The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Michael Tanzer - One of the best experts on this subject based on the ideXlab platform.
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local Alendronic Acid elution increases net periimplant bone formation a micro ct analysis
Clinical Orthopaedics and Related Research, 2014Co-Authors: Dennis J Bobyn, Rebecca Thompson, Letitia Lim, Jenny Ann Pura, Kristian Bobyn, Michael TanzerAbstract:Background Fixation of cementless orthopaedic implants is not always achieved, particularly in challenging scenarios such as revision surgery, trauma, and tumor reconstruction. An adjunct therapy for improving implant fixation would improve the reliability and durability of certain reconstructive procedures.
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erratum to local Alendronic Acid elution increases net periimplant bone formation a micro ct analysis
Clinical Orthopaedics and Related Research, 2014Co-Authors: Dennis J Bobyn, Rebecca Thompson, Letitia Lim, Jenny Ann Pura, Kristian Bobyn, Michael TanzerAbstract:The online version of the original article can be found under doi:10.1007/s11999-013-3120-6.
Dennis J Bobyn - One of the best experts on this subject based on the ideXlab platform.
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local Alendronic Acid elution increases net periimplant bone formation a micro ct analysis
Clinical Orthopaedics and Related Research, 2014Co-Authors: Dennis J Bobyn, Rebecca Thompson, Letitia Lim, Jenny Ann Pura, Kristian Bobyn, Michael TanzerAbstract:Background Fixation of cementless orthopaedic implants is not always achieved, particularly in challenging scenarios such as revision surgery, trauma, and tumor reconstruction. An adjunct therapy for improving implant fixation would improve the reliability and durability of certain reconstructive procedures.
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erratum to local Alendronic Acid elution increases net periimplant bone formation a micro ct analysis
Clinical Orthopaedics and Related Research, 2014Co-Authors: Dennis J Bobyn, Rebecca Thompson, Letitia Lim, Jenny Ann Pura, Kristian Bobyn, Michael TanzerAbstract:The online version of the original article can be found under doi:10.1007/s11999-013-3120-6.
Alison Fletcher - One of the best experts on this subject based on the ideXlab platform.
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effect of denosumab or Alendronic Acid on the progression of aortic stenosis a double blind randomized controlled trial
Circulation, 2021Co-Authors: Tania Pawade, Mhairi K Doris, Rong Bing, Audrey C White, Laura Forsyth, Emily Evans, Catriona Graham, Michelle C Williams, Edwin J R Van Beek, Alison FletcherAbstract:Background: Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone turnover and osteoblastic diffe...
Tania Pawade - One of the best experts on this subject based on the ideXlab platform.
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effect of denosumab or Alendronic Acid on the progression of aortic stenosis a double blind randomized controlled trial
Circulation, 2021Co-Authors: Tania Pawade, Mhairi K Doris, Rong Bing, Audrey C White, Laura Forsyth, Emily Evans, Catriona Graham, Michelle C Williams, Edwin J R Van Beek, Alison FletcherAbstract:Background: Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone turnover and osteoblastic diffe...
Dafang Zhong - One of the best experts on this subject based on the ideXlab platform.
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bioequivalence of generic alendronate sodium tablets 70 mg to fosamax tablets 70 mg in fasting healthy volunteers a randomized open label three way reference replicated crossover study
Drug Design Development and Therapy, 2017Co-Authors: Yifan Zhang, Xiaoyan Chen, Yunbiao Tang, Lixia Guo, Dafang ZhongAbstract:Purpose The aim of this study was to evaluate the bioequivalence of a generic product 70 mg alendronate sodium tablets with the reference product Fosamax® 70 mg tablet. Materials and methods A single-center, open-label, randomized, three-period, three-sequence, reference-replicated crossover study was performed in 36 healthy Chinese male volunteers under fasting conditions. In each study period, the volunteers received a single oral dose of the generic or reference product (70 mg). Blood samples were collected at pre-dose and up to 8 h after administration. The bioequivalence of the generic product to the reference product was assessed using the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) reference-scaled average bioequivalence (RSABE) methods. Results The average maximum concentrations (Cmax) of Alendronic Acid were 64.78±43.76, 56.62±31.95, and 60.15±37.12 ng/mL after the single dose of the generic product and the first and second doses of the reference product, respectively. The areas under the plasma concentration-time curves from time 0 to the last timepoint (AUC0-t ) were 150.36±82.90, 148.15±85.97, and 167.11±110.87 h⋅ng/mL, respectively. Reference scaling was used because the within-subject standard deviations of the reference product (sWR ) for Cmax and AUC0-t were all higher than the cutoff value of 0.294. The 95% upper confidence bounds were -0.16 and -0.17 for Cmax and AUC0-t , respectively, and the point estimates for the generic/reference product ratio were 1.08 and 1.00, which satisfied the RSABE acceptance criteria of the FDA. The 90% CIs for Cmax and AUC0-t were 90.35%-129.04% and 85.31%-117.15%, respectively, which were within the limits of the EMA for the bioequivalence of 69.84%-143.19% and 80.00%-125.00%. Conclusion The generic product was bioequivalent to the reference product in terms of the rate and extent of alendronate absorption after a single 70 mg oral dose under fasting conditions.