The Experts below are selected from a list of 2337 Experts worldwide ranked by ideXlab platform
Valérie B. Schini-kerth - One of the best experts on this subject based on the ideXlab platform.
-
O11 Endothelium-dependent relaxation by a hydroethanolic extract of Adansonia digitata leaves in porcine coronary artery rings and rat thoracic aorta, mesenteric, carotid artery rings: Role of NO and EDH
Biochemical Pharmacology, 2017Co-Authors: Mbaye Sene, M O Kane, A S Diallo, Hyun-ho Lee, Cyril Auger, Philippe Chabert, Catherine Vonthron-sénécheau, Valérie B. Schini-kerthAbstract:Introduction Adansonia digitata leaves are used for the traditional treatment of hypertension in Senegal. This study evaluated the relaxant effect of a hydroethanolic extract of leaves of Adansonia digitata (ADF) in artery rings, and investigated the underlying mechanism. Methods Vascular reactivity was assessed in organ chambers. Rings were either untreated or incubated with a pharmacological tool for 30 min before contraction of coronary artery rings with either U46619 or phenylephrine, and the subsequent addition of ADF. In some experiments, the endothelium was removed mechanically. The phosphorylation level of target proteins was assessed by Western blot analysis. Results ADF induced concentration-dependent relaxations in coronary artery rings with endothelium, which reached 100% at a concentration as low as 10 μg/ml. The relaxation to ADF was significantly reduced by NLA (NO synthase inhibitor) and by the combination of Tram-34 and apamin (inhibitors of intermediate and small conductance calcium-dependent K+ channels, respectively), not affected by indomethacin (cyclooxygenase inhibitor), and abolished by wortmannin (PI3-kinase inhibitor) and MnTMPyP (membrane permeant superoxide dismutase mimetic). ADF caused relaxations in the rat superior mesenteric artery, carotid artery and aortic rings but not in the secondary mesenteric artery and femoral artery rings. ADF induced a sustained phosphorylation of Akt and eNOS at Ser1177 in cultured porcine coronary artery endothelial cells. Conclusion The Adansonia digitata leave extract induced potent endothelium-dependent relaxations, involving predominantly NO and endothelium-dependent hyperpolarization. Such vasorelaxant effects may explain the antihypertensive use of this plant in traditional African medicine.
Clement O. Bewaji - One of the best experts on this subject based on the ideXlab platform.
-
Activity of Adansonia digitata on biochemical and hematological changes in established Plasmodium berghei -infected mice
Comparative Clinical Pathology, 2019Co-Authors: Akinwunmi O. Adeoye, Clement O. BewajiAbstract:The intra-erythrocytic lifestyle of malaria parasite contributes an additional oxidative burden, resulting from digestion of the host hemoglobin as the parasite grows within the infected cell. This study evaluated the efficacy of Adansonia digitata stem bark extract on hematological and renal changes in established Plasmodium berghei infection in mice. Albino wistar mice were used in the study. The mice were transfected intraperitonially with an inoculum size of l × 107 of chloroquine susceptible strain of Plasmodium berghei-infected erythrocytes. Percentage chemosupression and packed cell volume (PCV) were determined. The antiplasmodium effects of the extracts were investigated by measuring the hemoglobin (Hb) content, white blood cell (WBC) count, and cell differentials. Severity of malaria was determined by measuring the serum creatinine, urea, and uric acid concentrations. An essential biomarker of malaria-associated disturbance in mineral homeostasis was determined by measuring the electrolyte concentrations. Administration of the extracts had effect on the growth of Plasmodium berghei parasite in mice. The extracts showed a significant decrease in percentage parasitemia at the two doses and a significant dose-dependent increase in PCV, percentage chemosupression when administered after established infection. There was a significant decrease in hemoglobin content, neutrophil, lymphocyte, and mean corpuscular hemoglobin concentration (MCHC) in the control group following Plasmodium berghei infection. The extract significantly reduced the WBC, platelet, monocyte count, mean corpuscular hemoglobin (MCH), and mean cell volume (MCV). Administration of the extract after established infection significantly reduced the creatinine, Na+, K+, Ca2+, and Cl− concentrations. The concentrations of urea, uric acid, and Mg2+ were significantly higher in control mice. Our study suggests that Adansonia digitata has antimalarial activity and modulates biochemical and hematological changes in established Plasmodium berghei infection.
-
Chemopreventive and remediation effect of Adansonia digitata L. Baobab (Bombacaceae) stem bark extracts in mouse model malaria.
