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Activated Macrophage

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Jenkun Lin – One of the best experts on this subject based on the ideXlab platform.

Min-hsiung Pan – One of the best experts on this subject based on the ideXlab platform.

Jer Huei Lin – One of the best experts on this subject based on the ideXlab platform.

  • Suppression of lipopolysaccharide-induced nuclear factor-κB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IκB kinase activity in Macrophages
    Biochemical pharmacology, 2000
    Co-Authors: Min-hsiung Pan, Shoei-yn Lin-shiau, Jer Huei Lin, Jenkun Lin
    Abstract:

    We investigated the inhibition of IkappaB kinase (IKK) activity in lipopolysaccharide (LPS)-Activated murine Macrophages (RAW 264.7 cell line) by various polyphenols including (-)-epigallocatechin-3-gallate, theaflavin, a mixture of theaflavin-3 gallate and theaflavin-3′-gallate, theaflavin-3,3′-digallate (TF-3), pyrocyanidin B-3, casuarinin, geraniin, and penta-O-galloyl-beta-D-glucose (5GG). TF-3 inhibited IKK activity in Activated Macrophages more strongly than did the other polyphenols. TF-3 strongly inhibited both IKK1 and IKK2 activity and prevented the degradation of IkappaBalpha and IkappaBbeta in Activated Macrophage cells. The results suggested that the inhibition of IKK activity by TF-3 could occur by a direct effect on IKKs or on upstream events in the signal transduction pathway. Furthermore, geraniin, 5GG, and TF-3 all blocked phosphorylation of IKB from the cytosolic fraction, inhibited nuclear factor-kappaB (NFkappaB) activity, and inhibited increases in inducible nitric oxide synthase levels in Activated Macrophages. These results suggest that TF-3 may exert its anti-inflammatory and cancer chemopreventive actions by suppressing the activation of NFkappaB through inhibition of IKK activity.

  • suppression of lipopolysaccharide induced nuclear factor κb activity by theaflavin 3 3 digallate from black tea and other polyphenols through down regulation of iκb kinase activity in Macrophages
    Biochemical Pharmacology, 2000
    Co-Authors: Min-hsiung Pan, Jer Huei Lin, Shoeiyn Linshiau, Jenkun Lin
    Abstract:

    We investigated the inhibition of IkappaB kinase (IKK) activity in lipopolysaccharide (LPS)-Activated murine Macrophages (RAW 264.7 cell line) by various polyphenols including (-)-epigallocatechin-3-gallate, theaflavin, a mixture of theaflavin-3 gallate and theaflavin-3′-gallate, theaflavin-3,3′-digallate (TF-3), pyrocyanidin B-3, casuarinin, geraniin, and penta-O-galloyl-beta-D-glucose (5GG). TF-3 inhibited IKK activity in Activated Macrophages more strongly than did the other polyphenols. TF-3 strongly inhibited both IKK1 and IKK2 activity and prevented the degradation of IkappaBalpha and IkappaBbeta in Activated Macrophage cells. The results suggested that the inhibition of IKK activity by TF-3 could occur by a direct effect on IKKs or on upstream events in the signal transduction pathway. Furthermore, geraniin, 5GG, and TF-3 all blocked phosphorylation of IKB from the cytosolic fraction, inhibited nuclear factor-kappaB (NFkappaB) activity, and inhibited increases in inducible nitric oxide synthase levels in Activated Macrophages. These results suggest that TF-3 may exert its anti-inflammatory and cancer chemopreventive actions by suppressing the activation of NFkappaB through inhibition of IKK activity.

Yajun Duan – One of the best experts on this subject based on the ideXlab platform.

Makoto Shimizu – One of the best experts on this subject based on the ideXlab platform.