The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Yunliang Zheng - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous determination of Aflatoxin b1 Aflatoxin B2 mycophenolic acid and sterigmatocystin in grape pomace by uhplc ms ms
World Mycotoxin Journal, 2014Co-Authors: Lianjun Luan, Na Chen, Zheng Han, Xuesong Liu, Yunliang ZhengAbstract:A reliable ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace. The samples were extracted by acetonitrile aqueous solution and further purified using a solid-phase extraction-based homemade clean-up cartridge. Next, the analytes were separated on a reversed-phase C18 column with a mobile phase consisting of water and acetonitrile. The separated compounds were detected with a tandem quadrupole mass spectrometer operating in positive electro-spray ionisation mode using multiple reaction monitoring. The established method was extensively validated by determining linearity (R2≯0.999), recovery (97.5-102.8%) and precision (relative standard deviation ≤7.0%). This method was then used for the simultaneous determination of the four mycotoxins in grape pomace samples.
-
Simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace by UHPLC-MS/MS
World Mycotoxin Journal, 2014Co-Authors: Lianjun Luan, Na Chen, Zheng Han, Xuesong Liu, Yunliang ZhengAbstract:A reliable ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace. The samples were extracted by acetonitrile aqueous solution and further purified using a solid-phase extraction-based homemade clean-up cartridge. Next, the analytes were separated on a reversed-phase C18 column with a mobile phase consisting of water and acetonitrile. The separated compounds were detected with a tandem quadrupole mass spectrometer operating in positive electro-spray ionisation mode using multiple reaction monitoring. The established method was extensively validated by determining linearity (R2≯0.999), recovery (97.5-102.8%) and precision (relative standard deviation ≤7.0%). This method was then used for the simultaneous determination of the four mycotoxins in grape pomace samples.
Gene-hsiang Lee - One of the best experts on this subject based on the ideXlab platform.
-
Organocatalytic Enantioselective Michael–Acetalization–Reduction–Nef Reaction for a One-Pot Entry to the Functionalized Aflatoxin System. Total Synthesis of (−)- DihydroAflatoxin D2 and (−)- and (+)-Microminutinin
Organic letters, 2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol.
-
organocatalytic enantioselective michael acetalization reduction nef reaction for a one pot entry to the functionalized Aflatoxin system total synthesis of dihydroAflatoxin d2 and and microminutinin
Organic Letters, 2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol.
-
Organocatalytic Enantioselective Michael–Acetalization–Reduction–Nef Reaction for a One-Pot Entry to the Functionalized Aflatoxin System. Total Synthesis of (−)- DihydroAflatoxin D2 and (−)- and (+)-Microminutinin
2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol
Yong Rok Lee - One of the best experts on this subject based on the ideXlab platform.
-
formal total synthesis of Aflatoxin B2 utilizing the rhodium carbenoid dipolar cycloaddition
ChemInform, 1996Co-Authors: Michael C. Pirrung, Yong Rok LeeAbstract:A formal total synthesis of (±)-Aflatoxin B2 has been completed using as the key step the rhodium-mediated dipolar cycloaddition of a cyclic rhodium carbenoid to dihydrofuran.
-
Formal total synthesis of (±)-Aflatoxin B2 utilizing the rhodium carbenoid dipolar cycloaddition
Tetrahedron Letters, 1996Co-Authors: Michael C. Pirrung, Yong Rok LeeAbstract:A formal total synthesis of (±)-Aflatoxin B2 has been completed using as the key step the rhodium-mediated dipolar cycloaddition of a cyclic rhodium carbenoid to dihydrofuran.
Lianjun Luan - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous determination of Aflatoxin b1 Aflatoxin B2 mycophenolic acid and sterigmatocystin in grape pomace by uhplc ms ms
World Mycotoxin Journal, 2014Co-Authors: Lianjun Luan, Na Chen, Zheng Han, Xuesong Liu, Yunliang ZhengAbstract:A reliable ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace. The samples were extracted by acetonitrile aqueous solution and further purified using a solid-phase extraction-based homemade clean-up cartridge. Next, the analytes were separated on a reversed-phase C18 column with a mobile phase consisting of water and acetonitrile. The separated compounds were detected with a tandem quadrupole mass spectrometer operating in positive electro-spray ionisation mode using multiple reaction monitoring. The established method was extensively validated by determining linearity (R2≯0.999), recovery (97.5-102.8%) and precision (relative standard deviation ≤7.0%). This method was then used for the simultaneous determination of the four mycotoxins in grape pomace samples.
-
Simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace by UHPLC-MS/MS
World Mycotoxin Journal, 2014Co-Authors: Lianjun Luan, Na Chen, Zheng Han, Xuesong Liu, Yunliang ZhengAbstract:A reliable ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of Aflatoxin B1, Aflatoxin B2, mycophenolic acid and sterigmatocystin in grape pomace. The samples were extracted by acetonitrile aqueous solution and further purified using a solid-phase extraction-based homemade clean-up cartridge. Next, the analytes were separated on a reversed-phase C18 column with a mobile phase consisting of water and acetonitrile. The separated compounds were detected with a tandem quadrupole mass spectrometer operating in positive electro-spray ionisation mode using multiple reaction monitoring. The established method was extensively validated by determining linearity (R2≯0.999), recovery (97.5-102.8%) and precision (relative standard deviation ≤7.0%). This method was then used for the simultaneous determination of the four mycotoxins in grape pomace samples.
Wei-lun Huang - One of the best experts on this subject based on the ideXlab platform.
-
Organocatalytic Enantioselective Michael–Acetalization–Reduction–Nef Reaction for a One-Pot Entry to the Functionalized Aflatoxin System. Total Synthesis of (−)- DihydroAflatoxin D2 and (−)- and (+)-Microminutinin
Organic letters, 2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol.
-
organocatalytic enantioselective michael acetalization reduction nef reaction for a one pot entry to the functionalized Aflatoxin system total synthesis of dihydroAflatoxin d2 and and microminutinin
Organic Letters, 2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol.
-
Organocatalytic Enantioselective Michael–Acetalization–Reduction–Nef Reaction for a One-Pot Entry to the Functionalized Aflatoxin System. Total Synthesis of (−)- DihydroAflatoxin D2 and (−)- and (+)-Microminutinin
2017Co-Authors: Wei-lun Huang, Arun Raja, Bor-cherng Hong, Gene-hsiang LeeAbstract:An efficient method has been developed for the enantioselective synthesis of the Aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael–acetalization–reduction–Nef reactions that proceed with high enantioselectivities (90–99% ee). The one-pot reaction sequence provides a facile entry to the Aflatoxin system, including dihydroAflatoxin D2, which includes a formal total synthesis of Aflatoxin B2. The first total synthesis of (−)- and (+)-microminutinin was also achieved via this protocol
