The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Chao Wang - One of the best experts on this subject based on the ideXlab platform.

  • Alisma genus phytochemical constituents biosynthesis and biological activities
    Phytotherapy Research, 2021
    Co-Authors: Lei Feng, Chao Wang, Xiaokui Huo, Xiangge Tian, Bao-jing Zhang, Jing Ning, Tiantian Liu, Wenyu Zhao, Chengpeng Sun
    Abstract:

    The genus Alisma contains 11 species distributed worldwide, of which at least two species (A. orientale [Sam.] Juzep. and A. plantago-aquatica Linn.) have been used as common herbal medicines. Secondary metabolites obtained from the genus Alisma are considered to be the material basis for the various biological functions and medicinal applications. In this review, we mainly focused on the recent investigations of secondary metabolites from plants of the genus Alisma and their biological activities, with the highlighting on the diversity of the chemical structures, the biosynthesis of interesting secondary metabolites, the biological activities, and the relationships between structures and bioactivities.

  • chemical constituents from Alisma plantago aquatica subsp orientale sam sam and their anti inflammatory and antioxidant activities
    Natural Product Research, 2018
    Co-Authors: Xinyu Zhao, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Jian-chao Zhao, Chengpeng Sun, Gang Wang, Yan Wang, Chao Wang
    Abstract:

    The chemical constituent investigation of Alisma plantago-aquatica subsp. orientale has led to isolation and identification of thirteen compounds, including one new sesquiterpene, (10S)-11-hydroxy-...

  • A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.
    Natural product research, 2017
    Co-Authors: Ya-li Wang, Chao Wang, Xiaokui Huo, Jia-hao Liang, Xiangge Tian, Bao-jing Zhang, Lei Feng, Jing Ning, Jian-chao Zhao, Gang Chen
    Abstract:

    A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.

  • Alismanin a a triterpenoid with a c34 skeleton from Alisma orientale as a natural agonist of human pregnane x receptor
    Organic Letters, 2017
    Co-Authors: Chao Wang, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Chengpeng Sun, Xinyu Zhao, Zhilin Luan, Fei Cao, Bao-jing Zhang
    Abstract:

    Alismanin A (1), a novel aromatic triterpenoid with a C34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR spectra, electronic circular dichroism (ECD), theoretical calculations, and X-ray diffraction analysis. Compounds 1 and 2 displayed significant activation effects on pregnane X receptor (PXR) at 10 nM. A plausible biosynthetic pathway for 1–3 is also discussed.

  • sesquiterpenes and triterpenoids from the rhizomes of Alisma orientalis and their pancreatic lipase inhibitory activities
    Phytochemistry Letters, 2017
    Co-Authors: Jian Cang, Chao Wang, Xiaokui Huo, Xiangge Tian, Bao-jing Zhang, Chengpeng Sun, Houli Zhang, Sa Deng, Kexin Liu
    Abstract:

    Abstract Five new terpenoids, including three sesquiterpenes 11-hydroxy-8-ox-alismoxide ( 1 ), 11-oxo-13- nor -alismol ( 2 ), and 1β,11-dihydroxy-β-cyperone ( 3 ), and two protostane-type triterpenoids 16β-acetoxy alisol B ( 4 ) and 16α-acetoxy alisol B ( 5 ) were isolated from the rhizomes of Alisma orientalis together with 11 known compounds. Their structures were established using 1D and 2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were assayed for their inhibitory activities against pancreatic lipase. Compounds 6 and 13 showed inhibitory effects with IC 50 values of 64.4 and 45.5 μM, respectively.

Xiangge Tian - One of the best experts on this subject based on the ideXlab platform.

  • Alisma genus phytochemical constituents biosynthesis and biological activities
    Phytotherapy Research, 2021
    Co-Authors: Lei Feng, Chao Wang, Xiaokui Huo, Xiangge Tian, Bao-jing Zhang, Jing Ning, Tiantian Liu, Wenyu Zhao, Chengpeng Sun
    Abstract:

    The genus Alisma contains 11 species distributed worldwide, of which at least two species (A. orientale [Sam.] Juzep. and A. plantago-aquatica Linn.) have been used as common herbal medicines. Secondary metabolites obtained from the genus Alisma are considered to be the material basis for the various biological functions and medicinal applications. In this review, we mainly focused on the recent investigations of secondary metabolites from plants of the genus Alisma and their biological activities, with the highlighting on the diversity of the chemical structures, the biosynthesis of interesting secondary metabolites, the biological activities, and the relationships between structures and bioactivities.

  • chemical constituents from Alisma plantago aquatica subsp orientale sam sam and their anti inflammatory and antioxidant activities
    Natural Product Research, 2018
    Co-Authors: Xinyu Zhao, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Jian-chao Zhao, Chengpeng Sun, Gang Wang, Yan Wang, Chao Wang
    Abstract:

    The chemical constituent investigation of Alisma plantago-aquatica subsp. orientale has led to isolation and identification of thirteen compounds, including one new sesquiterpene, (10S)-11-hydroxy-...

