The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform

Anoj Kumar Baliarsinha - One of the best experts on this subject based on the ideXlab platform.

  • Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
    Indian Journal of Endocrinology and Metabolism, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

  • Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation
    Wolters Kluwer Medknow Publications, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis

Je Tooke - One of the best experts on this subject based on the ideXlab platform.

  • edema in patients with Addisons Disease on replacement therapy glucocorticoid excess and mineralocorticoid deficiency
    QJM: An International Journal of Medicine, 1994
    Co-Authors: Ac Shore, De Sandeman, D Mawson, M Donohoe, Je Tooke
    Abstract:

    Steroid hormones influence mechanisms related to oedema formation, including postural vasoconstriction and vascular tone. We studied fifteen patients (7 male, 8 female) with primary adrenal failure on clinically optimal replacement therapy. Five patients, all female, had clinically detectable oedema. Patients with oedema had evidence of mineralocorticoid deficiency, with increased supine and erect plasma renin activity and greater postural fall in blood pressure. Mean morning plasma cortisol levels were significantly higher in the group with oedema, suggesting they were receiving insufficient mineralocorticoid and a possible relative excess of glucocorticoid. There were no significant differences between patients with and without oedema in lower-limb cutaneous blood flow or in postural vasoconstricter responses measured by laser Doppler flowmetry. The mechanism of oedema formation is unclear, but appears not to be modulated by haemodynamic mechanisms with expansion of intravascular volume or, in contrast to the known effects of sex hormones, by impairment of postural vasoconstriction. Theoretically, excess glucocorticoid replacement may result in oedema formation, by direct action on vascular tone, by altering capillary permeability, or by influencing other factors such as atrial natiuretic peptide. Measurement of plasma renin activity in conjunction with plasma cortisol profiles may be useful in adjusting replacement therapy in patients with Addison's Disease and oedema.

Ritesh Kumar Agrawala - One of the best experts on this subject based on the ideXlab platform.

  • Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
    Indian Journal of Endocrinology and Metabolism, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

  • Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation
    Wolters Kluwer Medknow Publications, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis

Arun Kumar Choudhury - One of the best experts on this subject based on the ideXlab platform.

  • Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
    Indian Journal of Endocrinology and Metabolism, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

  • Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation
    Wolters Kluwer Medknow Publications, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis

Binoy Kumar Mohanty - One of the best experts on this subject based on the ideXlab platform.

  • Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
    Indian Journal of Endocrinology and Metabolism, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

  • Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation
    Wolters Kluwer Medknow Publications, 2013
    Co-Authors: Ritesh Kumar Agrawala, Srikanta Kumar Sahoo, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha
    Abstract:

    A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons Disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis