The Experts below are selected from a list of 1515 Experts worldwide ranked by ideXlab platform
Moo Ho Won - One of the best experts on this subject based on the ideXlab platform.
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Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during Aging in Dogs
2008Co-Authors: In Koo Hwang, Choong-hyun Lee, Jung Hoon Choi, Yeo Sung Yoon, Ki Yeon Yoo, Yun Lyul Lee, Yuanjie Sun, Sung-oh Huh, Moo Ho WonAbstract:The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged Dogs. in 1-year-old Dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. in addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. in 3-year-old Dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old Dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.
Gary Lynch - One of the best experts on this subject based on the ideXlab platform.
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spatial patterns of mammalian brain Aging distribution of cathepsin d immunoreactive cell bodies and dystrophic dendrites in Aging Dogs resembles that in alzheimer s disease
2003Co-Authors: Elizabeth Head, Carl W Cotman, Gary LynchAbstract:Elevated levels of the lysosomal enzyme cathepsin D are found in the early stages of Alzheimer's disease (AD) and co-occur with intraneuronal tangles. The present study tested whether increases in cathepsin D would emerge during Aging in another mammalian species. Regional brain patterns of cathepsin D immunostaining were compared in Dogs ages 0.35 to 16 years. Accumulations of immunopositive material were evident in neuronal cell bodies in many forebrain sites in middle-age to old Dogs (>/=6 years). Three types could be distinguished: (1) dense aggregates with no particular position within the cell body; (2) crescent-shaped "caps" that occupied one pole of the cell body; and (3) very dense "spikes" that extended from the cell body for variable distances into the apical dendrite; these spikes were found in only a few areas, most notably the subiculum and layer V of neocortex. The spikes appeared between ages 2 and 5 years and increased steadily with age thereafter. Spikes were found in the subiculum in the aged human brain but only infrequently; they were, however, present in large numbers in AD brains. These results established that brain Aging in Dogs is (1) well advanced by middle age, (2) varies markedly across regions, and (3) in at least some of its aspects (dystrophic dendrites) is prominent in areas known to exhibit pathology early in the course of AD. Combined with previous results for rats, these findings indicated that changes in cathepsin D observed in AD, in particular in the temporal lobe, reflect a generalized mammalian pattern of brain Aging.
In Koo Hwang - One of the best experts on this subject based on the ideXlab platform.
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Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during Aging in Dogs
2008Co-Authors: In Koo Hwang, Choong-hyun Lee, Jung Hoon Choi, Yeo Sung Yoon, Ki Yeon Yoo, Yun Lyul Lee, Yuanjie Sun, Sung-oh Huh, Moo Ho WonAbstract:The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged Dogs. in 1-year-old Dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. in addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. in 3-year-old Dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old Dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.
Elizabeth Head - One of the best experts on this subject based on the ideXlab platform.
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spatial patterns of mammalian brain Aging distribution of cathepsin d immunoreactive cell bodies and dystrophic dendrites in Aging Dogs resembles that in alzheimer s disease
2003Co-Authors: Elizabeth Head, Carl W Cotman, Gary LynchAbstract:Elevated levels of the lysosomal enzyme cathepsin D are found in the early stages of Alzheimer's disease (AD) and co-occur with intraneuronal tangles. The present study tested whether increases in cathepsin D would emerge during Aging in another mammalian species. Regional brain patterns of cathepsin D immunostaining were compared in Dogs ages 0.35 to 16 years. Accumulations of immunopositive material were evident in neuronal cell bodies in many forebrain sites in middle-age to old Dogs (>/=6 years). Three types could be distinguished: (1) dense aggregates with no particular position within the cell body; (2) crescent-shaped "caps" that occupied one pole of the cell body; and (3) very dense "spikes" that extended from the cell body for variable distances into the apical dendrite; these spikes were found in only a few areas, most notably the subiculum and layer V of neocortex. The spikes appeared between ages 2 and 5 years and increased steadily with age thereafter. Spikes were found in the subiculum in the aged human brain but only infrequently; they were, however, present in large numbers in AD brains. These results established that brain Aging in Dogs is (1) well advanced by middle age, (2) varies markedly across regions, and (3) in at least some of its aspects (dystrophic dendrites) is prominent in areas known to exhibit pathology early in the course of AD. Combined with previous results for rats, these findings indicated that changes in cathepsin D observed in AD, in particular in the temporal lobe, reflect a generalized mammalian pattern of brain Aging.
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brain Aging in Dogs parallels with human brain Aging and alzheimer s disease
2001Co-Authors: Elizabeth HeadAbstract:Differentiating normal from pathologic Aging is a challenge to veterinarians treating geriatric patients and to clinicians diagnosing Alzheimer's disease. Part of the difficulty stems from the lack of a biological marker. Dogs and humans develop similar cognitive dysfunction with age, and a subset of individuals develop severe impairments. Similar neuropathology also develops in the brains of elderly humans, individuals with Alzheimer's disease, and Dogs. Both species develop senile plaque neuropathology, with more extensive plaque accumulation associated with severe cognitive impairments. This article discusses similarities in the clinical features and development of neuropathology with age in both Dogs and humans and provides a discussion of treatment options.
Choong-hyun Lee - One of the best experts on this subject based on the ideXlab platform.
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Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during Aging in Dogs
2008Co-Authors: In Koo Hwang, Choong-hyun Lee, Jung Hoon Choi, Yeo Sung Yoon, Ki Yeon Yoo, Yun Lyul Lee, Yuanjie Sun, Sung-oh Huh, Moo Ho WonAbstract:The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged Dogs. in 1-year-old Dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. in addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. in 3-year-old Dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old Dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.