The Experts below are selected from a list of 75033 Experts worldwide ranked by ideXlab platform

Alison Bradley - One of the best experts on this subject based on the ideXlab platform.

  • upfront surgery versus neoadjuvant therapy for resectable pancreatic cancer systematic review and bayesian network meta analysis
    Scientific Reports, 2019
    Co-Authors: Alison Bradley, Robert Van Der Meer
    Abstract:

    Current treatment recommendations for resectable pancreatic cancer support upfront resection and adjuvant therapy. Randomized controlled trials offering comparison with the emerging neoadjuvant approach are lacking. This review aims to compare both treatment stRategies for resectable pancreatic cancer. PubMed, MEDLINE, Embase, Cochrane Database and Cochrane Databases were searched for studies comparing neoadjuvant and surgery-first with adjuvant therapy for resectable pancreatic cancer. A Bayesian network meta-analysis was conducted using the Markov chain Monte Carlo method. Cochrane Collaboration’s risk of bias, ROBINS-I and GRADE tools were used to assess quality and risk of bias of included trials. 9 studies compared neoadjuvant therapy and surgery-first with adjuvant therapy (n = 22,285). Aggregate Rate (AR) of R0 resection for neoadjuvant therapy was 0.8008 (0.3636–0.9144) versus 0.7515 (0.2026–0.8611) odds ratio (O.R.) 1.27 (95% CI 0.60–1.96). 1-year survival AR for neoadjuvant therapy was 0.7969 (0.6061–0.9500) versus 0.7481 (0.4848–0.8500) O.R. 1.38 (95% CI 0.69–2.96). 2-year survival AR for neoadjuvant therapy was 0.5178 (0.3000–0.5970) versus 0.5131 (0.2727–0.5346) O.R. 1.26 (95% CI 0.94–1.74). 5-year AR survival for neoadjuvant therapy was 0.2069 (0.0323–0.3300) versus 0.1783 (0.0606–0.2300) O.R. 1.19 (95% CI 0.65–1.73). In conclusion neoadjuvant therapy may offer benefit over surgery-first and adjuvant therapy. However, further randomized controlled trials are needed.

Robert Van Der Meer - One of the best experts on this subject based on the ideXlab platform.

  • upfront surgery versus neoadjuvant therapy for resectable pancreatic cancer systematic review and bayesian network meta analysis
    Scientific Reports, 2019
    Co-Authors: Alison Bradley, Robert Van Der Meer
    Abstract:

    Current treatment recommendations for resectable pancreatic cancer support upfront resection and adjuvant therapy. Randomized controlled trials offering comparison with the emerging neoadjuvant approach are lacking. This review aims to compare both treatment stRategies for resectable pancreatic cancer. PubMed, MEDLINE, Embase, Cochrane Database and Cochrane Databases were searched for studies comparing neoadjuvant and surgery-first with adjuvant therapy for resectable pancreatic cancer. A Bayesian network meta-analysis was conducted using the Markov chain Monte Carlo method. Cochrane Collaboration’s risk of bias, ROBINS-I and GRADE tools were used to assess quality and risk of bias of included trials. 9 studies compared neoadjuvant therapy and surgery-first with adjuvant therapy (n = 22,285). Aggregate Rate (AR) of R0 resection for neoadjuvant therapy was 0.8008 (0.3636–0.9144) versus 0.7515 (0.2026–0.8611) odds ratio (O.R.) 1.27 (95% CI 0.60–1.96). 1-year survival AR for neoadjuvant therapy was 0.7969 (0.6061–0.9500) versus 0.7481 (0.4848–0.8500) O.R. 1.38 (95% CI 0.69–2.96). 2-year survival AR for neoadjuvant therapy was 0.5178 (0.3000–0.5970) versus 0.5131 (0.2727–0.5346) O.R. 1.26 (95% CI 0.94–1.74). 5-year AR survival for neoadjuvant therapy was 0.2069 (0.0323–0.3300) versus 0.1783 (0.0606–0.2300) O.R. 1.19 (95% CI 0.65–1.73). In conclusion neoadjuvant therapy may offer benefit over surgery-first and adjuvant therapy. However, further randomized controlled trials are needed.

Ting Wang - One of the best experts on this subject based on the ideXlab platform.

