The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform
Hongwei Zhou - One of the best experts on this subject based on the ideXlab platform.
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metal free synthesis of polyfunctionalized 2 3 dihydropyrroles and furans via the sequence of propargyl allenyl isomerization and alder ene Reaction
Tetrahedron Letters, 2015Co-Authors: Gangdong Xing, Sikai Chen, Hongwei ZhouAbstract:An efficient metal-free procedure for the synthesis of 4-diphenylphosphoryl)methyl-2,3-dihydro-1H-pyrroles and furans was developed via a sequence of propargyl–allenyl isomerization and Alder ene Reaction. The Wittig-type olefination transformation of the phosphine oxide moiety to the vinyl group with high stereoselectivity was further investigated.
Kay M Brummond - One of the best experts on this subject based on the ideXlab platform.
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cycloaddition Reactions of amino acid derived cross conjugated trienes stereoselective synthesis of novel heterocyclic scaffolds
Heterocycles, 2006Co-Authors: Branko Mitasev, Bingli Yan, Kay M BrummondAbstract:Cross-conjugated trienes obtained via a Rh(I)-catalyzed allenic Alder-Ene Reaction represent a new class of compounds. The synthesis of heterocyclic compounds containing multiple fused rings was accomplished via sequential Diels-Alder Reactions of amino-acid derived cross-conjugated trienes. Newly synthesized imino-oxazolidinone fused trienes were used to control the stereoselectivity in an intermolecular cycloaddition sequence. Additionally, intramolecular cycloaddition of ester tethered tetraene stereoselectively afforded fused tricyclic pyridino-pyranone which was effectively utilized in subsequent cycloaddition Reactions.
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a rhodium i catalyzed formal allenic alder ene Reaction for the rapid and stereoselective assembly of cross conjugated trienes
Journal of the American Chemical Society, 2002Co-Authors: Kay M Brummond, Hongfeng Chen, Peter C Sill, Lingfeng YouAbstract:A rhodium(I)-catalyzed allenic Alder ene Reaction to prepare cross-conjugated trienes has been discovered. The scope and limitations are currently being investigated, and the results obtained to date are reported on. This method shows enticing functional group compatibility by tolerating terminal and internal alkynes, hydroxyl, sulfonamide, ether, and diester groups. Progress has been made to increase the stereoselectivity of the olefinic side chain via an unprecendented iridium(I) catalyzed Alder-Ene Reaction.
Lingfeng You - One of the best experts on this subject based on the ideXlab platform.
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a rhodium i catalyzed formal allenic alder ene Reaction for the rapid and stereoselective assembly of cross conjugated trienes
Journal of the American Chemical Society, 2002Co-Authors: Kay M Brummond, Hongfeng Chen, Peter C Sill, Lingfeng YouAbstract:A rhodium(I)-catalyzed allenic Alder ene Reaction to prepare cross-conjugated trienes has been discovered. The scope and limitations are currently being investigated, and the results obtained to date are reported on. This method shows enticing functional group compatibility by tolerating terminal and internal alkynes, hydroxyl, sulfonamide, ether, and diester groups. Progress has been made to increase the stereoselectivity of the olefinic side chain via an unprecendented iridium(I) catalyzed Alder-Ene Reaction.
Gangdong Xing - One of the best experts on this subject based on the ideXlab platform.
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metal free synthesis of polyfunctionalized 2 3 dihydropyrroles and furans via the sequence of propargyl allenyl isomerization and alder ene Reaction
Tetrahedron Letters, 2015Co-Authors: Gangdong Xing, Sikai Chen, Hongwei ZhouAbstract:An efficient metal-free procedure for the synthesis of 4-diphenylphosphoryl)methyl-2,3-dihydro-1H-pyrroles and furans was developed via a sequence of propargyl–allenyl isomerization and Alder ene Reaction. The Wittig-type olefination transformation of the phosphine oxide moiety to the vinyl group with high stereoselectivity was further investigated.
Dillip K Mohanty - One of the best experts on this subject based on the ideXlab platform.
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the Reaction of oximes with 4 phenyl 1 2 4 triazoline 3 5 dione to produce nitric oxide model compounds for nitric oxide synthase
Tetrahedron Letters, 2018Co-Authors: Anton W Jensen, Daryl Flotka, Alexis E Pullizzi, Wendell L Dilling, Joshua C Doverspike, Mark E Meyerhoff, Dillip K MohantyAbstract:Abstract Certain oximes form nitric oxide upon Reaction with 4-phenyl-1,2,4-triazole-3,5-dione (PTAD). The oximes appear to undergo an Alder-Ene Reaction with the PTAD enophile to form a nitroso intermediate capable of dimerization and/or nitric oxide formation. Upon exposure to oxygen, the nitroso compounds eventually form ketones. This Reaction may serve as a model for the study of nitric oxide synthase (NOS), the enzyme responsible for physiological production of nitric oxide. NOS is known to produce an oxime intermediate which reacts with oxygen to produce nitric oxide and citrulline.