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Acronycine

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Francois Tillequin – One of the best experts on this subject based on the ideXlab platform.

  • troger s bases in the Acronycine benzo a Acronycine and benzo b Acronycine series
    Tetrahedron Letters, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Francois Tillequin

    Abstract:

    Abstract Reaction of 11-aminoAcronycine, 10-aminobenzo[ a ]Acronycine, and 10-aminobenzo[ b ]Acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, Acronycine, benzo[ a ]Acronycine, and benzo[ b ]Acronycine.

  • Synthesis and Cytotoxic Activity of Benzo[a]Acronycine and Benzo[b]Acronycine Substituted on the A Ring.
    ChemInform, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Fabiola Covello, Laura Velazquez-alonso, Francois Tillequin

    Abstract:

    Novel benzo[a]Acronycine (VIII) and benzo[b]Acronycine (IX) derivatives substituted in 10-position are synthesized following a similar strategy.

  • Tröger’s bases in the Acronycine, benzo[a]Acronycine, and benzo[b]Acronycine series
    Tetrahedron Letters, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Francois Tillequin

    Abstract:

    Abstract Reaction of 11-aminoAcronycine, 10-aminobenzo[ a ]Acronycine, and 10-aminobenzo[ b ]Acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, Acronycine, benzo[ a ]Acronycine, and benzo[ b ]Acronycine.

Sylvie Michel – One of the best experts on this subject based on the ideXlab platform.

  • troger s bases in the Acronycine benzo a Acronycine and benzo b Acronycine series
    Tetrahedron Letters, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Francois Tillequin

    Abstract:

    Abstract Reaction of 11-aminoAcronycine, 10-aminobenzo[ a ]Acronycine, and 10-aminobenzo[ b ]Acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, Acronycine, benzo[ a ]Acronycine, and benzo[ b ]Acronycine.

  • Synthesis and Cytotoxic Activity of Benzo[a]Acronycine and Benzo[b]Acronycine Substituted on the A Ring.
    ChemInform, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Fabiola Covello, Laura Velazquez-alonso, Francois Tillequin

    Abstract:

    Novel benzo[a]Acronycine (VIII) and benzo[b]Acronycine (IX) derivatives substituted in 10-position are synthesized following a similar strategy.

  • Tröger’s bases in the Acronycine, benzo[a]Acronycine, and benzo[b]Acronycine series
    Tetrahedron Letters, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Francois Tillequin

    Abstract:

    Abstract Reaction of 11-aminoAcronycine, 10-aminobenzo[ a ]Acronycine, and 10-aminobenzo[ b ]Acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, Acronycine, benzo[ a ]Acronycine, and benzo[ b ]Acronycine.

Stephane Leonce – One of the best experts on this subject based on the ideXlab platform.

  • Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one Analogs of Acronycine
    Journal of Medicinal Chemistry, 2014
    Co-Authors: Wen Tian, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Laurence Kraus-berthier, Rodrigue Yougnia, Marie-hélène David-cordonnier, Sabine Depauw, Amélie Lansiaux, Hanh Dufat

    Abstract:

    A series of 6-methoxy-3,3,14-trimethyl-3,14-dihydro-7H-benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one (4), 13-aza derivatives of benzo[b]Acronycine, the isomeric 5-methoxy-2,2,13-trimethyl-2,13-dihydro-6H-benzo[b]chromeno[7,6-g][1,8]naphthyridin-6-one (5), and related cis-diols mono- and diesters were designed and synthesized. Their in vitro and in vivo biological activities were evaluated. As previously observed in the Acronycine series, esters were the most potent derivatives exhibiting submicromolar activities; among them monoesters are particularly active. Racemic diacetate 21 showed a strong activity against KB-3-1 cell lines and was selected for in vivo evaluation and proved to be active, inhibiting tumor growth by more than 80%. After separation of the two enantiomers, compounds 21a and 21b were also evaluated against C38 colon adenocarcinoma; their activities were found to be significantly different.

  • troger s bases in the Acronycine benzo a Acronycine and benzo b Acronycine series
    Tetrahedron Letters, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Francois Tillequin

    Abstract:

    Abstract Reaction of 11-aminoAcronycine, 10-aminobenzo[ a ]Acronycine, and 10-aminobenzo[ b ]Acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, Acronycine, benzo[ a ]Acronycine, and benzo[ b ]Acronycine.

  • Synthesis and Cytotoxic Activity of Benzo[a]Acronycine and Benzo[b]Acronycine Substituted on the A Ring.
    ChemInform, 2011
    Co-Authors: Thomas Gaslonde, Bruno Pfeiffer, Stephane Leonce, Alain Pierré, Sylvie Michel, Fabiola Covello, Laura Velazquez-alonso, Francois Tillequin

    Abstract:

    Novel benzo[a]Acronycine (VIII) and benzo[b]Acronycine (IX) derivatives substituted in 10-position are synthesized following a similar strategy.