  • two new protostane type triterpenoids from Alisma orientalis
    Natural Product Research, 2018
    Co-Authors: Xiulan Xin, Xiaokui Huo, Xiangge Tian, Chengpeng Sun, Xinyu Zhao, Houli Zhang, Yan Tian, Yong Liu, Xun Wang
    Abstract:

    Two new protostane-type triterpenoids, 17-epi alisolide (1) and 24-epi Alismanol D (2), were isolated from Alisma orientalis together with one known compound. Their structural elucidations were conducted by NMR, UV and HRESIMS spectroscopic analyses, and comparison with the literature data. All the isolated compounds were evaluated for inhibitory effects on HCE-2. Compound 2 displayed moderate inhibitory activity against HCE-2 with IC50 value of 23.1 μM.

  • A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.
    Natural product research, 2017
    Co-Authors: Ya-li Wang, Chao Wang, Xiaokui Huo, Jia-hao Liang, Xiangge Tian, Bao-jing Zhang, Lei Feng, Jing Ning, Jian-chao Zhao, Gang Chen
    Abstract:

    A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.

  • Alismanin a a triterpenoid with a c34 skeleton from Alisma orientale as a natural agonist of human pregnane x receptor
    Organic Letters, 2017
    Co-Authors: Chao Wang, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Chengpeng Sun, Xinyu Zhao, Zhilin Luan, Fei Cao, Bao-jing Zhang
    Abstract:

    Alismanin A (1), a novel aromatic triterpenoid with a C34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR spectra, electronic circular dichroism (ECD), theoretical calculations, and X-ray diffraction analysis. Compounds 1 and 2 displayed significant activation effects on pregnane X receptor (PXR) at 10 nM. A plausible biosynthetic pathway for 1–3 is also discussed.

Xiaokui Huo - One of the best experts on this subject based on the ideXlab platform.

  • Alisma genus phytochemical constituents biosynthesis and biological activities
    Phytotherapy Research, 2021
    Co-Authors: Lei Feng, Chao Wang, Xiaokui Huo, Xiangge Tian, Bao-jing Zhang, Jing Ning, Tiantian Liu, Wenyu Zhao, Chengpeng Sun
    Abstract:

    The genus Alisma contains 11 species distributed worldwide, of which at least two species (A. orientale [Sam.] Juzep. and A. plantago-aquatica Linn.) have been used as common herbal medicines. Secondary metabolites obtained from the genus Alisma are considered to be the material basis for the various biological functions and medicinal applications. In this review, we mainly focused on the recent investigations of secondary metabolites from plants of the genus Alisma and their biological activities, with the highlighting on the diversity of the chemical structures, the biosynthesis of interesting secondary metabolites, the biological activities, and the relationships between structures and bioactivities.

  • chemical constituents from Alisma plantago aquatica subsp orientale sam sam and their anti inflammatory and antioxidant activities
    Natural Product Research, 2018
    Co-Authors: Xinyu Zhao, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Jian-chao Zhao, Chengpeng Sun, Gang Wang, Yan Wang, Chao Wang
    Abstract:

    The chemical constituent investigation of Alisma plantago-aquatica subsp. orientale has led to isolation and identification of thirteen compounds, including one new sesquiterpene, (10S)-11-hydroxy-...

  • two new protostane type triterpenoids from Alisma orientalis
    Natural Product Research, 2018
    Co-Authors: Xiulan Xin, Xiaokui Huo, Xiangge Tian, Chengpeng Sun, Xinyu Zhao, Houli Zhang, Yan Tian, Yong Liu, Xun Wang
    Abstract:

    Two new protostane-type triterpenoids, 17-epi alisolide (1) and 24-epi Alismanol D (2), were isolated from Alisma orientalis together with one known compound. Their structural elucidations were conducted by NMR, UV and HRESIMS spectroscopic analyses, and comparison with the literature data. All the isolated compounds were evaluated for inhibitory effects on HCE-2. Compound 2 displayed moderate inhibitory activity against HCE-2 with IC50 value of 23.1 μM.

  • A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.
    Natural product research, 2017
    Co-Authors: Ya-li Wang, Chao Wang, Xiaokui Huo, Jia-hao Liang, Xiangge Tian, Bao-jing Zhang, Lei Feng, Jing Ning, Jian-chao Zhao, Gang Chen
    Abstract:

    A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.

  • Alismanin a a triterpenoid with a c34 skeleton from Alisma orientale as a natural agonist of human pregnane x receptor
    Organic Letters, 2017
    Co-Authors: Chao Wang, Xiaokui Huo, Xiangge Tian, Lei Feng, Jing Ning, Chengpeng Sun, Xinyu Zhao, Zhilin Luan, Fei Cao, Bao-jing Zhang
    Abstract:

    Alismanin A (1), a novel aromatic triterpenoid with a C34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR spectra, electronic circular dichroism (ECD), theoretical calculations, and X-ray diffraction analysis. Compounds 1 and 2 displayed significant activation effects on pregnane X receptor (PXR) at 10 nM. A plausible biosynthetic pathway for 1–3 is also discussed.

Lei Feng - One of the best experts on this subject based on the ideXlab platform.

Jing Ning - One of the best experts on this subject based on the ideXlab platform.