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Adrenomedullin Peptide
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Artur Fedorowski – One of the best experts on this subject based on the ideXlab platform.
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women-A population-based study.
PloS one, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:Background: Low-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population. Methods: A total of 5291 individuals from the prospective Malmo Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine–vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account. Results: Participants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09-1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures. Conclusions Higher circulating levels of MR-pro-ADM predict low-energy fractures among middle-agedmen, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MRpro- ADM may improve prediction of bone fractures. (Less)
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women—A population-based study
, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:BackgroundLow-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population.MethodsA total of 5291 individuals from the prospective Malmö Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine–vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account.ResultsParticipants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09–1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures.ConclusionsHigher circulating levels of MR-pro-ADM predict low-energy fractures among middle-aged-men, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MR-pro-ADM may improve prediction of bone fractures.
Maria Härstedt – One of the best experts on this subject based on the ideXlab platform.
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women-A population-based study.
PloS one, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:Background: Low-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population. Methods: A total of 5291 individuals from the prospective Malmo Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account. Results: Participants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09-1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures. Conclusions Higher circulating levels of MR-pro-ADM predict low-energy fractures among middle-agedmen, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MRpro- ADM may improve prediction of bone fractures. (Less)
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women—A population-based study
, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:BackgroundLow-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population.MethodsA total of 5291 individuals from the prospective Malmö Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account.ResultsParticipants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09–1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures.ConclusionsHigher circulating levels of MR-pro-ADM predict low-energy fractures among middle-aged-men, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MR-pro-ADM may improve prediction of bone fractures.
Fai Tang – One of the best experts on this subject based on the ideXlab platform.
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Adrenomedullin Peptide gene expression of Adrenomedullin its receptors and receptor activity modifying proteins and receptor binding in rat testis actions on testosterone secretion
Biology of Reproduction, 2006Co-Authors: Isabel S S Hwang, O Waisum, Fai TangAbstract:Adrenomedullin (ADM) has been shown to be present in the human and rat male reproductive systems. This study demonstrates the expression of ADM in the rat testis and its effect on the secretion of testosterone. Whole testicular extracts had 5.43 6 0.42 fmol of immunoreactive ADM per milligram of protein and 84 6 8 fg of ADM mRNA per picogram of Actb (b-actin) mRNA. Immunocytochemical studies showed positive ADM immunostaining in the Leydig cells and in the Sertoli cells. Gel filtfiltration chromatographyoftesticularextractsshowedtwopeaks,withthe predominant one eluting at the position of the ADM precursor. Furthermore, the testis was shown to coexpress mRNAs encoding the calcitonin receptor-like receptor and receptor activity modifying protein 1 (Ramp1), Ramp2, and Ramp3. These account for the specific binding of ADM to the testis, which was partially inhibited by human ADM (22–52) and by human calcitonin generelated Peptide (8–37), the ADM and calcitonin gene-related Peptide receptor antagonists, respectively. Administration of ADM to testicular blocks in vitro resulted in a dose-dependent inhibition of hCG-stimulated release of testosterone, which was abolished by the administration of ADM (22–52). Our results suggest a paracrine effect of ADM on testicular steroidogenesis.
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Rapid regulation of Adrenomedullin in metabolically compromised vascular smooth muscle cells.
Journal of hypertension, 1999Co-Authors: Dominic J. Autelitano, Fai Tang, Peter J. LittleAbstract:OBJECTIVE The prepro-Adrenomedullin gene encodes the biologically active Peptide Adrenomedullin, which acts as a potent vasodilator as well as a modulator of vascular smooth muscle cellcell growth. We investigated the question of whether Adrenomedullin is regulated in response to metabolic perturbations in vascular smooth muscle. MATERIALS AND METHODS Acute inhibition of glycolysis, leading to partial depletion of cellular ATP, was produced in cultured rat aortic vascular smooth muscle cells by replacing glucose with 2-deoxdeoxyglucose. Solution hybridization/RNase protection analysis was used to quantitate changes in expression of the prepro-adreno-medullin messenger RNA and a specific radioimmunoassay was used to assess levels of secreted Adrenomedullin. RESULTS Acute incubation of rat aortic vascular smooth muscle cells with 2-deoxdeoxyglucose caused a rapid and sustained induction of low basal levels of Adrenomedullin messenger RNA, which reached twice the control levels by 1 h and four times control levels by 6 h. The induction of Adrenomedullin messenger RNA expression was dependent upon de-novo gene transcription and was reversed by the re-introduction of glucose. Despite the sustained increase in Adrenomedullin messenger RNA, secretion of immunoreactive-Adrenomedullin from vascular smooth muscle cells was reduced by as much as 75% and paralleled the inhibition of radiolabeled amino acid incorporation into protein during glycolytic inhibition; both parameters recovered towards control levels following re-introduction of glucose. CONCLUSIONS The rapid and reversible activation of the Adrenomedullin gene and inhibition of Adrenomedullin Peptide release in response to metabolic inhibition suggest that Adrenomedullin represents a novel localized mechanism that may modulate regional blood flow and vascular smooth muscle cell proliferation in response to perturbations of normal metabolism.
Olle Melander – One of the best experts on this subject based on the ideXlab platform.
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women-A population-based study.
PloS one, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:Background: Low-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population. Methods: A total of 5291 individuals from the prospective Malmo Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account. Results: Participants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09-1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures. Conclusions Higher circulating levels of MR-pro-ADM predict low-energy fractures among middle-agedmen, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MRpro- ADM may improve prediction of bone fractures. (Less)
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women—A population-based study
, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:BackgroundLow-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population.MethodsA total of 5291 individuals from the prospective Malmö Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account.ResultsParticipants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09–1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures.ConclusionsHigher circulating levels of MR-pro-ADM predict low-energy fractures among middle-aged-men, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MR-pro-ADM may improve prediction of bone fractures.
Cecilia Rogmark – One of the best experts on this subject based on the ideXlab platform.
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women-A population-based study.
PloS one, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:Background: Low-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population. Methods: A total of 5291 individuals from the prospective Malmo Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account. Results: Participants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09-1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures. Conclusions Higher circulating levels of MR-pro-ADM predict low-energy fractures among middle-agedmen, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MRpro- ADM may improve prediction of bone fractures. (Less)
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Cardiovascular biomarkers and risk of low-energy fractures among middle-aged men and women—A population-based study
, 2018Co-Authors: Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur FedorowskiAbstract:BackgroundLow-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population.MethodsA total of 5291 individuals from the prospective Malmö Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-Adrenomedullin–Peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-Peptide (MR-proANP), N-terminal pro-brain natriuretic Peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included. The associations between biomarker levels and first incident low-energy fracture were tested in Cox proportional-hazard models, taking potential interactions and traditional risk factors into account.ResultsParticipants were followed for a median time of 21.0 years, during which 1002 subjects (19%) experienced at least one low-energy fracture. Subjects with incident fracture were older, more likely to be women, had lower BMI and higher prevalence of previous fractures. Among biomarkers, there was a significant interaction between gender and MR-pro-ADM on the risk of fracture (p = 0.002). MR-pro-ADM predicted fractures in men only (hazard ratio, 1.23; 95% CI 1.09–1.40; p = 0.001), whereas there was no association among women. Levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP did not predict fractures.ConclusionsHigher circulating levels of MR-pro-ADM predict low-energy fractures among middle-aged-men, whereas levels of MR-pro-ANP, NT-pro-BNP and CT-pro-AVP are not associated with increased fracture risk. Further controlled studies should test the hypothesis whether MR-pro-ADM may improve prediction of bone fractures.