The Experts below are selected from a list of 7239 Experts worldwide ranked by ideXlab platform
Johan Garssen - One of the best experts on this subject based on the ideXlab platform.
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enhanced immunological memory responses to listeria monocytogenes in rodents as measured by delayed type hypersensitivity dth Adoptive Transfer of dth and protective immunity following lactobacillus casei shirota ingestion
Clinical and Vaccine Immunology, 2003Co-Authors: R De Waard, E Claassen, G C A M Bokken, B Buiting, Johan GarssenAbstract:We have investigated the effect of orally administered Lactobacillus casei Shirota (L. casei) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal models in which the animals were rendered immune by a primary Listeria monocytogenes infection. It was shown that orally administered viable L. casei, and not heat-killed L. casei, enhanced significantly the antigen-specific DTH at 24 and 48 h in Wistar rats, Brown Norway rats, and BALB/c mice in a time- and dose-dependent fashion. L. casei had to be administered at least 3 days prior to the DTH assay at a daily dose of 109 CFU in order to induce significant effects. Long-term administration of 109 CFU of viable L. casei resulted in enhanced ACR, as demonstrated by reduced L. monocytogenes counts in the spleen and liver and diminished serum alanine aminoTransferase activity after reinfection. Enhancement of cell-mediated immunological immune responses by L. casei was further established in an Adoptive Transfer Study. Naive recipient BALB/c mice, which were infused with nonadherent, immunized spleen cells from L. casei-fed donor BALB/c mice, showed significantly enhanced DTH responses at 24 and 48 h compared to recipient mice which received spleen cells from control donor mice. In conclusion, orally administered L. casei enhanced cell-mediated immunological memory responses. The effects relied on lactobacillus dose and viability as well as timing of supplementation and, further, appeared to be independent of host species or genetic background.
R De Waard - One of the best experts on this subject based on the ideXlab platform.
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enhanced immunological memory responses to listeria monocytogenes in rodents as measured by delayed type hypersensitivity dth Adoptive Transfer of dth and protective immunity following lactobacillus casei shirota ingestion
Clinical and Vaccine Immunology, 2003Co-Authors: R De Waard, E Claassen, G C A M Bokken, B Buiting, Johan GarssenAbstract:We have investigated the effect of orally administered Lactobacillus casei Shirota (L. casei) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal models in which the animals were rendered immune by a primary Listeria monocytogenes infection. It was shown that orally administered viable L. casei, and not heat-killed L. casei, enhanced significantly the antigen-specific DTH at 24 and 48 h in Wistar rats, Brown Norway rats, and BALB/c mice in a time- and dose-dependent fashion. L. casei had to be administered at least 3 days prior to the DTH assay at a daily dose of 109 CFU in order to induce significant effects. Long-term administration of 109 CFU of viable L. casei resulted in enhanced ACR, as demonstrated by reduced L. monocytogenes counts in the spleen and liver and diminished serum alanine aminoTransferase activity after reinfection. Enhancement of cell-mediated immunological immune responses by L. casei was further established in an Adoptive Transfer Study. Naive recipient BALB/c mice, which were infused with nonadherent, immunized spleen cells from L. casei-fed donor BALB/c mice, showed significantly enhanced DTH responses at 24 and 48 h compared to recipient mice which received spleen cells from control donor mice. In conclusion, orally administered L. casei enhanced cell-mediated immunological memory responses. The effects relied on lactobacillus dose and viability as well as timing of supplementation and, further, appeared to be independent of host species or genetic background.
B Buiting - One of the best experts on this subject based on the ideXlab platform.
