The Experts below are selected from a list of 3183 Experts worldwide ranked by ideXlab platform
Giovanni Addolorato - One of the best experts on this subject based on the ideXlab platform.
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Identification and Management of Alcohol Withdrawal Syndrome
Drugs, 2015Co-Authors: Antonio Mirijello, Cristina D’angelo, Gabriele Vassallo, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni AddoloratoAbstract:Symptoms of Alcohol Withdrawal Syndrome (AWS) may develop within 6–24 h after the abrupt discontinuation or decrease of Alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading, fixed-dose or symptom-triggered) may be chosen on the basis of patient characteristics. Severe Withdrawal could require ICU admission and the use of barbiturates or propofol. Other drugs, such as α_2-agonists (clonidine and dexmetedomidine) and β-blockers can be used as adjunctive treatments to control neuroautonomic hyperactivity. Furthermore, neuroleptic agents can help control hallucinations. Finally, other medications for the treatment for AWS have been investigated with promising results. These include carbamazepine, valproate, sodium oxybate, baclofen, gabapentin and topiramate. The usefulness of these agents are discussed.
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Sodium oxybate in the treatment of Alcohol dependence: from the Alcohol Withdrawal Syndrome to the Alcohol relapse prevention
Expert opinion on pharmacotherapy, 2013Co-Authors: Katrin Skala, Antonio Mirijello, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Gabriele A. Vassallo, Henriette Walter, Otto M. Lesch, Giovanni AddoloratoAbstract:Introduction: Sodium oxybate (SMO) has been shown to be safe and effective in the treatment of patients with Alcohol use disorders (AUDs); it was approved in Italy and Austria for the treatment of Alcohol Withdrawal Syndrome and for relapse prevention. The focus of this review is to discuss the clinical evidence on the therapeutic potential of SMO for AUDs. Areas covered: This review covers the studies in patients with Alcohol Withdrawal Syndrome who received SMO for the treatment of Withdrawal symptoms and the studies in patients with AUDs who received SMO to achieve total Alcohol abstinence, reduction of Alcohol intake, and relapse prevention. Relevant medical literature on SMO was identified by searching databases including MEDLINE and EMBASE (searches last updated 20 September 2013), bibliographies from published literature, clinical trial registries/databases, and websites. Expert opinion: SMO has proved safe and effective in the treatment of Alcohol Withdrawal Syndrome and in the prevention of relap...
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rapid suppression of Alcohol Withdrawal Syndrome by baclofen
The American Journal of Medicine, 2002Co-Authors: Giovanni Addolorato, Maria De Bernardi, Fabio Caputo, Esmeralda Capristo, Giancarlo Colombo, Luigi Janiri, Roberta Agabio, Gian Luigi Gessa, Giovanni GasbarriniAbstract:Alcohol Withdrawal Syndrome is a distressing and at times life-threatening condition in Alcohol-dependent patients (1). Usually, symptoms develop within 6 –24 hours after the last drink (2). Early symptoms include raised blood pressure and pulse rate, tremor, hyperreflexia, and anxiety with increased irritability. Clinical management is aimed at symptom relief, prevention of seizures and delirium, and a smooth transition to a treatment program to maintain long-term abstinence from Alcohol (3). Benzodiazepines are presently the drug of choice (4). We recently found that baclofen, a -aminobutyric acid (GABA)B receptor agonist used to control spasticity (5), reduced voluntary Alcohol intake in Alcohol-preferring rats (6), as well as Alcohol craving and intake, up to complete Alcohol abstinence, in Alcohol-dependent patients (7). Furthermore, baclofen suppressed the intensity of Alcohol Withdrawal Syndrome in rats who were physically dependent on Alcohol (6). We therefore studied the effects of oral administration of baclofen in patients with severe Alcohol Withdrawal Syndrome.
Andrew J. Mcbride - One of the best experts on this subject based on the ideXlab platform.
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A COMPARISON OF RATING SCALES FOR THE Alcohol-Withdrawal Syndrome
Alcohol and Alcoholism, 2001Co-Authors: David Williams, Julia Lewis, Andrew J. McbrideAbstract:— This paper reviews the literature on the use of rating scales within the treatment of the Alcohol-Withdrawal Syndrome. A computer-assisted literature search identified trials of therapy for and rating scales used in Alcohol-Withdrawal states. Eighteen rating scales were identified. There is a wide variation in symptom items included in these scales. Scales also vary in their length and ease of application. We conclude that it is important to use validated and reliable assessment scales in research if proper comparisons of treatments for the Alcohol-Withdrawal Syndrome are to be made.
