, 2 ASCAs, and 10 mixed adenomas in vitro to assess the secretory behavior of these tumors diagnosed by immunohistochemistry and electron microscopy. GH release by MSAs and all but one mixed tumor was greater than that of PRL; the opposite was true of the ASCAs. One mixed tumor which caused impotence and hyperprolactinemia contained predominantly lactotrophs and released greater amounts of PRL than of GH in vitro. All 12 MSAs and 6 of 10 mixed tumors released alpha-subunit of glycoprotein hormones. Incubation with GHRH increased release of GH and PRL by all tumors and of alpha-subunit when present; the responses of all hormones were parallel amon...
