The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform

Jeffrey Schwartz - One of the best experts on this subject based on the ideXlab platform.

  • Maturation of cortisol responses to Adrenocorticotropic Hormone in twin fetal sheep in vivo.
    American journal of obstetrics and gynecology, 1999
    Co-Authors: William A. Block, James C. Rose, Michael L. Draper, Jeffrey Schwartz
    Abstract:

    Abstract Objective: Adrenal steroidogenesis is important for maturation of fetal organ systems and plays a role in triggering parturition in ovine pregnancies. Studies have suggested a differential increase in baseline cortisol between twin gestations near term. Our aim was to further delineate the mechanisms responsible for the differences between the hypothalamic-pituitary-adrenal axes of twin fetuses in vivo. Study Design: Surgery was performed on pregnant ewes (n = 6) with twin gestations to implant fetal vascular catheters. After recovery but while the subjects were resting, plasma cortisol concentrations were similar in both fetuses. Fetuses received, intravenously, boluses of Adrenocorticotropic Hormone at 2 doses, and plasma samples were obtained for analysis of the cortisol response. This stimulation by Adrenocorticotropic Hormone was then repeated in the same fetuses approximately 4 days later, after the increase of resting daily cortisol values in one but not the other fetus. Results: Cortisol responses to Adrenocorticotropic Hormone before changes in daily resting cortisol concentrations were indistinguishable between twins. However, after separation of daily resting cortisol values, fetuses in group A (elevated resting cortisol concentration) demonstrated a significantly increased response to stimulation by Adrenocorticotropic Hormone. Conclusion: These results suggest a differential development in response to stimulation by Adrenocorticotropic Hormone between twin fetuses in vivo as the mechanism responsible for the asynchronous elevation of one twin's resting plasma cortisol concentration. (Am J Obstet Gynecol 1999;181:498-502.)

William A. Block - One of the best experts on this subject based on the ideXlab platform.

  • Maturation of cortisol responses to Adrenocorticotropic Hormone in twin fetal sheep in vivo.
    American journal of obstetrics and gynecology, 1999
    Co-Authors: William A. Block, James C. Rose, Michael L. Draper, Jeffrey Schwartz
    Abstract:

    Abstract Objective: Adrenal steroidogenesis is important for maturation of fetal organ systems and plays a role in triggering parturition in ovine pregnancies. Studies have suggested a differential increase in baseline cortisol between twin gestations near term. Our aim was to further delineate the mechanisms responsible for the differences between the hypothalamic-pituitary-adrenal axes of twin fetuses in vivo. Study Design: Surgery was performed on pregnant ewes (n = 6) with twin gestations to implant fetal vascular catheters. After recovery but while the subjects were resting, plasma cortisol concentrations were similar in both fetuses. Fetuses received, intravenously, boluses of Adrenocorticotropic Hormone at 2 doses, and plasma samples were obtained for analysis of the cortisol response. This stimulation by Adrenocorticotropic Hormone was then repeated in the same fetuses approximately 4 days later, after the increase of resting daily cortisol values in one but not the other fetus. Results: Cortisol responses to Adrenocorticotropic Hormone before changes in daily resting cortisol concentrations were indistinguishable between twins. However, after separation of daily resting cortisol values, fetuses in group A (elevated resting cortisol concentration) demonstrated a significantly increased response to stimulation by Adrenocorticotropic Hormone. Conclusion: These results suggest a differential development in response to stimulation by Adrenocorticotropic Hormone between twin fetuses in vivo as the mechanism responsible for the asynchronous elevation of one twin's resting plasma cortisol concentration. (Am J Obstet Gynecol 1999;181:498-502.)

Seiichi Hirota - One of the best experts on this subject based on the ideXlab platform.

  • Ectopic Adrenocorticotropic Hormone syndrome associated with olfactory neuroblastoma: acquirement of Adrenocorticotropic Hormone expression during disease course as shown by serial immunohistochemistry examinations.
    The Journal of international medical research, 2018
    Co-Authors: Manabu Kadoya, Seiichi Hirota, Masafumi Kurajoh, Akio Miyoshi, Takuhito Shoji, Tomonori Terada, Yuji Nakamoto, Yoshitane Tsukamoto, Yuji Moriwaki, Hidenori Koyama
    Abstract:

    Ectopic Adrenocorticotropic Hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) is a rare ...