Antonio Mirijello - One of the best experts on this subject based on the ideXlab platform.
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Identification and Management of Alcohol Withdrawal Syndrome
Drugs, 2015Co-Authors: Antonio Mirijello, Cristina D’angelo, Gabriele Vassallo, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni AddoloratoAbstract:Symptoms of Alcohol Withdrawal Syndrome (AWS) may develop within 6–24 h after the abrupt discontinuation or decrease of Alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading, fixed-dose or symptom-triggered) may be chosen on the basis of patient characteristics. Severe Withdrawal could require ICU admission and the use of barbiturates or propofol. Other drugs, such as α_2-agonists (clonidine and dexmetedomidine) and β-blockers can be used as adjunctive treatments to control neuroautonomic hyperactivity. Furthermore, neuroleptic agents can help control hallucinations. Finally, other medications for the treatment for AWS have been investigated with promising results. These include carbamazepine, valproate, sodium oxybate, baclofen, gabapentin and topiramate. The usefulness of these agents are discussed.
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Sodium oxybate in the treatment of Alcohol dependence: from the Alcohol Withdrawal Syndrome to the Alcohol relapse prevention
Expert opinion on pharmacotherapy, 2013Co-Authors: Katrin Skala, Antonio Mirijello, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Gabriele A. Vassallo, Henriette Walter, Otto M. Lesch, Giovanni AddoloratoAbstract:Introduction: Sodium oxybate (SMO) has been shown to be safe and effective in the treatment of patients with Alcohol use disorders (AUDs); it was approved in Italy and Austria for the treatment of Alcohol Withdrawal Syndrome and for relapse prevention. The focus of this review is to discuss the clinical evidence on the therapeutic potential of SMO for AUDs. Areas covered: This review covers the studies in patients with Alcohol Withdrawal Syndrome who received SMO for the treatment of Withdrawal symptoms and the studies in patients with AUDs who received SMO to achieve total Alcohol abstinence, reduction of Alcohol intake, and relapse prevention. Relevant medical literature on SMO was identified by searching databases including MEDLINE and EMBASE (searches last updated 20 September 2013), bibliographies from published literature, clinical trial registries/databases, and websites. Expert opinion: SMO has proved safe and effective in the treatment of Alcohol Withdrawal Syndrome and in the prevention of relap...
Fabio Caputo - One of the best experts on this subject based on the ideXlab platform.
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Identification and Management of Alcohol Withdrawal Syndrome
Drugs, 2015Co-Authors: Antonio Mirijello, Cristina D’angelo, Gabriele Vassallo, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni AddoloratoAbstract:Symptoms of Alcohol Withdrawal Syndrome (AWS) may develop within 6–24 h after the abrupt discontinuation or decrease of Alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading, fixed-dose or symptom-triggered) may be chosen on the basis of patient characteristics. Severe Withdrawal could require ICU admission and the use of barbiturates or propofol. Other drugs, such as α_2-agonists (clonidine and dexmetedomidine) and β-blockers can be used as adjunctive treatments to control neuroautonomic hyperactivity. Furthermore, neuroleptic agents can help control hallucinations. Finally, other medications for the treatment for AWS have been investigated with promising results. These include carbamazepine, valproate, sodium oxybate, baclofen, gabapentin and topiramate. The usefulness of these agents are discussed.
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Sodium oxybate in the treatment of Alcohol dependence: from the Alcohol Withdrawal Syndrome to the Alcohol relapse prevention
Expert opinion on pharmacotherapy, 2013Co-Authors: Katrin Skala, Antonio Mirijello, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Gabriele A. Vassallo, Henriette Walter, Otto M. Lesch, Giovanni AddoloratoAbstract:Introduction: Sodium oxybate (SMO) has been shown to be safe and effective in the treatment of patients with Alcohol use disorders (AUDs); it was approved in Italy and Austria for the treatment of Alcohol Withdrawal Syndrome and for relapse prevention. The focus of this review is to discuss the clinical evidence on the therapeutic potential of SMO for AUDs. Areas covered: This review covers the studies in patients with Alcohol Withdrawal Syndrome who received SMO for the treatment of Withdrawal symptoms and the studies in patients with AUDs who received SMO to achieve total Alcohol abstinence, reduction of Alcohol intake, and relapse prevention. Relevant medical literature on SMO was identified by searching databases including MEDLINE and EMBASE (searches last updated 20 September 2013), bibliographies from published literature, clinical trial registries/databases, and websites. Expert opinion: SMO has proved safe and effective in the treatment of Alcohol Withdrawal Syndrome and in the prevention of relap...