  • Iterative Polar Quantization Based Modulation to Achieve Channel Capacity in Ultra-High-Speed Optical Communication Systems
    2020
    Co-Authors: Member, Ieee Hussam G Batshon, Member, Ieee Ivan B Djordjevic, Ting Wang
    Abstract:

    Abstract: In this paper, we propose a non-uniform coded modulation format based on iterative polar quantization (IPQ) as a scheme to enable achieving channel capacity in ultra-high-speed optical communication systems. The proposed modulation format is coded with structured low-density parity-check (LDPC) codes optimized for Gaussian channels, and in combination with polarization-multiplexing can achieve 800 Gb/s per wavelength Aggregate Rate and beyond utilizing the currently available components operating at 50 Giga Symbols/s. Using coded IPQ we show that we can achieve capacity for SNRs of up to 25dB, and increase the total propagation distance over optical transmission systems by 275 km over coded star-QAM

  • iterative polar quantization based modulation to achieve channel capacity in ultrahigh speed optical communication systems
    IEEE Photonics Journal, 2010
    Co-Authors: Hussam G Batshon, Ivan B Djordjevic, Ting Wang
    Abstract:

    In this paper, we propose a nonuniform coded-modulation format based on iterative polar quantization (IPQ) as a scheme to enable achieving channel capacity in ultrahigh-speed optical communication systems. The proposed modulation format is coded with structured low-density parity-check (LDPC) codes optimized for Gaussian channels and, in combination with polarization-multiplexing, can achieve 800 Gb/s per wavelength Aggregate Rate and beyond utilizing the currently available components operating at 50 GS/s. Using coded IPQ, we show that we can achieve capacity for signal-to-noise ratios (SNRs) of up to 25 dB and increase the total propagation distance over optical transmission systems by 275 km over coded star-quadrature amplitude modulation (QAM).

Hussam G Batshon - One of the best experts on this subject based on the ideXlab platform.

  • iterative polar quantization based modulation to achieve channel capacity in ultrahigh speed optical communication systems
    IEEE Photonics Journal, 2010
    Co-Authors: Hussam G Batshon, Ivan B Djordjevic, Ting Wang
    Abstract:

    In this paper, we propose a nonuniform coded-modulation format based on iterative polar quantization (IPQ) as a scheme to enable achieving channel capacity in ultrahigh-speed optical communication systems. The proposed modulation format is coded with structured low-density parity-check (LDPC) codes optimized for Gaussian channels and, in combination with polarization-multiplexing, can achieve 800 Gb/s per wavelength Aggregate Rate and beyond utilizing the currently available components operating at 50 GS/s. Using coded IPQ, we show that we can achieve capacity for signal-to-noise ratios (SNRs) of up to 25 dB and increase the total propagation distance over optical transmission systems by 275 km over coded star-quadrature amplitude modulation (QAM).

  • beyond 240 gb s per wavelength optical transmission using coded hybrid subcarrier amplitude phase polarization modulation
    IEEE Photonics Technology Letters, 2010
    Co-Authors: Hussam G Batshon, Ivan B Djordjevic
    Abstract:

    In this letter, we propose a low-density parity-check coded hybrid subcarrier/amplitude/phase/polarization (H-SAPP) modulation scheme suitable to achieve a 240-Gb/s single-channel transmission Rate over optical channels. The proposed scheme doubles the Aggregate transmission Rate achievable by eight-quadrature amplitude modulation while providing 2-dB optical signal-to-noise ratio performance improvement at a bit-error-ratio (BER) of 10-6 . Moreover, H-SAPP can increase the Aggregate Rate of the hybrid amplitude/phase/polarization scheme while maintaining the BER performance intact.

Ivan B Djordjevic - One of the best experts on this subject based on the ideXlab platform.

  • iterative polar quantization based modulation to achieve channel capacity in ultrahigh speed optical communication systems
    IEEE Photonics Journal, 2010
    Co-Authors: Hussam G Batshon, Ivan B Djordjevic, Ting Wang
    Abstract:

    In this paper, we propose a nonuniform coded-modulation format based on iterative polar quantization (IPQ) as a scheme to enable achieving channel capacity in ultrahigh-speed optical communication systems. The proposed modulation format is coded with structured low-density parity-check (LDPC) codes optimized for Gaussian channels and, in combination with polarization-multiplexing, can achieve 800 Gb/s per wavelength Aggregate Rate and beyond utilizing the currently available components operating at 50 GS/s. Using coded IPQ, we show that we can achieve capacity for signal-to-noise ratios (SNRs) of up to 25 dB and increase the total propagation distance over optical transmission systems by 275 km over coded star-quadrature amplitude modulation (QAM).

  • beyond 240 gb s per wavelength optical transmission using coded hybrid subcarrier amplitude phase polarization modulation
    IEEE Photonics Technology Letters, 2010
    Co-Authors: Hussam G Batshon, Ivan B Djordjevic
    Abstract:

    In this letter, we propose a low-density parity-check coded hybrid subcarrier/amplitude/phase/polarization (H-SAPP) modulation scheme suitable to achieve a 240-Gb/s single-channel transmission Rate over optical channels. The proposed scheme doubles the Aggregate transmission Rate achievable by eight-quadrature amplitude modulation while providing 2-dB optical signal-to-noise ratio performance improvement at a bit-error-ratio (BER) of 10-6 . Moreover, H-SAPP can increase the Aggregate Rate of the hybrid amplitude/phase/polarization scheme while maintaining the BER performance intact.