The Experts below are selected from a list of 141564 Experts worldwide ranked by ideXlab platform

Hwa Sup Shin - One of the best experts on this subject based on the ideXlab platform.

  • a novel anti ischemic atp sensitive potassium channel katp opener without vasorelaxation n 6 aminobenzopyranyl n benzyl n cyanoguanidine analogue
    Journal of Medicinal Chemistry, 2001
    Co-Authors: Kyu Yang Yi, Hwa Sup Shin
    Abstract:

    This paper describes the design, synthesis, and biological evaluation of a novel anti-ischemic Compound, (2S,3S,4R)-N-(6-amino-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-benzopyranyl)-N‘-benzyl-N‘‘-cyanoguanidine (33), and the structure−activity relationships leading to the discovery of this Compound. Compound 33 significantly reduced the myocardial infarct zone to area at risk (IZ/AAR) in the ischemic myocardium rat model with high cardioselectivity. Since the cardioprotective effect of Compound 33 is reversed by ATP-sensitive potassium channel (KATP) blockers, its anti-ischemic effect appears to be at least mediated by KATP opening. In Addition, Compound 33 shows good protective activity on neuronal cells against oxidative stress, and therefore it is suggested that Compound 33 may have therapeutic potential both in cardio- and in neuroprotection.

  • a novel anti ischemic atp sensitive potassium channel k atp opener without vasorelaxation n 6 aminobenzopyranyl n benzyl n cyanoguanidine analogue
    Journal of Medicinal Chemistry, 2001
    Co-Authors: Sungeun Yoo, Sunkyung Lee, Jeehee Suh, Nakjeong Kim, Byung Ho Lee, Ho Won Seo, Sunok Kim, Dong Ha Lee, Hong Lim, Hwa Sup Shin
    Abstract:

    This paper describes the design, synthesis, and biological evaluation of a novel anti-ischemic Compound, (2S,3S,4R)-N-(6-amino-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-benzopyranyl)-N'-benzyl-N"-cyanoguanidine (33), and the structure-activity relationships leading to the discovery of this Compound. Compound 33 significantly reduced the myocardial infarct zone to area at risk (IZ/AAR) in the ischemic myocardium rat model with high cardioselectivity. Since the cardioprotective effect of Compound 33 is reversed by ATP-sensitive potassium channel (K(ATP)) blockers, its anti-ischemic effect appears to be at least mediated by K(ATP) opening. In Addition, Compound 33 shows good protective activity on neuronal cells against oxidative stress, and therefore it is suggested that Compound 33 may have therapeutic potential both in cardio- and in neuroprotection.

Jian Zhang - One of the best experts on this subject based on the ideXlab platform.

  • ervadivamines a and b two unusual trimeric monoterpenoid indole alkaloids from ervatamia divaricata
    Journal of Organic Chemistry, 2018
    Co-Authors: Zhi-wen Liu, Jian Zhang, Ming-qun Liu, Xiao-jun Huang, Chun-lin Fan, Dong-mei Zhang, Qing-wen Zhang, Xiaoqi Zhang
    Abstract:

    Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In Addition, Compound 1 exhibited significant cytotoxicity against four cancer cells.

  • Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata
    2018
    Co-Authors: Zhi-wen Liu, Jian Zhang, Ming-qun Liu, Xiao-jun Huang, Chun-lin Fan, Dong-mei Zhang, Qing-wen Zhang
    Abstract:

    Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In Addition, Compound 1 exhibited significant cytotoxicity against four cancer cells

Xiaoqi Zhang - One of the best experts on this subject based on the ideXlab platform.

  • ervadivamines a and b two unusual trimeric monoterpenoid indole alkaloids from ervatamia divaricata
    Journal of Organic Chemistry, 2018
    Co-Authors: Zhi-wen Liu, Jian Zhang, Ming-qun Liu, Xiao-jun Huang, Chun-lin Fan, Dong-mei Zhang, Qing-wen Zhang, Xiaoqi Zhang
    Abstract:

    Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In Addition, Compound 1 exhibited significant cytotoxicity against four cancer cells.

Sungeun Yoo - One of the best experts on this subject based on the ideXlab platform.

  • a novel anti ischemic atp sensitive potassium channel k atp opener without vasorelaxation n 6 aminobenzopyranyl n benzyl n cyanoguanidine analogue
    Journal of Medicinal Chemistry, 2001
    Co-Authors: Sungeun Yoo, Sunkyung Lee, Jeehee Suh, Nakjeong Kim, Byung Ho Lee, Ho Won Seo, Sunok Kim, Dong Ha Lee, Hong Lim, Hwa Sup Shin
    Abstract:

    This paper describes the design, synthesis, and biological evaluation of a novel anti-ischemic Compound, (2S,3S,4R)-N-(6-amino-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-benzopyranyl)-N'-benzyl-N"-cyanoguanidine (33), and the structure-activity relationships leading to the discovery of this Compound. Compound 33 significantly reduced the myocardial infarct zone to area at risk (IZ/AAR) in the ischemic myocardium rat model with high cardioselectivity. Since the cardioprotective effect of Compound 33 is reversed by ATP-sensitive potassium channel (K(ATP)) blockers, its anti-ischemic effect appears to be at least mediated by K(ATP) opening. In Addition, Compound 33 shows good protective activity on neuronal cells against oxidative stress, and therefore it is suggested that Compound 33 may have therapeutic potential both in cardio- and in neuroprotection.

Zhi-wen Liu - One of the best experts on this subject based on the ideXlab platform.

  • ervadivamines a and b two unusual trimeric monoterpenoid indole alkaloids from ervatamia divaricata
    Journal of Organic Chemistry, 2018
    Co-Authors: Zhi-wen Liu, Jian Zhang, Ming-qun Liu, Xiao-jun Huang, Chun-lin Fan, Dong-mei Zhang, Qing-wen Zhang, Xiaoqi Zhang
    Abstract:

    Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In Addition, Compound 1 exhibited significant cytotoxicity against four cancer cells.

  • Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata
    2018
    Co-Authors: Zhi-wen Liu, Jian Zhang, Ming-qun Liu, Xiao-jun Huang, Chun-lin Fan, Dong-mei Zhang, Qing-wen Zhang
    Abstract:

    Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In Addition, Compound 1 exhibited significant cytotoxicity against four cancer cells