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Alcohol Liver Cirrhosis
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Halina Cichoż-lach – One of the best experts on this subject based on the ideXlab platform.
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Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals
Scandinavian Journal of Gastroenterology, 2007Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Objective. To investigate the effects of ADH and ALDH gene polymorphism on the development of Alcoholism, Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals. Material and methods. We determined the allele and genotype of ADH2, ADH3 and ALDH2 in 198 subjects: 57 with Alcohol Cirrhosis, 44 with Alcohol chronic pancreatitis and 43 “healthy Alcoholics”; 54 healthy non-drinkers served as controls. Genotyping was performed using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method on white cell DNA. Results. In the population examined the ADH2*1 allele frequency was 97.97%.The tests did not show the ADH2*3 allele. The ADH3*1 allele frequency was 57.07%. The ADH2*1 and the ADH3*1 alleles were statistically more common among patients who abuse Alcohol in comparison with the controls. The ADH2*2 allele was not detected in any of the patients with chronic Alcohol pancreatitis. The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantl…
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The influence of genetic polymorphism of CYP2E1 on the development of Alcohol Liver Cirrhosis
Wiadomosci lekarskie (Warsaw Poland : 1960), 2006Co-Authors: Halina Cichoż-lach, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Maria SłomkaAbstract:UNLABELLED Alcoholism is a significant medical, social, and economic problem. Genetic polymorphism of enzymes involved in Alcohol metabolism plays a relevant role in etiopathogenesis of Alcohol disease and Alcohol Liver Cirrhosis. The aim of the study was the evaluation of the influence of genetic polymorphism of CYP2E1 on the development of the Alcohol abuse and Alcohol Liver Cirrhosis the Polish population. MATERIAL AND METHODS The CYP2E1 genotype and c1 and c2 alleles frequency were examined in 188 patients. Genotyping of the CYP2E1 was performed using polymerase chain reaction-restriction fragment length polymorphism method on white cell DNA. RESULTS In the examined population encompassing 188 subjects the c2 allele was present only in 1.06% of patients. It was found only in patients abusing Alcohol. In the group of patients with Alcoholic Cirrhosis it was present in 3.5% of cases. The c1/c2 genotype was present in 2.12% of subjects. The c2/c2 genotype was not found in any patient. Heterozygotes cl/c2 were present only in 7% of patients with Alcohol Liver Cirrhosis. The c2 allele and cl/c2 genotype occurred statistically significantly more frequently in patients with Alcohol Cirrhosis than in control group. Patients possessing the c2 allele and cl/c2 genotype statistically significantly earlier initiated the Alcohol abusing than those in which the c1 allele and c1/c1 genotype were present. CONCLUSION Our studies suggest that the frequency of allele c2 in Polish population is low, but the presence of c2 allele may be a risk factor for the Alcohol Liver Cirrhosis.
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GENETIC POLYMORPHISM OF Alcohol DEHYDROGENASE 3 IN Alcohol Liver Cirrhosis AND IN Alcohol CHRONIC PANCREATITIS
Alcohol and Alcoholism, 2005Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to Alcohol disease of the Liver and chronic Alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR-restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in Alcohol abusers compared with non-drinkers. The examinations of the group of Alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of Alcohol dependence between genders in the Polish population.
Jacek Wojcierowski – One of the best experts on this subject based on the ideXlab platform.
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Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals
Scandinavian Journal of Gastroenterology, 2007Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Objective. To investigate the effects of ADH and ALDH gene polymorphism on the development of Alcoholism, Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals. Material and methods. We determined the allele and genotype of ADH2, ADH3 and ALDH2 in 198 subjects: 57 with Alcohol Cirrhosis, 44 with Alcohol chronic pancreatitis and 43 “healthy Alcoholics”; 54 healthy non-drinkers served as controls. Genotyping was performed using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method on white cell DNA. Results. In the population examined the ADH2*1 allele frequency was 97.97%.The tests did not show the ADH2*3 allele. The ADH3*1 allele frequency was 57.07%. The ADH2*1 and the ADH3*1 alleles were statistically more common among patients who abuse Alcohol in comparison with the controls. The ADH2*2 allele was not detected in any of the patients with chronic Alcohol pancreatitis. The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantl…
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GENETIC POLYMORPHISM OF Alcohol DEHYDROGENASE 3 IN Alcohol Liver Cirrhosis AND IN Alcohol CHRONIC PANCREATITIS
Alcohol and Alcoholism, 2005Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to Alcohol disease of the Liver and chronic Alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR-restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in Alcohol abusers compared with non-drinkers. The examinations of the group of Alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of Alcohol dependence between genders in the Polish population.
Maria Słomka – One of the best experts on this subject based on the ideXlab platform.
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Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals
Scandinavian Journal of Gastroenterology, 2007Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Objective. To investigate the effects of ADH and ALDH gene polymorphism on the development of Alcoholism, Alcohol Liver Cirrhosis and Alcohol chronic pancreatitis among Polish individuals. Material and methods. We determined the allele and genotype of ADH2, ADH3 and ALDH2 in 198 subjects: 57 with Alcohol Cirrhosis, 44 with Alcohol chronic pancreatitis and 43 “healthy Alcoholics”; 54 healthy non-drinkers served as controls. Genotyping was performed using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method on white cell DNA. Results. In the population examined the ADH2*1 allele frequency was 97.97%.The tests did not show the ADH2*3 allele. The ADH3*1 allele frequency was 57.07%. The ADH2*1 and the ADH3*1 alleles were statistically more common among patients who abuse Alcohol in comparison with the controls. The ADH2*2 allele was not detected in any of the patients with chronic Alcohol pancreatitis. The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantl…
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The influence of genetic polymorphism of CYP2E1 on the development of Alcohol Liver Cirrhosis
Wiadomosci lekarskie (Warsaw Poland : 1960), 2006Co-Authors: Halina Cichoż-lach, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Maria SłomkaAbstract:UNLABELLED Alcoholism is a significant medical, social, and economic problem. Genetic polymorphism of enzymes involved in Alcohol metabolism plays a relevant role in etiopathogenesis of Alcohol disease and Alcohol Liver Cirrhosis. The aim of the study was the evaluation of the influence of genetic polymorphism of CYP2E1 on the development of the Alcohol abuse and Alcohol Liver Cirrhosis the Polish population. MATERIAL AND METHODS The CYP2E1 genotype and c1 and c2 alleles frequency were examined in 188 patients. Genotyping of the CYP2E1 was performed using polymerase chain reaction-restriction fragment length polymorphism method on white cell DNA. RESULTS In the examined population encompassing 188 subjects the c2 allele was present only in 1.06% of patients. It was found only in patients abusing Alcohol. In the group of patients with Alcoholic Cirrhosis it was present in 3.5% of cases. The c1/c2 genotype was present in 2.12% of subjects. The c2/c2 genotype was not found in any patient. Heterozygotes cl/c2 were present only in 7% of patients with Alcohol Liver Cirrhosis. The c2 allele and cl/c2 genotype occurred statistically significantly more frequently in patients with Alcohol Cirrhosis than in control group. Patients possessing the c2 allele and cl/c2 genotype statistically significantly earlier initiated the Alcohol abusing than those in which the c1 allele and c1/c1 genotype were present. CONCLUSION Our studies suggest that the frequency of allele c2 in Polish population is low, but the presence of c2 allele may be a risk factor for the Alcohol Liver Cirrhosis.
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GENETIC POLYMORPHISM OF Alcohol DEHYDROGENASE 3 IN Alcohol Liver Cirrhosis AND IN Alcohol CHRONIC PANCREATITIS
Alcohol and Alcoholism, 2005Co-Authors: Halina Cichoż-lach, Maria Słomka, Jadwiga Partycka, Irina Nesina, Krzysztof Celiński, Jacek WojcierowskiAbstract:Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to Alcohol disease of the Liver and chronic Alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR-restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in Alcohol abusers compared with non-drinkers. The examinations of the group of Alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of Alcohol dependence between genders in the Polish population.