The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Javier P. Gisbert - One of the best experts on this subject based on the ideXlab platform.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

J L Mendoza - One of the best experts on this subject based on the ideXlab platform.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

Jesus Legido - One of the best experts on this subject based on the ideXlab platform.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

Saioa Rubio - One of the best experts on this subject based on the ideXlab platform.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

  • systematic review the Adverse Effects of sodium phosphate enema
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: J L Mendoza, Jesus Legido, Saioa Rubio, Javier P. Gisbert
    Abstract:

    Summary Background Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side Effects. Aim A systematic review of the literature was conducted to identify the most common Adverse Effects of sodium-phosphate enemas and associated risk factors. Methods A systematic search was conducted in Internet (MEDLINE), and the Cochrane Library, from January 1957 to March 2007. Results A total of 761 references were identified initially, and 39 relevant papers were finally selected. The most common therapeutic indications included constipation (63%). Sixty-eight per cent of the patients having Adverse Effects had associated conditions, the most common being gastrointestinal motility disorders, cardiological diseases and renal failure. Virtually, all side Effects were due to water and electrolyte disturbances. Most patients were under 18 years of age (66%) or older than 65 years (25%). A total of 12 deaths were found. Conclusion The main side Effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.

Kenneth A Conklin - One of the best experts on this subject based on the ideXlab platform.

  • reversing mitochondrial dysfunction fatigue and the Adverse Effects of chemotherapy of metastatic disease by molecular replacement therapy
    Clinical & Experimental Metastasis, 2008
    Co-Authors: Garth L Nicolson, Kenneth A Conklin
    Abstract:

    Metastatic cancers are associated with cellular oxidative stress, and during cancer chemotherapy excess drug-induced oxidative stress can limit therapeutic effectiveness and cause a number of side Effects, including fatigue, nausea, vomiting, diarrhea and more serious Adverse Effects, such as cardiomyopathy, peripheral neuropathy, hepatotoxicity and pulmonary fibrosis. We review here the hypothesis that the acute and chronic Adverse Effects of cancer chemotherapy can be reduced by molecular replacement of membrane lipids and enzymatic cofactors, such as coenzyme Q10. By administering nutritional supplements with replacement molecules and antioxidants, oxidative membrane damage and reductions of cofactors in normal tissues can be reversed, protecting and restoring mitochondrial and other cellular functions and reducing chemotherapy Adverse Effects. Recent clinical trials using cancer and non-cancer patients with chronic fatigue have shown the benefit of molecular replacement plus antioxidants in reducing the damage to mitochondrial membranes, restoring mitochondrial electron transport function, reducing fatigue and protecting cellular structures and enzymes from oxidative damage. Molecular replacement and antioxidant administration mitigates the damage to normal tissues, such as cardiac tissue, and reduces the Adverse Effects of cancer therapy without reduction in therapeutic results.

  • molecular replacement for cancer metabolic and mitochondrial dysfunction fatigue and the Adverse Effects of cancer therapy
    Cancer Genomics & Proteomics, 2006
    Co-Authors: Garth L Nicolson, Kenneth A Conklin
    Abstract:

    During cancer treatment drug-induced oxidative stress can limit the effectiveness of therapy and cause a number of side Effects such as fatigue, nausea, vomiting and diarrhea, as well as more serious Adverse Effects including cardiomyopathy, peripheral neuropathy, hepatotoxicity and pulmonary fibrosis. Many of these Adverse Effects are due to oxidative stress-mediated damage to normal tissues. Antioxidant administration and molecular replacement can mitigate the damage to normal tissues and reduce the Adverse Effects of cancer therapy without loss of therapeutic potential. For example, loss of efficiency in the electron transport chain caused by membrane peroxidation and reduction in coenzyme Q10 can occur during cytotoxic therapy. Molecular replacement of membrane lipids and enzymatic cofactors administered as nutritional supplements with antioxidants can prevent oxidative membrane damage and reduction of cofactors in normal tissues, restore mitochondrial and other cellular functions and reduce the Adverse Effects of cancer therapy. Recent clinical trials using cancer and non-cancer patients with chronic fatigue have shown the benefit of Molecular Replacement Therapy plus antioxidants in restoring mitochondrial electron transport function, reducing moderate to severe chronic fatigue and protecting mitochondrial and other cellular structures and enzymes from oxidative or other damage due to cytotoxic therapy.