The Experts below are selected from a list of 373557 Experts worldwide ranked by ideXlab platform
Rachel L. Peters - One of the best experts on this subject based on the ideXlab platform.
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Prevalence and Natural History of Tree Nut Allergy
Annals of Allergy Asthma & Immunology, 2020Co-Authors: Vicki Mcwilliam, Kirsten P. Perrett, Thanh D. Dang, Rachel L. PetersAbstract:Abstract Objective Tree nuts are common causes of food-related allergic reactions and anaphylaxis. Resolution of tree nut Allergy is thought to be low, yet studies of the natural history of tree nut Allergy are limited. This review summarizes the available literature regarding tree nut Allergy prevalence and natural history and discusses emerging diagnostic and prognostic developments that will inform clinical management of tree nut Allergy. Data Sources A comprehensive literature search using PubMed was performed. Study Selections Peer-reviewed publications relating to tree nut Allergy prevalence, resolution, and diagnosis were selected, and findings were summarized using a narrative approach. Results Tree nut Allergy prevalence varies by age, region, and food Allergy definition, and ranges from less than 1% to approximately 3% worldwide. Reports on the natural history of tree nut Allergy data are limited to retrospective clinical data or cross-sectional survey data of self-reported food Allergy, with reported resolution ranging from 9% to 14%. Component-resolved diagnostics and basophil activation testing offer the potential to improve the diagnostic accuracy and predicted prognosis of specific tree nut Allergy, but studies are limited. Conclusion Tree nut Allergy remains an understudied area of food Allergy research with limited region-specific studies based on robust food Allergy measures in population cohorts with longitudinal follow-up. This currently limits our understanding of tree nut Allergy prognosis.
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Patterns of tree nut sensitization and Allergy in the first 6 years of life in a population-based cohort
Journal of Allergy and Clinical Immunology, 2019Co-Authors: Vicki Mcwilliam, Jennifer J Koplin, Shyamali C Dharmage, Annelouise Ponsonby, Mimi L K Tang, Lyle C Gurrin, Kirsten P. Perrett, Rachel L. Peters, Katrina J. Allen, Terence DwyerAbstract:Background Longitudinal population-based data regarding tree nut Allergy are limited. Objectives We sought to determine the population prevalence of tree nut Allergy at age 6 years and explore the relationship between egg and peanut Allergy at age 1 year and development of tree nut Allergy at age 6 years. Methods A population-based sample of 5276 children was recruited at age 1 year and followed up at age 6 years. At age 1 year, allergies to egg and peanut were determined by means of oral food challenge, and parents reported their child's history of reaction to tree nuts. Challenge-confirmed tree nut Allergy was assessed at age 6 years. Results At age 1 year, the prevalence of parent-reported tree nut Allergy was 0.1% (95% CI, 0.04% to 0.2%). Only 18.5% of infants had consumed tree nuts in the first year of life. At age 6 years, challenge-confirmed tree nut Allergy prevalence was 3.3% (95% CI, 2.8% to 4.0%), with cashew the most common (2.7%; 95% CI, 2.2% to 3.3%). Of children with peanut Allergy only at age 1 year, 27% (95% CI, 16.1% to 39.7%) had tree nut Allergy at age 6 years compared with 14% (95% CI, 10.4% to 17.9%) of those with egg Allergy only and 37% (95% CI, 27.2% to 47.4%) of those with both peanut and egg Allergy. Conclusions Tree nut Allergy is uncommon in the first year of life, likely because of limited tree nut consumption. At age 6 years, tree nut Allergy prevalence is similar to peanut Allergy prevalence. More than a third of children with both peanut and egg Allergy in infancy have tree nut Allergy at age 6 years. Understanding how to prevent tree nut Allergy should be an urgent priority for future research.
Mariana Castells - One of the best experts on this subject based on the ideXlab platform.
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Important questions in drug Allergy and hypersensitivity: consensus papers from the 2018 AAAAI/WAO international drug Allergy symposium
World Allergy Organization Journal, 2018Co-Authors: Pascal Demoly, Mariana CastellsAbstract:This article is one of a series of international consensus documents developed from the International Drug Allergy Symposium held at the Joint Congress of the American Academy of Allergy, Asthma & Immunology/World Allergy Organization on March 1, 2018, in Orlando, Florida, USA. The symposium was sponsored by The Journal of Allergy and Clinical Immunology, The Journal of Allergy and Clinical Immunology: In Practice, and The World Allergy Organization Journal and chaired by Mariana Castells, MD, PhD, and Pascal Demoly, MD, PhD.
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important questions in drug Allergy and hypersensitivity consensus papers from the 2018 aaaai wao international drug Allergy symposium
World Allergy Organization Journal, 2018Co-Authors: Pascal Demoly, Mariana CastellsAbstract:This article is one of a series of international consensus documents developed from the International Drug Allergy Symposium held at the Joint Congress of the American Academy of Allergy, Asthma & Immunology/World Allergy Organization on March 1, 2018, in Orlando, Florida, USA. The symposium was sponsored by The Journal of Allergy and Clinical Immunology, The Journal of Allergy and Clinical Immunology: In Practice, and The World Allergy Organization Journal and chaired by Mariana Castells, MD, PhD, and Pascal Demoly, MD, PhD.