Journal of ethnopharmacology, 2017Co-Authors: Akinwunmi O. Adeoye, Clement O. BewajiAbstract:Abstract Ethnopharmacological relevance Adansonia digitata L . Baobab (Bombacaceae) solvent extracts have been reported to possess medicinal properties and are currently been used traditionally for the treatment of malaria and several other diseases and infection; however few reports exist in literature that provides supportive scientific evidence in favour of its medicinal use. Aim of the study This study investigated the efficacy of Adansonia digitata stem bark extract in offering protection against experimental malaria and also examined its remediation effect when administered after established infection. Materials and methods Weanling albino mice were used in the study. The mice were transfected intraperitonially with an inoculums size of 1× 10 7 of chloroquine susceptible strain of plasmodium berghei infected erythrocytes. Mechanisms of action of the extract were investigated by measuring the degree of tissue peroxidation and tissue antioxidant status. Severity of malaria was determined by measuring the serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and serum and tissue Alkaline phosphatase (ALP) activity. Results There was a significant increase in serum CRP, TNF-α concentrations and serum and tissue ALP activity in the control mice following Plasmodium berghei infection. All the treatment had effect on the growth of Plasmodium berghei parasites in mice. The extracts showed a significant dose dependent increase packed cell volume (PCV), percentage chemosupression/clearance and a significant decrease in percentage parasitemia at the two doses when administered after established infection. Methanolic extract (MEAD) at 400 mg/kg exhibited the highest chemosupressive activity. The extract significantly reduced the degree of tissue peroxidation, increased the level of reduced glutathione (GSH), catalase and superoxide dismutase activity. Administration of the extract after established infection reduced serum CRP and TNF-α concentrations and serum and tissue ALP activity. Conclusion Our study suggests that Adansonia digitata protects against Plasmodium berghei induced-malaria, and that administration of the extract after established infection reduced malaria progression.
Hassan M. Ibrahim - One of the best experts on this subject based on the ideXlab platform.
-
EVALUATION OF ANTITRYPANOSOMAL ACTIVITY OF ETHYL ACETATE EXTRACT OF Adansonia digitata SEED EXTRACT IN T.B. BRUCEI INFECTED ALBINO MICE
2017Co-Authors: Hassan M. Ibrahim, E. O. Ogbadoyi, Kabiru Y. AdamuAbstract:Adansonia digitata, a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Ethyl acetate extract of the seed of Adansonia digitata was investigated for in-vivo antitrypanosomal activity in albino mice infected with Trypanosoma brucei brucei and treated intraperitoneally with the extracts 24 hours post infection, at doses ranging from 50-500mg/kg for 14 days, while the positive control was administered a single dose of 3.5 Mg/kg body weight standard berenil. The parasitaemia in all the mice was monitored for the period of study. Seed extracts at dose of 400mg/kg showed significant antitrypanosomal activity (P
-
Evaluation of antitrypanosomal activity of Adansonia digitata (methanol seed extract) in Albino mice
Journal of Veterinary Advances, 2013Co-Authors: Hassan M. Ibrahim, Ogbadoyi O Emmanuel, Adamu Yusuf Kabiru, Maimuna Umar Bello, Yemisi IllumiAbstract:Adansonia digitata , a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Methanol seed extracts of the seed of Adansonia digitata was investigated for in-vivo anti-trypanosomal activity in albino mice infected with Trypanosoma brucei brucei and treated intraperitoneally with the extracts 24 hours post infection, at doses ranging from 50-500mg/kg for 14 days. The parasitaemia in each mouse was monitored including the control group which were treated with the standard drug; berenil. Seed extracts at dose of 400mg/kg showed significant antitrypanosomal activity (P
-
Invivo Anti Trypanosomal Efficacy of Fractions of Crude Methanolic Seed Extract of Adansonia digitata in Albino Mice
IOSR Journal of Agriculture and Veterinary Science, 2013Co-Authors: Hassan M. IbrahimAbstract:Adansonia digitata, a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Methanol seed extracts of the seed of Adansonia digitata was investigated for in-vivo anti-trypanosomal activity in albino mice infected with Trypanosoma brucei brucei and treated intraperitoneally with the extracts 24 hours post infection, at doses ranging from 50-500mg/kg for 14 days. The parasitaemia in each mouse was monitored including the control group which were treated with the standard drug; Berenil R. Seed extracts at dose of 400mg/kg showed significant antitrypanosomal activity (P
-
Original Research Paper EVALUATION OF ANTITRYPANOSOMAL ACTIVITY OF ETHYL ACETATE EXTRACT OF Adansonia digitata SEED EXTRACT IN T.B. BRUCEI INFECTED ALBINO MICE
2012Co-Authors: Hassan M. Ibrahim, Maimuna Umar Bello, E. O. Ogbadoyi, Kabiru Y. Adamu, Ilumi J. YemisiAbstract:Adansonia digitata, a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Ethyl acetate extract of the seed of Adansonia digitata was investigated for in-vivo antitrypanosomal activity in albino mice infected with Trypanosoma brucei brucei and treated intraperitoneally with the extracts 24 hours post infection, at doses ranging from 50500mg/kg for 14 days, while the positive control was administered a single dose of 3.5 Mg/kg body weight standard berenil. The parasitaemia in all the mice was monitored for the period of study. Seed extracts at dose of 400mg/kg showed significant antitrypanosomal activity (P
