The Experts below are selected from a list of 2232 Experts worldwide ranked by ideXlab platform
Nicole A Massoll - One of the best experts on this subject based on the ideXlab platform.
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a ...
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2005Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a uterine-like mass consistent with an extrauterine Adenomyoma presenting 22 years following a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass was pear-shaped with uterine-type smooth muscle and a cavity lined by functional endometrial glands and stroma. To our knowledge, only 4 other cases of an extrauterine uterine-like mass are reported in the literature. Three involved the ovary, while one was located adjacent to the broad ligament with normal pelvic organs. Although none of these other uterus-like masses were described as Adenomyomas with uterine-like features, the histologic findings are strikingly similar. An understanding of the mullerian system suggests that either an embryologic malformation or a differential multipotentiality existing in the subcoelomic tissues in response to ...
Rachel Redman - One of the best experts on this subject based on the ideXlab platform.
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a ...
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2005Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a uterine-like mass consistent with an extrauterine Adenomyoma presenting 22 years following a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass was pear-shaped with uterine-type smooth muscle and a cavity lined by functional endometrial glands and stroma. To our knowledge, only 4 other cases of an extrauterine uterine-like mass are reported in the literature. Three involved the ovary, while one was located adjacent to the broad ligament with normal pelvic organs. Although none of these other uterus-like masses were described as Adenomyomas with uterine-like features, the histologic findings are strikingly similar. An understanding of the mullerian system suggests that either an embryologic malformation or a differential multipotentiality existing in the subcoelomic tissues in response to ...
Edward J Wilkinson - One of the best experts on this subject based on the ideXlab platform.
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a ...
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uterine like mass with features of an extrauterine Adenomyoma presenting 22 years after total abdominal hysterectomy bilateral salpingo oophorectomy a case report and review of the literature
Archives of Pathology & Laboratory Medicine, 2005Co-Authors: Rachel Redman, Edward J Wilkinson, Nicole A MassollAbstract:Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine Adenomyoma is a rare entity. We report a uterine-like mass consistent with an extrauterine Adenomyoma presenting 22 years following a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass was pear-shaped with uterine-type smooth muscle and a cavity lined by functional endometrial glands and stroma. To our knowledge, only 4 other cases of an extrauterine uterine-like mass are reported in the literature. Three involved the ovary, while one was located adjacent to the broad ligament with normal pelvic organs. Although none of these other uterus-like masses were described as Adenomyomas with uterine-like features, the histologic findings are strikingly similar. An understanding of the mullerian system suggests that either an embryologic malformation or a differential multipotentiality existing in the subcoelomic tissues in response to ...
Fulvio Zullo - One of the best experts on this subject based on the ideXlab platform.
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management of women with atypical polypoid Adenomyoma of the uterus a quantitative systematic review
Acta Obstetricia et Gynecologica Scandinavica, 2019Co-Authors: Antonio Raffone, Antonio Travaglino, Gabriele Saccone, Carlo Alviggi, Massimo Mascolo, Giuseppe De Placido, Luigi Insabato, Antonio Mollo, Fulvio ZulloAbstract:INTRODUCTION Atypical polypoid Adenomyoma is an uncommon uterine lesion which can coexist with endometrial atypical hyperplasia and/or cancer. Atypical polypoid Adenomyoma affects premenopausal women in most cases, but it shows high recurrence rate if conservatively treated. To date, the management of patients is based on low-quality evidence and is not standardized. Our primary aim was to explore the optimal management of atypical polypoid Adenomyoma, with particular regard to the fertility-sparing approach. The secondary aim was to define clinicopathologic features of atypical polypoid Adenomyoma. MATERIAL AND METHODS Medline, Embase, Web of Sciences, Scopus, ClinicalTrial.gov, OVID, Google Scholar and Cochrane Library were searched for studies reporting outcomes of atypical polypoid Adenomyoma treatments. Univariate comparisons among outcomes of fertility-sparing treatments (rates of initial response, progression, recurrence, final complete response, pregnancy) were performed with Fisher's exact test (α = .05). RESULTS Eleven retrospective studies with 237 patients were included; 85.5% of patients were premenopausal and 62.9% were nulliparous. Atypical polypoid Adenomyoma coexisted with atypical hyperplasia in 5.5% of cases and with endometrial cancer in 5.9%. Overall risks of recurrence and progression to cancer were 28.9% and 16.6%, respectively. Fertility-sparing treatments included hormonal therapy with or without maintenance, hysteroscopic transcervical resection, dilation and curettage, and hormonal therapy combined with transcervical resection or dilation and curettage. Transcervical resection showed significantly higher initial response rates (P from <0.001 to 0.023) than any other treatment. Transcervical resection and transcervical resection+hormonal therapy showed significantly lower progression rates (P < 0.001), and higher final complete response rates (P < 0.001) than any other treatment. No significant differences were found in the rates of pregnancy (P = 0.533 - 0.647) or recurrence (P = 0.052 - 0.475). Among the different transcervical resection techniques, the 4-step transcervical resection showed significantly lower rates of progression (P = 0.002) and recurrence (P = 0.013) than other techniques. Limitations to our results were the retrospective design of the studies and the relatively small sample size, due to the rarity of atypical polypoid Adenomyoma. CONCLUSIONS Based on its effectiveness and safety, transcervical resection may be the first-line fertility-sparing treatment for atypical polypoid Adenomyoma. In particular, 4-step transcervical resection showed the best results. Given the risk of recurrence, progression and coexistent atypical hyperplasia or cancer, follow-up biopsies are advisable. When fertility preservation is not required, hysterectomy might be advisable.
Antonio Raffone - One of the best experts on this subject based on the ideXlab platform.
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management of women with atypical polypoid Adenomyoma of the uterus a quantitative systematic review
Acta Obstetricia et Gynecologica Scandinavica, 2019Co-Authors: Antonio Raffone, Antonio Travaglino, Gabriele Saccone, Carlo Alviggi, Massimo Mascolo, Giuseppe De Placido, Luigi Insabato, Antonio Mollo, Fulvio ZulloAbstract:INTRODUCTION Atypical polypoid Adenomyoma is an uncommon uterine lesion which can coexist with endometrial atypical hyperplasia and/or cancer. Atypical polypoid Adenomyoma affects premenopausal women in most cases, but it shows high recurrence rate if conservatively treated. To date, the management of patients is based on low-quality evidence and is not standardized. Our primary aim was to explore the optimal management of atypical polypoid Adenomyoma, with particular regard to the fertility-sparing approach. The secondary aim was to define clinicopathologic features of atypical polypoid Adenomyoma. MATERIAL AND METHODS Medline, Embase, Web of Sciences, Scopus, ClinicalTrial.gov, OVID, Google Scholar and Cochrane Library were searched for studies reporting outcomes of atypical polypoid Adenomyoma treatments. Univariate comparisons among outcomes of fertility-sparing treatments (rates of initial response, progression, recurrence, final complete response, pregnancy) were performed with Fisher's exact test (α = .05). RESULTS Eleven retrospective studies with 237 patients were included; 85.5% of patients were premenopausal and 62.9% were nulliparous. Atypical polypoid Adenomyoma coexisted with atypical hyperplasia in 5.5% of cases and with endometrial cancer in 5.9%. Overall risks of recurrence and progression to cancer were 28.9% and 16.6%, respectively. Fertility-sparing treatments included hormonal therapy with or without maintenance, hysteroscopic transcervical resection, dilation and curettage, and hormonal therapy combined with transcervical resection or dilation and curettage. Transcervical resection showed significantly higher initial response rates (P from <0.001 to 0.023) than any other treatment. Transcervical resection and transcervical resection+hormonal therapy showed significantly lower progression rates (P < 0.001), and higher final complete response rates (P < 0.001) than any other treatment. No significant differences were found in the rates of pregnancy (P = 0.533 - 0.647) or recurrence (P = 0.052 - 0.475). Among the different transcervical resection techniques, the 4-step transcervical resection showed significantly lower rates of progression (P = 0.002) and recurrence (P = 0.013) than other techniques. Limitations to our results were the retrospective design of the studies and the relatively small sample size, due to the rarity of atypical polypoid Adenomyoma. CONCLUSIONS Based on its effectiveness and safety, transcervical resection may be the first-line fertility-sparing treatment for atypical polypoid Adenomyoma. In particular, 4-step transcervical resection showed the best results. Given the risk of recurrence, progression and coexistent atypical hyperplasia or cancer, follow-up biopsies are advisable. When fertility preservation is not required, hysterectomy might be advisable.