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enhanced immunological memory responses to listeria monocytogenes in rodents as measured by delayed type hypersensitivity dth Adoptive Transfer of dth and protective immunity following lactobacillus casei shirota ingestion
Clinical and Vaccine Immunology, 2003Co-Authors: R De Waard, E Claassen, G C A M Bokken, B Buiting, Johan GarssenAbstract:We have investigated the effect of orally administered Lactobacillus casei Shirota (L. casei) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal models in which the animals were rendered immune by a primary Listeria monocytogenes infection. It was shown that orally administered viable L. casei, and not heat-killed L. casei, enhanced significantly the antigen-specific DTH at 24 and 48 h in Wistar rats, Brown Norway rats, and BALB/c mice in a time- and dose-dependent fashion. L. casei had to be administered at least 3 days prior to the DTH assay at a daily dose of 109 CFU in order to induce significant effects. Long-term administration of 109 CFU of viable L. casei resulted in enhanced ACR, as demonstrated by reduced L. monocytogenes counts in the spleen and liver and diminished serum alanine aminoTransferase activity after reinfection. Enhancement of cell-mediated immunological immune responses by L. casei was further established in an Adoptive Transfer Study. Naive recipient BALB/c mice, which were infused with nonadherent, immunized spleen cells from L. casei-fed donor BALB/c mice, showed significantly enhanced DTH responses at 24 and 48 h compared to recipient mice which received spleen cells from control donor mice. In conclusion, orally administered L. casei enhanced cell-mediated immunological memory responses. The effects relied on lactobacillus dose and viability as well as timing of supplementation and, further, appeared to be independent of host species or genetic background.
G C A M Bokken - One of the best experts on this subject based on the ideXlab platform.
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enhanced immunological memory responses to listeria monocytogenes in rodents as measured by delayed type hypersensitivity dth Adoptive Transfer of dth and protective immunity following lactobacillus casei shirota ingestion
Clinical and Vaccine Immunology, 2003Co-Authors: R De Waard, E Claassen, G C A M Bokken, B Buiting, Johan GarssenAbstract:We have investigated the effect of orally administered Lactobacillus casei Shirota (L. casei) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal models in which the animals were rendered immune by a primary Listeria monocytogenes infection. It was shown that orally administered viable L. casei, and not heat-killed L. casei, enhanced significantly the antigen-specific DTH at 24 and 48 h in Wistar rats, Brown Norway rats, and BALB/c mice in a time- and dose-dependent fashion. L. casei had to be administered at least 3 days prior to the DTH assay at a daily dose of 109 CFU in order to induce significant effects. Long-term administration of 109 CFU of viable L. casei resulted in enhanced ACR, as demonstrated by reduced L. monocytogenes counts in the spleen and liver and diminished serum alanine aminoTransferase activity after reinfection. Enhancement of cell-mediated immunological immune responses by L. casei was further established in an Adoptive Transfer Study. Naive recipient BALB/c mice, which were infused with nonadherent, immunized spleen cells from L. casei-fed donor BALB/c mice, showed significantly enhanced DTH responses at 24 and 48 h compared to recipient mice which received spleen cells from control donor mice. In conclusion, orally administered L. casei enhanced cell-mediated immunological memory responses. The effects relied on lactobacillus dose and viability as well as timing of supplementation and, further, appeared to be independent of host species or genetic background.
E Claassen - One of the best experts on this subject based on the ideXlab platform.
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enhanced immunological memory responses to listeria monocytogenes in rodents as measured by delayed type hypersensitivity dth Adoptive Transfer of dth and protective immunity following lactobacillus casei shirota ingestion
Clinical and Vaccine Immunology, 2003Co-Authors: R De Waard, E Claassen, G C A M Bokken, B Buiting, Johan GarssenAbstract:We have investigated the effect of orally administered Lactobacillus casei Shirota (L. casei) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal models in which the animals were rendered immune by a primary Listeria monocytogenes infection. It was shown that orally administered viable L. casei, and not heat-killed L. casei, enhanced significantly the antigen-specific DTH at 24 and 48 h in Wistar rats, Brown Norway rats, and BALB/c mice in a time- and dose-dependent fashion. L. casei had to be administered at least 3 days prior to the DTH assay at a daily dose of 109 CFU in order to induce significant effects. Long-term administration of 109 CFU of viable L. casei resulted in enhanced ACR, as demonstrated by reduced L. monocytogenes counts in the spleen and liver and diminished serum alanine aminoTransferase activity after reinfection. Enhancement of cell-mediated immunological immune responses by L. casei was further established in an Adoptive Transfer Study. Naive recipient BALB/c mice, which were infused with nonadherent, immunized spleen cells from L. casei-fed donor BALB/c mice, showed significantly enhanced DTH responses at 24 and 48 h compared to recipient mice which received spleen cells from control donor mice. In conclusion, orally administered L. casei enhanced cell-mediated immunological memory responses. The effects relied on lactobacillus dose and viability as well as timing of supplementation and, further, appeared to be independent of host species or genetic background.