The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Koleka Mlisana - One of the best experts on this subject based on the ideXlab platform.
-
design synthesis and characterization of 1 4 aryl 1 h 1 2 3 triazol 4 yl methyl substituted phenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidine 5 carboxylates against mycobacterium tuberculosis
Drug Design Development and Therapy, 2016Co-Authors: Katharigatta N Venugopala, G Dharma B Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Sree Harsha, Koleka MlisanaAbstract:The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal Alkynyl Group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields. The title compounds 7a-l were evaluated for their in vitro antitubercular activity against H37RV and multidrug-resistant strains of Mycobacterium tuberculosis by resazurin microplate assay plate method and it was found that compound 7d was promising against H37RV and multidrug-resistant strains of M. tuberculosis at 10 and 15 μg/mL, respectively.
Katharigatta N Venugopala - One of the best experts on this subject based on the ideXlab platform.
-
design synthesis and characterization of 1 4 aryl 1 h 1 2 3 triazol 4 yl methyl substituted phenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidine 5 carboxylates against mycobacterium tuberculosis
Drug Design Development and Therapy, 2016Co-Authors: Katharigatta N Venugopala, G Dharma B Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Sree Harsha, Koleka MlisanaAbstract:The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal Alkynyl Group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields. The title compounds 7a-l were evaluated for their in vitro antitubercular activity against H37RV and multidrug-resistant strains of Mycobacterium tuberculosis by resazurin microplate assay plate method and it was found that compound 7d was promising against H37RV and multidrug-resistant strains of M. tuberculosis at 10 and 15 μg/mL, respectively.
G Dharma B Rao - One of the best experts on this subject based on the ideXlab platform.
-
design synthesis and characterization of 1 4 aryl 1 h 1 2 3 triazol 4 yl methyl substituted phenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidine 5 carboxylates against mycobacterium tuberculosis
Drug Design Development and Therapy, 2016Co-Authors: Katharigatta N Venugopala, G Dharma B Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Sree Harsha, Koleka MlisanaAbstract:The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal Alkynyl Group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields. The title compounds 7a-l were evaluated for their in vitro antitubercular activity against H37RV and multidrug-resistant strains of Mycobacterium tuberculosis by resazurin microplate assay plate method and it was found that compound 7d was promising against H37RV and multidrug-resistant strains of M. tuberculosis at 10 and 15 μg/mL, respectively.
Osama I Alwassil - One of the best experts on this subject based on the ideXlab platform.
-
design synthesis and characterization of 1 4 aryl 1 h 1 2 3 triazol 4 yl methyl substituted phenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidine 5 carboxylates against mycobacterium tuberculosis
Drug Design Development and Therapy, 2016Co-Authors: Katharigatta N Venugopala, G Dharma B Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Sree Harsha, Koleka MlisanaAbstract:The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal Alkynyl Group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields. The title compounds 7a-l were evaluated for their in vitro antitubercular activity against H37RV and multidrug-resistant strains of Mycobacterium tuberculosis by resazurin microplate assay plate method and it was found that compound 7d was promising against H37RV and multidrug-resistant strains of M. tuberculosis at 10 and 15 μg/mL, respectively.
Deepak Chopra - One of the best experts on this subject based on the ideXlab platform.
-
design synthesis and characterization of 1 4 aryl 1 h 1 2 3 triazol 4 yl methyl substituted phenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidine 5 carboxylates against mycobacterium tuberculosis
Drug Design Development and Therapy, 2016Co-Authors: Katharigatta N Venugopala, G Dharma B Rao, Subhrajyoti Bhandary, Melendhran Pillay, Deepak Chopra, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Sree Harsha, Koleka MlisanaAbstract:The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal Alkynyl Group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields. The title compounds 7a-l were evaluated for their in vitro antitubercular activity against H37RV and multidrug-resistant strains of Mycobacterium tuberculosis by resazurin microplate assay plate method and it was found that compound 7d was promising against H37RV and multidrug-resistant strains of M. tuberculosis at 10 and 15 μg/mL, respectively.