  • Pancreatic solitary fibrous tumor causing ectopic Adrenocorticotropic Hormone syndrome.
    Molecular and cellular endocrinology, 2016
    Co-Authors: Keigo Murakami, Yasuhiro Nakamura, Saulo J.a. Felizola, Ryo Morimoto, Fumitoshi Satoh, Kentaro Takanami, Hideki Katakami, Seiichi Hirota, Yoshiyu Takeda, Makiko Meguro-horike
    Abstract:

    Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II. We report the first case of pancreatic solitary fibrous tumor causing ectopic Adrenocorticotropic Hormone syndrome. An 82-year-old Japanese man presented with lower limb edema, uncontrolled hypertension, hypokalemia, and baseline hypercortisolism. Distal pancreatectomy was performed after the clinical diagnosis of a neuroendocrine tumor with ectopic secretion of Adrenocorticotropic Hormone. On histological examination, the tumor showed spindle cells in a fascicular arrangement. The diagnosis of the solitary fibrous tumor was confirmed by the identification of the NAB2-STAT6 fusion gene and positive immuno-histochemical staining for STAT6 and CD34. Using quantitative real-time polymerase chain reaction, mRNA that encoded proopiomelanocortin, precursor of Adrenocorticotropic Hormone, was detected. Proopiomelanocortin production through the demethylation of the promoter region Domain IV was detected. Pancreatic solitary fibrous tumors represent a new cause of ectopic Adrenocorticotropic Hormone syndrome.

Michael L. Draper - One of the best experts on this subject based on the ideXlab platform.

  • Maturation of cortisol responses to Adrenocorticotropic Hormone in twin fetal sheep in vivo.
    American journal of obstetrics and gynecology, 1999
    Co-Authors: William A. Block, James C. Rose, Michael L. Draper, Jeffrey Schwartz
    Abstract:

    Abstract Objective: Adrenal steroidogenesis is important for maturation of fetal organ systems and plays a role in triggering parturition in ovine pregnancies. Studies have suggested a differential increase in baseline cortisol between twin gestations near term. Our aim was to further delineate the mechanisms responsible for the differences between the hypothalamic-pituitary-adrenal axes of twin fetuses in vivo. Study Design: Surgery was performed on pregnant ewes (n = 6) with twin gestations to implant fetal vascular catheters. After recovery but while the subjects were resting, plasma cortisol concentrations were similar in both fetuses. Fetuses received, intravenously, boluses of Adrenocorticotropic Hormone at 2 doses, and plasma samples were obtained for analysis of the cortisol response. This stimulation by Adrenocorticotropic Hormone was then repeated in the same fetuses approximately 4 days later, after the increase of resting daily cortisol values in one but not the other fetus. Results: Cortisol responses to Adrenocorticotropic Hormone before changes in daily resting cortisol concentrations were indistinguishable between twins. However, after separation of daily resting cortisol values, fetuses in group A (elevated resting cortisol concentration) demonstrated a significantly increased response to stimulation by Adrenocorticotropic Hormone. Conclusion: These results suggest a differential development in response to stimulation by Adrenocorticotropic Hormone between twin fetuses in vivo as the mechanism responsible for the asynchronous elevation of one twin's resting plasma cortisol concentration. (Am J Obstet Gynecol 1999;181:498-502.)

James C. Rose - One of the best experts on this subject based on the ideXlab platform.

  • Maturation of cortisol responses to Adrenocorticotropic Hormone in twin fetal sheep in vivo.
    American journal of obstetrics and gynecology, 1999
    Co-Authors: William A. Block, James C. Rose, Michael L. Draper, Jeffrey Schwartz
    Abstract:

    Abstract Objective: Adrenal steroidogenesis is important for maturation of fetal organ systems and plays a role in triggering parturition in ovine pregnancies. Studies have suggested a differential increase in baseline cortisol between twin gestations near term. Our aim was to further delineate the mechanisms responsible for the differences between the hypothalamic-pituitary-adrenal axes of twin fetuses in vivo. Study Design: Surgery was performed on pregnant ewes (n = 6) with twin gestations to implant fetal vascular catheters. After recovery but while the subjects were resting, plasma cortisol concentrations were similar in both fetuses. Fetuses received, intravenously, boluses of Adrenocorticotropic Hormone at 2 doses, and plasma samples were obtained for analysis of the cortisol response. This stimulation by Adrenocorticotropic Hormone was then repeated in the same fetuses approximately 4 days later, after the increase of resting daily cortisol values in one but not the other fetus. Results: Cortisol responses to Adrenocorticotropic Hormone before changes in daily resting cortisol concentrations were indistinguishable between twins. However, after separation of daily resting cortisol values, fetuses in group A (elevated resting cortisol concentration) demonstrated a significantly increased response to stimulation by Adrenocorticotropic Hormone. Conclusion: These results suggest a differential development in response to stimulation by Adrenocorticotropic Hormone between twin fetuses in vivo as the mechanism responsible for the asynchronous elevation of one twin's resting plasma cortisol concentration. (Am J Obstet Gynecol 1999;181:498-502.)