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rapid suppression of Alcohol Withdrawal Syndrome by baclofen
The American Journal of Medicine, 2002Co-Authors: Giovanni Addolorato, Maria De Bernardi, Fabio Caputo, Esmeralda Capristo, Giancarlo Colombo, Luigi Janiri, Roberta Agabio, Gian Luigi Gessa, Giovanni GasbarriniAbstract:Alcohol Withdrawal Syndrome is a distressing and at times life-threatening condition in Alcohol-dependent patients (1). Usually, symptoms develop within 6 –24 hours after the last drink (2). Early symptoms include raised blood pressure and pulse rate, tremor, hyperreflexia, and anxiety with increased irritability. Clinical management is aimed at symptom relief, prevention of seizures and delirium, and a smooth transition to a treatment program to maintain long-term abstinence from Alcohol (3). Benzodiazepines are presently the drug of choice (4). We recently found that baclofen, a -aminobutyric acid (GABA)B receptor agonist used to control spasticity (5), reduced voluntary Alcohol intake in Alcohol-preferring rats (6), as well as Alcohol craving and intake, up to complete Alcohol abstinence, in Alcohol-dependent patients (7). Furthermore, baclofen suppressed the intensity of Alcohol Withdrawal Syndrome in rats who were physically dependent on Alcohol (6). We therefore studied the effects of oral administration of baclofen in patients with severe Alcohol Withdrawal Syndrome.
Anna Ferrulli - One of the best experts on this subject based on the ideXlab platform.
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Identification and Management of Alcohol Withdrawal Syndrome
Drugs, 2015Co-Authors: Antonio Mirijello, Cristina D’angelo, Gabriele Vassallo, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni AddoloratoAbstract:Symptoms of Alcohol Withdrawal Syndrome (AWS) may develop within 6–24 h after the abrupt discontinuation or decrease of Alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading, fixed-dose or symptom-triggered) may be chosen on the basis of patient characteristics. Severe Withdrawal could require ICU admission and the use of barbiturates or propofol. Other drugs, such as α_2-agonists (clonidine and dexmetedomidine) and β-blockers can be used as adjunctive treatments to control neuroautonomic hyperactivity. Furthermore, neuroleptic agents can help control hallucinations. Finally, other medications for the treatment for AWS have been investigated with promising results. These include carbamazepine, valproate, sodium oxybate, baclofen, gabapentin and topiramate. The usefulness of these agents are discussed.
-
Sodium oxybate in the treatment of Alcohol dependence: from the Alcohol Withdrawal Syndrome to the Alcohol relapse prevention
Expert opinion on pharmacotherapy, 2013Co-Authors: Katrin Skala, Antonio Mirijello, Anna Ferrulli, Mariangela Antonelli, Fabio Caputo, Gabriele A. Vassallo, Henriette Walter, Otto M. Lesch, Giovanni AddoloratoAbstract:Introduction: Sodium oxybate (SMO) has been shown to be safe and effective in the treatment of patients with Alcohol use disorders (AUDs); it was approved in Italy and Austria for the treatment of Alcohol Withdrawal Syndrome and for relapse prevention. The focus of this review is to discuss the clinical evidence on the therapeutic potential of SMO for AUDs. Areas covered: This review covers the studies in patients with Alcohol Withdrawal Syndrome who received SMO for the treatment of Withdrawal symptoms and the studies in patients with AUDs who received SMO to achieve total Alcohol abstinence, reduction of Alcohol intake, and relapse prevention. Relevant medical literature on SMO was identified by searching databases including MEDLINE and EMBASE (searches last updated 20 September 2013), bibliographies from published literature, clinical trial registries/databases, and websites. Expert opinion: SMO has proved safe and effective in the treatment of Alcohol Withdrawal Syndrome and in the prevention of relap...
