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Thad Ghim - One of the best experts on this subject based on the ideXlab platform.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Journal of Korean Medical Science, 2006
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in Acute Leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Blood, 2005
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is con- troversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expres- sion are associated with outcomes in Acute Leukemia patients. At diagnosis we exam- ined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to - actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expres- sion was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remis- sion and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

Hee Jin Huh - One of the best experts on this subject based on the ideXlab platform.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Journal of Korean Medical Science, 2006
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in Acute Leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Blood, 2005
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is con- troversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expres- sion are associated with outcomes in Acute Leukemia patients. At diagnosis we exam- ined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to - actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expres- sion was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remis- sion and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

Chan Jeoung Park - One of the best experts on this subject based on the ideXlab platform.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Journal of Korean Medical Science, 2006
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in Acute Leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Blood, 2005
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is con- troversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expres- sion are associated with outcomes in Acute Leukemia patients. At diagnosis we exam- ined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to - actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expres- sion was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remis- sion and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

Seongsoo Jang - One of the best experts on this subject based on the ideXlab platform.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Journal of Korean Medical Science, 2006
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in Acute Leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Blood, 2005
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is con- troversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expres- sion are associated with outcomes in Acute Leukemia patients. At diagnosis we exam- ined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to - actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expres- sion was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remis- sion and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

Eul Ju Seo - One of the best experts on this subject based on the ideXlab platform.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Journal of Korean Medical Science, 2006
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in Acute Leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.

  • prognostic significance of multidrug resistance gene 1 mdr1 multidrug resistance related protein mrp and lung resistance protein lrp mrna expression in Acute Leukemia
    Blood, 2005
    Co-Authors: Hee Jin Huh, Chan Jeoung Park, Seongsoo Jang, Eul Ju Seo, Hyun Sook Chi, Jehwan Lee, Kyoo Hyung Lee, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
    Abstract:

    The prognostic significance of multidrug resistance (MDR) gene expression is con- troversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expres- sion are associated with outcomes in Acute Leukemia patients. At diagnosis we exam- ined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 Acute Leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to - actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in Acute Leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expres- sion was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remis- sion and survival rates in Acute Leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for Acute Leukemia patients.