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Mohammed A. Alsaif - One of the best experts on this subject based on the ideXlab platform.
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2012Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly ( P
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2011Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly (P < 0.05) increased activities of cardiac marker enzymes in serum and decreased activities in the heart, and increased activities of Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase in the heart, and the activity of sodium potassium-dependent Adenosine Triphosphatase decreased in the heart. ISO induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pretreatment with morin (40 mg/kg) daily for a period of 30 days exhibited significant (P < 0.05) effects and altered these biochemical parameters positively compared to the other two doses. Thus, our study shows that morin has a protective role in ISO-induced MI in rats. The observed effects might be due to the free radical-scavenging, antioxidant and membrane-stabilising properties of morin.
Khalid S. Al-numair - One of the best experts on this subject based on the ideXlab platform.
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2012Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly ( P
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2011Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly (P < 0.05) increased activities of cardiac marker enzymes in serum and decreased activities in the heart, and increased activities of Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase in the heart, and the activity of sodium potassium-dependent Adenosine Triphosphatase decreased in the heart. ISO induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pretreatment with morin (40 mg/kg) daily for a period of 30 days exhibited significant (P < 0.05) effects and altered these biochemical parameters positively compared to the other two doses. Thus, our study shows that morin has a protective role in ISO-induced MI in rats. The observed effects might be due to the free radical-scavenging, antioxidant and membrane-stabilising properties of morin.
Govindasamy Chandramohan - One of the best experts on this subject based on the ideXlab platform.
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2012Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly ( P
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Pretreatment with morin, a flavonoid, ameliorates Adenosine Triphosphatases and glycoproteins in isoproterenol-induced myocardial infarction in rats
Journal of Natural Medicines, 2011Co-Authors: Khalid S. Al-numair, Govindasamy Chandramohan, Mohammed A. AlsaifAbstract:The aim of this investigation was to evaluate the preventive role of morin, a flavonoid, on cardiac marker enzymes such as aspartate transaminase, lactate dehydrogenase, creatine kinase and creatine kinase-MB, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with morin (20, 40 and 80 mg/kg) daily for a period of 30 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at an interval of 24 h for 2 days. ISO-induced rats showed significantly (P < 0.05) increased activities of cardiac marker enzymes in serum and decreased activities in the heart, and increased activities of Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase in the heart, and the activity of sodium potassium-dependent Adenosine Triphosphatase decreased in the heart. ISO induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pretreatment with morin (40 mg/kg) daily for a period of 30 days exhibited significant (P < 0.05) effects and altered these biochemical parameters positively compared to the other two doses. Thus, our study shows that morin has a protective role in ISO-induced MI in rats. The observed effects might be due to the free radical-scavenging, antioxidant and membrane-stabilising properties of morin.
Ponnian Stanely Mainzen Prince - One of the best experts on this subject based on the ideXlab platform.
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Preventive effect of S-allylcysteine on membrane-bound enzymes and glycoproteins in normal and isoproterenol-induced cardiac toxicity in male Wistar rats.
Basic & Clinical Pharmacology & Toxicology, 2008Co-Authors: M. Padmanabhan, Murugan Rajadurai, Ponnian Stanely Mainzen PrinceAbstract:This study was aimed to evaluate the preventive role of S-allylcysteine (SAC) on creatine kinase-MB, iron, iron binding capacity, uric acid, total protein, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol-induced myocardial infarction in rats. Male albino Wistar rats were pre-treated with SAC (50, 100 and 150 mg/kg) daily for a period of 45 days. After the treatment period, isoproterenol (150 mg/kg) was subcutaneously injected in rats at an interval of 24 hr for 2 days. Isoproterenol-induced rats showed significantly (P < 0.05) increased activities of serum creatine kinase-MB and Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase in the heart, and the levels of iron and uric acid in serum and significantly (P < 0.05) decreased the levels of plasma iron binding capacity, plasma total protein, plasma albumin/globulin ratio and activity of sodium potassium-dependent Adenosine Triphosphatase in the heart. Isoproterenol induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pre-treatment with SAC (100 and 150 mg/kg) daily for a period of 45 days exhibited significant (P < 0.05) effect and altered these biochemical parameters positively. SAC (50, 100 and 150 mg/kg) treatment to normal rats did not exhibit any significant effect in any of the parameters studied. Thus, our study shows that SAC has a protective role in isoproterenol-induced myocardial infarction in rats. The observed effects might be due to the free radical scavenging, antioxidant and membrane stabilizing properties of SAC.
M. Padmanabhan - One of the best experts on this subject based on the ideXlab platform.
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Preventive effect of S-allylcysteine on membrane-bound enzymes and glycoproteins in normal and isoproterenol-induced cardiac toxicity in male Wistar rats.
Basic & Clinical Pharmacology & Toxicology, 2008Co-Authors: M. Padmanabhan, Murugan Rajadurai, Ponnian Stanely Mainzen PrinceAbstract:This study was aimed to evaluate the preventive role of S-allylcysteine (SAC) on creatine kinase-MB, iron, iron binding capacity, uric acid, total protein, membrane-bound enzymes such as sodium potassium-dependent Adenosine Triphosphatase, Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase, and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol-induced myocardial infarction in rats. Male albino Wistar rats were pre-treated with SAC (50, 100 and 150 mg/kg) daily for a period of 45 days. After the treatment period, isoproterenol (150 mg/kg) was subcutaneously injected in rats at an interval of 24 hr for 2 days. Isoproterenol-induced rats showed significantly (P < 0.05) increased activities of serum creatine kinase-MB and Calcium-dependent Adenosine Triphosphatase and magnesium-dependent Adenosine Triphosphatase in the heart, and the levels of iron and uric acid in serum and significantly (P < 0.05) decreased the levels of plasma iron binding capacity, plasma total protein, plasma albumin/globulin ratio and activity of sodium potassium-dependent Adenosine Triphosphatase in the heart. Isoproterenol induction also showed a significant increase in the levels of glycoproteins in serum and the heart. Pre-treatment with SAC (100 and 150 mg/kg) daily for a period of 45 days exhibited significant (P < 0.05) effect and altered these biochemical parameters positively. SAC (50, 100 and 150 mg/kg) treatment to normal rats did not exhibit any significant effect in any of the parameters studied. Thus, our study shows that SAC has a protective role in isoproterenol-induced myocardial infarction in rats. The observed effects might be due to the free radical scavenging, antioxidant and membrane stabilizing properties of SAC.