The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
C P Panayiotopoulos - One of the best experts on this subject based on the ideXlab platform.
-
posterior Agyria pachygyria with polymicrogyria evidence for an inherited neuronal migration disorder
Neurology, 1995Co-Authors: C D Ferrie, Graeme D Jackson, S Giannakodimos, C P PanayiotopoulosAbstract:Article abstract-We describe two brothers with mental retardation and refractory epilepsy. MRI revealed symmetrical Agyria-pachygyria of the temporo-occipito-parietal regions, areas of deeply infolded polymicrogyric parietal cortex, and dilated occipital horns (colpocephaly). The stereotyped clinical, EEG, and MRI findings suggest that this may be a distinct inherited condition and imply that Agyria-pachygyria with polymicrogyria is not always sporadic. NEUROLOGY 1995;45: 150-153
Jean Aicardi - One of the best experts on this subject based on the ideXlab platform.
-
the Agyria pachygyria complex a spectrum of cortical malformations
Brain & Development, 1991Co-Authors: Jean AicardiAbstract:Agyria-pachygyria is a relatively common brain malformation in humans as shown by the recent experience with CT scan and MR imaging. However, the specificity of imaging is not completely established and it is not known whether all cases with a thick cortical ribbon and a smooth surface correspond histologically to actual Agyria-pachygyria or may belong to different pathological anomalies such as polymicrogyria. The extent, distribution and detailed structure of Agyriapachygyria vary widely and the clinical features are accordingly very diverse. Rather than one entity, pachygyric cortical abnormalities form a broad spectrum that raises different clinical, nosological and genetic problems. Therefore, a precise analysis of each case is necessary to establish the prognosis and risk of recurrence.
C D Ferrie - One of the best experts on this subject based on the ideXlab platform.
-
posterior Agyria pachygyria with polymicrogyria evidence for an inherited neuronal migration disorder
Neurology, 1995Co-Authors: C D Ferrie, Graeme D Jackson, S Giannakodimos, C P PanayiotopoulosAbstract:Article abstract-We describe two brothers with mental retardation and refractory epilepsy. MRI revealed symmetrical Agyria-pachygyria of the temporo-occipito-parietal regions, areas of deeply infolded polymicrogyric parietal cortex, and dilated occipital horns (colpocephaly). The stereotyped clinical, EEG, and MRI findings suggest that this may be a distinct inherited condition and imply that Agyria-pachygyria with polymicrogyria is not always sporadic. NEUROLOGY 1995;45: 150-153
Natalio Fejerman - One of the best experts on this subject based on the ideXlab platform.
-
bilateral posterior Agyria pachygyria and epilepsy
Brain & Development, 2003Co-Authors: Roberto Caraballo, Ricardo Cersosimo, Alberto Espeche, Natalio FejermanAbstract:We analyzed the electroclinical findings in two patients with bilateral posterior Agyria-pachygyria. Both patients presented with mental retardation, mild motor deficit and epilepsy. The electroclinical findings were characterized by frequent tonic or atonic generalized seizures with occasionally simple or complex partial seizures. Interictal electroencephalography (EEG) showed occipital spikes and diffuse polyspike-wave paroxysms predominantly in the posterior region. Ictal EEG showed diffuse 10-11 Hz activity. Cerebral magnetic resonance imagings (MRIs) showed thickened cortex in the parieto-occipital lobes, bilaterally and symmetrically. The volume of underlying white matter appeared reduced, and the overlying subarachnoid spaces were enlarged. The occipital horns were dilated. These findings were compatible with Agyria-pachygyria of the posterior portions of the brain. In conclusion, in patients with mental retardation, mild motor deficit and epilepsy characterized by tonic or atonic generalized seizures, interictal EEG with diffuse polyspike-wave paroxysms predominantly in posterior region, posterior focal epileptilorm abnormalities and ictal diffuse 10-11 Hz activity, bilateral parieto-occipital Agyria-pachygyria should be considered as a possible etiology. Magnetic resonance image is the best neuroradiological study to identify this disorder of cortical development.
-
Bilateral posterior Agyria–pachygyria and epilepsy
Brain & Development, 2003Co-Authors: Roberto Caraballo, Ricardo Cersosimo, Alberto Espeche, Natalio FejermanAbstract:We analyzed the electroclinical findings in two patients with bilateral posterior Agyria-pachygyria. Both patients presented with mental retardation, mild motor deficit and epilepsy. The electroclinical findings were characterized by frequent tonic or atonic generalized seizures with occasionally simple or complex partial seizures. Interictal electroencephalography (EEG) showed occipital spikes and diffuse polyspike-wave paroxysms predominantly in the posterior region. Ictal EEG showed diffuse 10-11 Hz activity. Cerebral magnetic resonance imagings (MRIs) showed thickened cortex in the parieto-occipital lobes, bilaterally and symmetrically. The volume of underlying white matter appeared reduced, and the overlying subarachnoid spaces were enlarged. The occipital horns were dilated. These findings were compatible with Agyria-pachygyria of the posterior portions of the brain. In conclusion, in patients with mental retardation, mild motor deficit and epilepsy characterized by tonic or atonic generalized seizures, interictal EEG with diffuse polyspike-wave paroxysms predominantly in posterior region, posterior focal epileptilorm abnormalities and ictal diffuse 10-11 Hz activity, bilateral parieto-occipital Agyria-pachygyria should be considered as a possible etiology. Magnetic resonance image is the best neuroradiological study to identify this disorder of cortical development.
Graeme D Jackson - One of the best experts on this subject based on the ideXlab platform.
-
posterior Agyria pachygyria with polymicrogyria evidence for an inherited neuronal migration disorder
Neurology, 1995Co-Authors: C D Ferrie, Graeme D Jackson, S Giannakodimos, C P PanayiotopoulosAbstract:Article abstract-We describe two brothers with mental retardation and refractory epilepsy. MRI revealed symmetrical Agyria-pachygyria of the temporo-occipito-parietal regions, areas of deeply infolded polymicrogyric parietal cortex, and dilated occipital horns (colpocephaly). The stereotyped clinical, EEG, and MRI findings suggest that this may be a distinct inherited condition and imply that Agyria-pachygyria with polymicrogyria is not always sporadic. NEUROLOGY 1995;45: 150-153
