The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Robert H Grubbs - One of the best experts on this subject based on the ideXlab platform.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, Yeonhee Lim, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-Alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Ying Y Lu, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular “click” coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by “graft-through” ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide−Alkyne cycloaddition (CuAAC) “click-to” coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6−∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically ef...
Jeremiah A Johnson - One of the best experts on this subject based on the ideXlab platform.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, Yeonhee Lim, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-Alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Ying Y Lu, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular “click” coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by “graft-through” ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide−Alkyne cycloaddition (CuAAC) “click-to” coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6−∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically ef...
Jeffrey T Koberstein - One of the best experts on this subject based on the ideXlab platform.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, Yeonhee Lim, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-Alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Ying Y Lu, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular “click” coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by “graft-through” ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide−Alkyne cycloaddition (CuAAC) “click-to” coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6−∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically ef...
M G Finn - One of the best experts on this subject based on the ideXlab platform.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, Yeonhee Lim, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-Alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Ying Y Lu, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular “click” coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by “graft-through” ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide−Alkyne cycloaddition (CuAAC) “click-to” coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6−∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically ef...
Alan O Burts - One of the best experts on this subject based on the ideXlab platform.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, Yeonhee Lim, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-Alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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core clickable peg branch azide bivalent bottle brush polymers by romp grafting through and clicking to
Journal of the American Chemical Society, 2011Co-Authors: Jeremiah A Johnson, Alan O Burts, M G Finn, Jeffrey T Koberstein, Nicholas J Turro, David A Tirrell, Ying Y Lu, Robert H GrubbsAbstract:The combination of highly efficient polymerizations with modular “click” coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by “graft-through” ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide−Alkyne cycloaddition (CuAAC) “click-to” coupling of a photocleavable doxorubicin (DOX)-Alkyne Derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6−∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically ef...