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Acute Myelomonocytic Leukemia

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Carlos E Buesoramos – One of the best experts on this subject based on the ideXlab platform.

  • comparative analysis of genes regulated in Acute Myelomonocytic Leukemia with and without inv 16 p13q22 using microarray techniques real time pcr immunohistochemistry and flow cytometry immunophenotyping
    Modern Pathology, 2007
    Co-Authors: Xiaoping Sun, Wei Zhang, Latha Ramdas, David N Stivers, Dan Jones, Hagop M Kantarjian, Elihu H Estey, Saroj Vadhanraj, Jeffrey L Medeiros, Carlos E Buesoramos

    Abstract:

    Comparative analysis of genes regulated in Acute Myelomonocytic Leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping

  • Acute Myelomonocytic Leukemia with histologic features resembling sarcomatoid carcinoma in bone marrow
    Archives of Pathology & Laboratory Medicine, 2000
    Co-Authors: Walid H. Hamoudi, L. Jeffrey Medeiros, Gault Townsend, Armand B. Glassman, Carlos E Buesoramos

    Abstract:

    We report a case of primary Acute Myelomonocytic Leukemia involving the bone marrow that resembled sarcomatoid carcinoma. The neoplastic cells in bone marrow biopsy specimens formed cohesive-appearing clusters and cords separated by an immature fibroblastic proliferation and myxoid stroma. Blasts in the bone marrow aspirate smears formed clusters and sheets, and a subset of blasts exhibited erythrophagocytosis. Dysgranulopoiesis was also present. Lineage was confirmed by immunohistochemical analysis of formalin-fixed, paraffin-embedded tissue. The tumor cells showed strong reactivity for lysozyme, myeloperoxidase, CD45, and CD68 and were negative for keratin, S100, CD20, and CD3. The serum lysozyme concentration (110 microgram/mL) was 13 times greater than the normal value (8 microgram/mL). Cytogenetic studies performed on bone marrow aspirate material revealed a complex karyotype, including trisomy 8 and abnormalities of chromosome 11q. We report this case of Acute Myelomonocytic Leukemia because the neoplastic cells appeared cohesive and spindled, resembling sarcomatoid carcinoma, and therefore caused diagnostic difficulty. Other monocytic neoplasms with similar resemblance to carcinoma or sarcoma have been reported in the literature, suggesting that the tendency to appear cohesive may be an inherent characteristic of neoplastic cells with monocytic differentiation.

Felicetto Ferrara – One of the best experts on this subject based on the ideXlab platform.

  • Trisomy 4 and ring chromosome in a patient with Acute Myelomonocytic Leukemia.
    Haematologica, 1994
    Co-Authors: Laura Vicari, Lucia Sebastio, Mc Stanziola, A Fasanaro, Felicetto Ferrara

    Abstract:

    We describe a patient with Acute Myelomonocytic Leukemia (AMML) in whom cytogenetic analysis revealed trisomy 4 associated with a ring chromosome. In addition, in a cytogenetically unrelated clone, trisomy 8 and 5q- abnormalities were detectable. The possibility of a subclinical myelodysplastic syndrome preceding the onset of AML is discussed on the basis of the morphological and cytogenetic findings.

Laura Vicari – One of the best experts on this subject based on the ideXlab platform.

  • A novel chromosomal abnormality detected in a case of Acute Myelomonocytic Leukemia.
    Leukemia, 1994
    Co-Authors: Amedeo Fiorillo, Lucia Sebastio, L. Del Vecchio, R. Migliorati, C. De Chiara, Rosa D'amore, Laura Vicari, Annalisa Pastore, Carmine Selleri

    Abstract:

    A not yet recorded translocation, t(3:17)(q21;q23), detected in a case of Acute Myelomonocytic Leukemia, is reported. In spite of an aggressive cytotoxic chemotherapy, the disease showed a rapid fatal course, confirming the dismal prognostic significance of structural, ‘primary’ chromosomal abnormalities in Acute Leukemias.

  • Trisomy 4 and ring chromosome in a patient with Acute Myelomonocytic Leukemia.
    Haematologica, 1994
    Co-Authors: Laura Vicari, Lucia Sebastio, Mc Stanziola, A Fasanaro, Felicetto Ferrara

    Abstract:

    We describe a patient with Acute Myelomonocytic Leukemia (AMML) in whom cytogenetic analysis revealed trisomy 4 associated with a ring chromosome. In addition, in a cytogenetically unrelated clone, trisomy 8 and 5q- abnormalities were detectable. The possibility of a subclinical myelodysplastic syndrome preceding the onset of AML is discussed on the basis of the morphological and cytogenetic findings.