G. J. Esenowo - One of the best experts on this subject based on the ideXlab platform.
-
Studies on germination of Adansonia digitata seeds
The Journal of Agricultural Science, 1991Co-Authors: G. J. EsenowoAbstract:Dormancy in seeds of Adansonia digitata (L.) can be attributed partly to the testa and partly to the pulp. Several methods, such as wet heat treatment, total or partial seed decoating and scarification of seeds with concentrated acids, herbicides, fungicides and growth regulators, were tested in 1988 and 1989 to break dormancy. The most effective was scarification with HNO3 or H2SO4, which gave 86 and 98% germination, respectively, while total decoating, partial decoating, wet heat treatment and ethrel gave 85, 80, 75 and 70%, respectively. Seeds treated with herbicides and fungicides did not germinate. Inhibition of germination caused by the pulp was overcome by thorough washing of seeds and soaking in water for 3 days.
Akinwunmi O. Adeoye - One of the best experts on this subject based on the ideXlab platform.
-
Activity of Adansonia digitata on biochemical and hematological changes in established Plasmodium berghei -infected mice
Comparative Clinical Pathology, 2019Co-Authors: Akinwunmi O. Adeoye, Clement O. BewajiAbstract:The intra-erythrocytic lifestyle of malaria parasite contributes an additional oxidative burden, resulting from digestion of the host hemoglobin as the parasite grows within the infected cell. This study evaluated the efficacy of Adansonia digitata stem bark extract on hematological and renal changes in established Plasmodium berghei infection in mice. Albino wistar mice were used in the study. The mice were transfected intraperitonially with an inoculum size of l × 107 of chloroquine susceptible strain of Plasmodium berghei-infected erythrocytes. Percentage chemosupression and packed cell volume (PCV) were determined. The antiplasmodium effects of the extracts were investigated by measuring the hemoglobin (Hb) content, white blood cell (WBC) count, and cell differentials. Severity of malaria was determined by measuring the serum creatinine, urea, and uric acid concentrations. An essential biomarker of malaria-associated disturbance in mineral homeostasis was determined by measuring the electrolyte concentrations. Administration of the extracts had effect on the growth of Plasmodium berghei parasite in mice. The extracts showed a significant decrease in percentage parasitemia at the two doses and a significant dose-dependent increase in PCV, percentage chemosupression when administered after established infection. There was a significant decrease in hemoglobin content, neutrophil, lymphocyte, and mean corpuscular hemoglobin concentration (MCHC) in the control group following Plasmodium berghei infection. The extract significantly reduced the WBC, platelet, monocyte count, mean corpuscular hemoglobin (MCH), and mean cell volume (MCV). Administration of the extract after established infection significantly reduced the creatinine, Na+, K+, Ca2+, and Cl− concentrations. The concentrations of urea, uric acid, and Mg2+ were significantly higher in control mice. Our study suggests that Adansonia digitata has antimalarial activity and modulates biochemical and hematological changes in established Plasmodium berghei infection.
-
Chemopreventive and remediation effect of Adansonia digitata L. Baobab (Bombacaceae) stem bark extracts in mouse model malaria.
Journal of ethnopharmacology, 2017Co-Authors: Akinwunmi O. Adeoye, Clement O. BewajiAbstract:Abstract Ethnopharmacological relevance Adansonia digitata L . Baobab (Bombacaceae) solvent extracts have been reported to possess medicinal properties and are currently been used traditionally for the treatment of malaria and several other diseases and infection; however few reports exist in literature that provides supportive scientific evidence in favour of its medicinal use. Aim of the study This study investigated the efficacy of Adansonia digitata stem bark extract in offering protection against experimental malaria and also examined its remediation effect when administered after established infection. Materials and methods Weanling albino mice were used in the study. The mice were transfected intraperitonially with an inoculums size of 1× 10 7 of chloroquine susceptible strain of plasmodium berghei infected erythrocytes. Mechanisms of action of the extract were investigated by measuring the degree of tissue peroxidation and tissue antioxidant status. Severity of malaria was determined by measuring the serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and serum and tissue Alkaline phosphatase (ALP) activity. Results There was a significant increase in serum CRP, TNF-α concentrations and serum and tissue ALP activity in the control mice following Plasmodium berghei infection. All the treatment had effect on the growth of Plasmodium berghei parasites in mice. The extracts showed a significant dose dependent increase packed cell volume (PCV), percentage chemosupression/clearance and a significant decrease in percentage parasitemia at the two doses when administered after established infection. Methanolic extract (MEAD) at 400 mg/kg exhibited the highest chemosupressive activity. The extract significantly reduced the degree of tissue peroxidation, increased the level of reduced glutathione (GSH), catalase and superoxide dismutase activity. Administration of the extract after established infection reduced serum CRP and TNF-α concentrations and serum and tissue ALP activity. Conclusion Our study suggests that Adansonia digitata protects against Plasmodium berghei induced-malaria, and that administration of the extract after established infection reduced malaria progression.
