The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
аллан герович бениашвили - One of the best experts on this subject based on the ideXlab platform.
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method for producing a solution of Alimemazine Tartrate for injection
2014Co-Authors: маргарита алексеевна морозова, аллан герович бениашвилиAbstract:The invention relates to the fields of the chemical and pharmaceutical industry and medicine and concerns methods for producing formulations of neuroleptics. The present method for producing a solution of Alimemazine Tartrate for injection is characterized in that sodium sulphite and ascorbic acid are dissolved under constant agitation in water for injection having a temperature of 20-25oC, which has been pre-bubbled with carbon dioxide for 15-25 minutes; once said ingredients are fully dissolved, Alimemazine Tartrate is added and the mixture is agitated for 10-20 minutes then filtered by membrane filtration; the resultant solution is packaged in ampoules of light-protective glass using a carbon dioxide gas shield, and the solution is subsequently sterilized at a temperature of 100-105oC for 30 minutes.
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method of obtaining Alimemazine Tartrate solution for introduction by injection
2013Co-Authors: маргарита алексеевна морозова, аллан герович бениашвилиAbstract:FIELD: chemistry. SUBSTANCE: invention represents method of obtaining Alimemazine Tartrate solution for introduction by injection, characterised by the fact that sodium sulfate and ascorbic acid are dissolved with constant mixing in water for injections, which has temperature 20-25°C and was preliminarily bubbled with carbon dioxide for 15-25 minutes, after complete dissolution Alimemazine Tartrate is introduced and mixed for 10-20 minutes, filtered by method of sterilising membrane filtration, obtained solution is packed into dimming glass ampoule with application of gas protection by carbon dioxide with further sterilisation of solution at temperature 100-105°C for 30 minutes. EFFECT: method improvement. 2 cl, 3 ex
маргарита алексеевна морозова - One of the best experts on this subject based on the ideXlab platform.
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method for producing a solution of Alimemazine Tartrate for injection
2014Co-Authors: маргарита алексеевна морозова, аллан герович бениашвилиAbstract:The invention relates to the fields of the chemical and pharmaceutical industry and medicine and concerns methods for producing formulations of neuroleptics. The present method for producing a solution of Alimemazine Tartrate for injection is characterized in that sodium sulphite and ascorbic acid are dissolved under constant agitation in water for injection having a temperature of 20-25oC, which has been pre-bubbled with carbon dioxide for 15-25 minutes; once said ingredients are fully dissolved, Alimemazine Tartrate is added and the mixture is agitated for 10-20 minutes then filtered by membrane filtration; the resultant solution is packaged in ampoules of light-protective glass using a carbon dioxide gas shield, and the solution is subsequently sterilized at a temperature of 100-105oC for 30 minutes.
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method of obtaining Alimemazine Tartrate solution for introduction by injection
2013Co-Authors: маргарита алексеевна морозова, аллан герович бениашвилиAbstract:FIELD: chemistry. SUBSTANCE: invention represents method of obtaining Alimemazine Tartrate solution for introduction by injection, characterised by the fact that sodium sulfate and ascorbic acid are dissolved with constant mixing in water for injections, which has temperature 20-25°C and was preliminarily bubbled with carbon dioxide for 15-25 minutes, after complete dissolution Alimemazine Tartrate is introduced and mixed for 10-20 minutes, filtered by method of sterilising membrane filtration, obtained solution is packed into dimming glass ampoule with application of gas protection by carbon dioxide with further sterilisation of solution at temperature 100-105°C for 30 minutes. EFFECT: method improvement. 2 cl, 3 ex
Jacques Viret - One of the best experts on this subject based on the ideXlab platform.
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A spin label study of the membrane effect of various psychoactive drugs in human erythrocytes.
Life Sciences, 1993Co-Authors: Michel Lejoyeux, D. Daveloose, JEAN CLAUDE MAZIERE, Jean Adès, Jacques ViretAbstract:Abstract The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, Alimemazine Tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation frequency (V + ) of the spin label 16NS has been comparatively investigated in whole human erythrocytes. V + was about 40% increased by the three neuroleptics, the anticholinergic agent and the antidepressant molecules at 0.2mM. By contrast, lithium did not induce any significant change in V + at the same concentrations. It can be suggested that the increase in “membrane fluidity”, observed with a wide variety of drugs, is a non specific effect, unrelated to the psychotropic action, that can be ascribed to the amphiphilic properties of the tested drugs.
Michel Lejoyeux - One of the best experts on this subject based on the ideXlab platform.
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A spin label study of the membrane effect of various psychoactive drugs in human erythrocytes.
Life Sciences, 1993Co-Authors: Michel Lejoyeux, D. Daveloose, JEAN CLAUDE MAZIERE, Jean Adès, Jacques ViretAbstract:Abstract The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, Alimemazine Tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation frequency (V + ) of the spin label 16NS has been comparatively investigated in whole human erythrocytes. V + was about 40% increased by the three neuroleptics, the anticholinergic agent and the antidepressant molecules at 0.2mM. By contrast, lithium did not induce any significant change in V + at the same concentrations. It can be suggested that the increase in “membrane fluidity”, observed with a wide variety of drugs, is a non specific effect, unrelated to the psychotropic action, that can be ascribed to the amphiphilic properties of the tested drugs.
D. Daveloose - One of the best experts on this subject based on the ideXlab platform.
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A spin label study of the membrane effect of various psychoactive drugs in human erythrocytes.
Life Sciences, 1993Co-Authors: Michel Lejoyeux, D. Daveloose, JEAN CLAUDE MAZIERE, Jean Adès, Jacques ViretAbstract:Abstract The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, Alimemazine Tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation frequency (V + ) of the spin label 16NS has been comparatively investigated in whole human erythrocytes. V + was about 40% increased by the three neuroleptics, the anticholinergic agent and the antidepressant molecules at 0.2mM. By contrast, lithium did not induce any significant change in V + at the same concentrations. It can be suggested that the increase in “membrane fluidity”, observed with a wide variety of drugs, is a non specific effect, unrelated to the psychotropic action, that can be ascribed to the amphiphilic properties of the tested drugs.
