The Experts below are selected from a list of 846 Experts worldwide ranked by ideXlab platform
David G Mcleod - One of the best experts on this subject based on the ideXlab platform.
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tolerability of nonsteroidal antiandrogens in the treatment of advanced prostate cancer
Oncologist, 1997Co-Authors: David G McleodAbstract:This review compares the tolerability profiles of the three currently available nonsteroidal antiandrogens, flutamide, bicalutamide and nilutamide. Pharmacological effects associated with blockade of the androgen receptor are frequent with all three drugs. Gynecomastia and breast pain are seen more frequently during antiandrogen monotherapy than during combination with medical or surgical castration or castration alone, and the reverse is true for hot flashes, which are a side effect of castration. Gastrointestinal symptoms are also common to all three drugs, but diarrhea occurs more frequently in flutamide studies than in bicalutamide or nilutamide studies. Hepatotoxicity has been seen with all three antiandrogens, but acute, reversible hepatitis and fatal fulminant hepatitis have also been reported with both nilutamide and flutamide. All three drugs have been associated with asymptomatic elevations in aminotransferases and may reduce hemoglobin levels. Adverse events that have been reported with nilutamide include interstitial pneumonitis, delayed adaptation to darkness after exposure to bright light and Alcohol Intolerance. To date, bicalutamide appears to have some advantage over flutamide and nilutamide in terms of tolerability. The Oncologist 1997;2:18-27
John H Newman - One of the best experts on this subject based on the ideXlab platform.
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Alcohol Intolerance associated with hodgkin lymphoma
Canadian Medical Association Journal, 2013Co-Authors: Andrew J Bryant, John H NewmanAbstract:A 31-year-old man presented to our clinic with severe chest pain that began minutes after ingesting 2–3 sips of Alcohol. This reaction had been occurring for the previous 3 months. The patient felt no pain when swallowing other liquids or solids, and his pain was relieved with low doses (400–600
Jochen Brasch - One of the best experts on this subject based on the ideXlab platform.
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Alcohol: Intolerance syndromes, urticarial and anaphylactoid reactions.
Clinics in Dermatology, 1999Co-Authors: Michael Sticherling, Jochen BraschAbstract:Ethyl Alcohol (called “Alcohol” hereafter) is widely consumed all over the world. Acute and chronic effects of Alcohol as well as Alcohol addiction are well known and present a major problem in public health care.1‐3 Pharmacological and toxicological effects of Alcohol are related to its enzymatic metabolism, aspects that are dealt with elsewhere in this issue of Clinics in Dermatology. At the same time, Alcohol is generated during physiological metabolism in most human cells.4 In humans, up to 0.5 to 0.8 g are produced per day, resulting in a physiological Alcohol blood level of 0.01‐ 0.03‰. Despite gross exogenous and endogenous encounters of this ubiquitous compound, a number of Intolerance syndromes and anaphylactoid reactions are known. Regarding the amount of Alcohol consumed per year, the incidence of such syndromes is low, but symptoms can be unexpected and life-threatening. Especially in differential diagnoses of food allergies and urticarial as well as flushing syndromes, a possible role of Alcohol should be considered. The range of adverse effects is listed in Table 1 and will be presented in more detail in the following sections. Clinical Appearance Among Intolerance syndromes following ethanol intake, flushing syndromes have to be distinguished from urticarial reactions because of their different pathomechanisms and clinical implications. Two major clinical groups of Alcohol-related flushing syndromes can be discriminated.5 In addition to Alcohol, the first type of flushing can be associated with intake of certain drugs and is therefore called drug-Alcohol flushing.5,6 The second group is termed “simple Alcohol flushing” because it is not related to any drug-intake. Simple Alcohol flushing affects 3‐29% of Occidentals, but as it can be found in 47‐ 85% of (predominantly Asian) Orientals it is also referred to as “Oriental flushing.”7,8
Dionisius J. Du Plessis - One of the best experts on this subject based on the ideXlab platform.
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Castration plus nilutamide vs castration plus placebo in advanced prostate cancer. A review.
Urology, 1991Co-Authors: Dionisius J. Du PlessisAbstract:Abstract Combination of antiandrogen treatment with surgical or medical castration shouldimprove the efficacy of endocrine treatment of prostatic cancer by blocking the effects of adrenal androgens. A nonsteroidal antiandrogen, nilutamide, has shown promising results in preliminary open studies. In a short-term (29 days) comparison of nilutamide plus buserelin and buserelin plus placebo, nilutamide (300 mg/day), significantly reduced bone pain, and fewer patients experienced worsening pain than in the control group. The initial buserelin-induced increase in prostatic acid phosphatase was prevented by nilutamide, but there was a similar increase in testosterone and gonadotropin concentrations to that seen in the control group. Thus, nilutamide can prevent the tumor flare-up associated with the start of luteinizing hormone-releasing hormone (LH-RH) treatment, even though the endocrine responses are not affected. In three multicenter, randomized. double-blind placebo-controlled trials of castration and nilutamide involving 248 patients, the comnbination of nilutamide and castration decreased bone pain, improved performance status, and increased the number of patients with objective regression, compared with patients who were castrated but did not receive nilutamide. Nilutamide was generally well tolerated, though visual disorders, gastrointestinal disorders, and Alcohol Intolerance were reported in patients receiving nilutamide. The results suggest that nilutamide improves the efficacy of castration in patients with prostatic cancer. Current studies are investigating the effects of this treatment on survival and the risk-benefit ratio.
Mark S Soloway - One of the best experts on this subject based on the ideXlab platform.
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interstitial pneumonitis associated with neoadjuvant leuprolide and nilutamide for prostate cancer
The Journal of Urology, 1998Co-Authors: Jeff A Wieder, Mark S SolowayAbstract:Nilutamide is a new synthetic nonsteroidal antiandrogen. Most clinical studies of nilutamide have evaluated its efficacy in the treatment of advanced prostate adenocarcinoma as monotherapy, or in combination with orchiectomy or a luteinizing hormone-releasing hormone agonist.1 Adverse reactions associated with nilutamide include gastrointestinal disturbances, problems with light to dark adaptation, Alcohol Intolerance and, rarely, interstitial pneumonitis.1 To our knowledge nilutamide induced interstitial pneumonitis during neoadjuvant hormone therapy has not been reported. We report a case of interstitial pneumonitis after neoadjuvant nilutamide and leuprolide for prostate cancer.