The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform
Andras Foldesi - One of the best experts on this subject based on the ideXlab platform.
-
carba lna 5mec a g t modified oligos show nucleobase specific modulation of 3 exonuclease Activity Thermodynamic stability rna selectivity and rnase h elicitation synthesis and biochemistry
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
-
Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease Activity, Thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
Ramshankar Upadhayaya - One of the best experts on this subject based on the ideXlab platform.
-
carba lna 5mec a g t modified oligos show nucleobase specific modulation of 3 exonuclease Activity Thermodynamic stability rna selectivity and rnase h elicitation synthesis and biochemistry
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
-
Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease Activity, Thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
Maria Grzeszczuk - One of the best experts on this subject based on the ideXlab platform.
-
Electrocrystallization of silver nanoparticles from silver halides in polypyrrole evidenced by their SERS Activity—Thermodynamic and kinetic conditions
Journal of Solid State Electrochemistry, 2018Co-Authors: Kamil Wójcik, Tomasz Czaja, Roman Szostak, Maria GrzeszczukAbstract:Silver(I) halide particles embodied in polypyrrole matrices are synthesized and further processed electrochemically to get nanoparticles of silver with significant Activity in the surface-enhanced Raman spectroscopy (SERS) of the rhodamine 6G test solute, which is considered as a clear evidence of Ag nanocrystallization. The electrocrystallization of Ag nanoparticles is analyzed using redox charges of composites determined from cyclic voltammograms recorded at various time scales and/or cycle numbers. Pristine PPy/AgX and modified PPy/AgX/AgNP composites are characterized using electrochemical impedance spectroscopy, scanning electron microscopy, and X-ray electron dispersive spectroscopy. The Thermodynamic and kinetic conditions of the electrochemical modification of pristine polypyrrole–AgX composites leading to the electrocrystallization of Ag nanoparticles are discussed.
Jinlin Long - One of the best experts on this subject based on the ideXlab platform.
-
Metal-Free Photocatalysts C3N3S3 and its Polymers: Solubility in Water and Application in Benzylic Alcohols Oxidation Under Visible Light
NANO, 2017Co-Authors: Liming Chen, Lulu Zhao, Jie Xu, Jinlin LongAbstract:Metal-free photocatalysts trithiocyanuric acid (C3N3S3) and its polymers were one-step synthesized and used for selective aerobic oxidation of benzyl alcohol under visible light. The S–S bridged C3N3S3 polymers showed higher oxidation Activity with increasing polymerization time and reached a maximum at 40h. As a major factor, catalysts’ solubility in water at different temperatures (from 298.15K to 368.15K) was measured at atmospheric pressure. The obtained data were correlated by polynomial empirical equation and modified Apelblat equation, respectively. Experimental results proved that the solubility of C3N3S3 and its polymers increased with increasing temperature. The solubility of C3N3S3 polymers with lower polymerization degree (DP) were better than that of parent C3N3S3 owing to the hydrophilicity caused by a low symmetry and disorder structure, whereas the higher DP could lead to the decrease of polymer solubility and further affect the photocatalytic Activity. Thermodynamic properties of the solution system including the enthalpy (ΔHS0) and heat capacity (cp0) were calculated by the modified Apelblat equation.
-
Metal-Free Photocatalysts C3N3S3 and its Polymers: Solubility in Water and Application in Benzylic Alcohols Oxidation Under Visible Light
Nano, 2017Co-Authors: Liming Chen, Lulu Zhao, Jie Xu, Jinlin LongAbstract:Metal-free photocatalysts trithiocyanuric acid (C3N3S[Formula: see text] and its polymers were one-step synthesized and used for selective aerobic oxidation of benzyl alcohol under visible light. The S–S bridged C3N3S3 polymers showed higher oxidation Activity with increasing polymerization time and reached a maximum at 40[Formula: see text]h. As a major factor, catalysts’ solubility in water at different temperatures (from 298.15[Formula: see text]K to 368.15[Formula: see text]K) was measured at atmospheric pressure. The obtained data were correlated by polynomial empirical equation and modified Apelblat equation, respectively. Experimental results proved that the solubility of C3N3S3 and its polymers increased with increasing temperature. The solubility of C3N3S3 polymers with lower polymerization degree (DP) were better than that of parent C3N3S3 owing to the hydrophilicity caused by a low symmetry and disorder structure, whereas the higher DP could lead to the decrease of polymer solubility and further affect the photocatalytic Activity. Thermodynamic properties of the solution system including the enthalpy ([Formula: see text] and heat capacity ([Formula: see text]) were calculated by the modified Apelblat equation.
Chuanzheng Zhou - One of the best experts on this subject based on the ideXlab platform.
-
carba lna 5mec a g t modified oligos show nucleobase specific modulation of 3 exonuclease Activity Thermodynamic stability rna selectivity and rnase h elicitation synthesis and biochemistry
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
-
Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease Activity, Thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Journal of Organic Chemistry, 2011Co-Authors: Ramshankar Upadhayaya, Sachin Gangadhar Deshpande, Qing Li, Ramakant A Kardile, Aftab Y Sayyed, Eknath Kamalakar Kshirsagar, Rahul Vilas Salunke, Shailesh S Dixit, Chuanzheng Zhou, Andras FoldesiAbstract:Using the intramolecular 5-exo-5-hexenyl radical as a key cyclization step, we previously reported an unambiguous synthesis of carba-LNA thymine (cLNA-T), which we subsequently incorporated in antisense oligonucleotides (AON) and investigated their biochemical properties [J. Am. Chem. Soc.2007, 129 (26), 8362–8379]. These cLNA-T incorporated oligos showed specific RNA affinity of +3.5–5 °C/modification for AON:RNA heteroduplexes, which is comparable to what is found for those of LNAs (Locked Nucleic Acids). These modified oligos however showed significantly enhanced nuclease stability (ca. 100 times more) in the blood serum compared to those of the LNA modified counterparts without compromising any RNase H recruitment capability. We herein report the synthesis of 5-methylcytosine-1-yl (MeC), 9-adeninyl (A), and 9-guaninyl (G) derivatives of cLNA and their oligonucleotides and report their biochemical properties as potential RNA-directed inhibitors. In a series of isosequential carba-LNA modified AONs, we ...
