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Acoustic Scattering

The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

Scott R Manalis – 1st expert on this subject based on the ideXlab platform

  • noninvasive monitoring of single cell mechanics by Acoustic Scattering
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of < 1 min. Through simulations, experiments with hydrogels and the use of chemically perturbed cells, we show that our readout, the size-normalized Acoustic Scattering (SNACS), measures stiffness. To demonstrate the noninvasiveness of SNACS over successive cell cycles, we used measurements that resulted in deformations of < 15 nm. The cells maintained constant SNACS throughout interphase but showed dynamic changes during mitosis. Our work provides a basis for understanding how growing cells maintain mechanical integrity, and demonstrates that Acoustic Scattering can be used to noninvasively probe subtle and transient dynamics. Acoustic Scattering in a suspended microchannel resonator can be used to measure mechanical properties of single cells in a noninvasive manner. The approach is applied to follow stiffness changes of individual cells throughout the cell cycle.

  • Noninvasive monitoring of single-cell mechanics by Acoustic Scattering.
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of 

Teemu P Miettinen – 2nd expert on this subject based on the ideXlab platform

  • noninvasive monitoring of single cell mechanics by Acoustic Scattering
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of < 1 min. Through simulations, experiments with hydrogels and the use of chemically perturbed cells, we show that our readout, the size-normalized Acoustic Scattering (SNACS), measures stiffness. To demonstrate the noninvasiveness of SNACS over successive cell cycles, we used measurements that resulted in deformations of < 15 nm. The cells maintained constant SNACS throughout interphase but showed dynamic changes during mitosis. Our work provides a basis for understanding how growing cells maintain mechanical integrity, and demonstrates that Acoustic Scattering can be used to noninvasively probe subtle and transient dynamics. Acoustic Scattering in a suspended microchannel resonator can be used to measure mechanical properties of single cells in a noninvasive manner. The approach is applied to follow stiffness changes of individual cells throughout the cell cycle.

  • Noninvasive monitoring of single-cell mechanics by Acoustic Scattering.
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of 

Joon Ho Kang – 3rd expert on this subject based on the ideXlab platform

  • noninvasive monitoring of single cell mechanics by Acoustic Scattering
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of < 1 min. Through simulations, experiments with hydrogels and the use of chemically perturbed cells, we show that our readout, the size-normalized Acoustic Scattering (SNACS), measures stiffness. To demonstrate the noninvasiveness of SNACS over successive cell cycles, we used measurements that resulted in deformations of < 15 nm. The cells maintained constant SNACS throughout interphase but showed dynamic changes during mitosis. Our work provides a basis for understanding how growing cells maintain mechanical integrity, and demonstrates that Acoustic Scattering can be used to noninvasively probe subtle and transient dynamics. Acoustic Scattering in a suspended microchannel resonator can be used to measure mechanical properties of single cells in a noninvasive manner. The approach is applied to follow stiffness changes of individual cells throughout the cell cycle.

  • Noninvasive monitoring of single-cell mechanics by Acoustic Scattering.
    Nature Methods, 2019
    Co-Authors: Joon Ho Kang, Teemu P Miettinen, Lynna Chen, Selim Olcum, Georgios Katsikis, Patrick S Doyle, Scott R Manalis

    Abstract:

    The monitoring of mechanics in a single cell throughout the cell cycle has been hampered by the invasiveness of mechanical measurements. Here we quantify mechanical properties via Acoustic Scattering of waves from a cell inside a fluid-filled vibrating cantilever with a temporal resolution of