Vicki Mcwilliam - One of the best experts on this subject based on the ideXlab platform.
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Prevalence and Natural History of Tree Nut Allergy
Annals of Allergy Asthma & Immunology, 2020Co-Authors: Vicki Mcwilliam, Kirsten P. Perrett, Thanh D. Dang, Rachel L. PetersAbstract:Abstract Objective Tree nuts are common causes of food-related allergic reactions and anaphylaxis. Resolution of tree nut Allergy is thought to be low, yet studies of the natural history of tree nut Allergy are limited. This review summarizes the available literature regarding tree nut Allergy prevalence and natural history and discusses emerging diagnostic and prognostic developments that will inform clinical management of tree nut Allergy. Data Sources A comprehensive literature search using PubMed was performed. Study Selections Peer-reviewed publications relating to tree nut Allergy prevalence, resolution, and diagnosis were selected, and findings were summarized using a narrative approach. Results Tree nut Allergy prevalence varies by age, region, and food Allergy definition, and ranges from less than 1% to approximately 3% worldwide. Reports on the natural history of tree nut Allergy data are limited to retrospective clinical data or cross-sectional survey data of self-reported food Allergy, with reported resolution ranging from 9% to 14%. Component-resolved diagnostics and basophil activation testing offer the potential to improve the diagnostic accuracy and predicted prognosis of specific tree nut Allergy, but studies are limited. Conclusion Tree nut Allergy remains an understudied area of food Allergy research with limited region-specific studies based on robust food Allergy measures in population cohorts with longitudinal follow-up. This currently limits our understanding of tree nut Allergy prognosis.
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Patterns of tree nut sensitization and Allergy in the first 6 years of life in a population-based cohort
Journal of Allergy and Clinical Immunology, 2019Co-Authors: Vicki Mcwilliam, Jennifer J Koplin, Shyamali C Dharmage, Annelouise Ponsonby, Mimi L K Tang, Lyle C Gurrin, Kirsten P. Perrett, Rachel L. Peters, Katrina J. Allen, Terence DwyerAbstract:Background Longitudinal population-based data regarding tree nut Allergy are limited. Objectives We sought to determine the population prevalence of tree nut Allergy at age 6 years and explore the relationship between egg and peanut Allergy at age 1 year and development of tree nut Allergy at age 6 years. Methods A population-based sample of 5276 children was recruited at age 1 year and followed up at age 6 years. At age 1 year, allergies to egg and peanut were determined by means of oral food challenge, and parents reported their child's history of reaction to tree nuts. Challenge-confirmed tree nut Allergy was assessed at age 6 years. Results At age 1 year, the prevalence of parent-reported tree nut Allergy was 0.1% (95% CI, 0.04% to 0.2%). Only 18.5% of infants had consumed tree nuts in the first year of life. At age 6 years, challenge-confirmed tree nut Allergy prevalence was 3.3% (95% CI, 2.8% to 4.0%), with cashew the most common (2.7%; 95% CI, 2.2% to 3.3%). Of children with peanut Allergy only at age 1 year, 27% (95% CI, 16.1% to 39.7%) had tree nut Allergy at age 6 years compared with 14% (95% CI, 10.4% to 17.9%) of those with egg Allergy only and 37% (95% CI, 27.2% to 47.4%) of those with both peanut and egg Allergy. Conclusions Tree nut Allergy is uncommon in the first year of life, likely because of limited tree nut consumption. At age 6 years, tree nut Allergy prevalence is similar to peanut Allergy prevalence. More than a third of children with both peanut and egg Allergy in infancy have tree nut Allergy at age 6 years. Understanding how to prevent tree nut Allergy should be an urgent priority for future research.
Lars K. Poulsen - One of the best experts on this subject based on the ideXlab platform.
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expression of enzymatically inactive wasp venom phospholipase a1 in pichia pastoris
PLOS ONE, 2011Co-Authors: Irina Borodina, Tim Wagner, Maher Abou Hachem, Ib Sondergaard, Bettina M Jensen, Lars K. PoulsenAbstract:Wasp venom Allergy is the most common insect venom Allergy in Europe. It is manifested by large local reaction or anaphylactic shock occurring after a wasp sting. The Allergy can be treated by specific immunotherapy with whole venom extracts. Wasp venom is difficult and costly to obtain and is a subject to composition variation, therefore it can be advantageous to substitute it with a cocktail of recombinant allergens. One of the major venom allergens is phospholipase A1, which so far has been expressed in Escherichia coli and in insect cells. Our aim was to produce the protein in secreted form in yeast Pichia pastoris, which can give high yields of correctly folded protein on defined minimal medium and secretes relatively few native proteins simplifying purification. Residual amounts of enzymatically active phospholipase A1 could be expressed, but the venom protein had a deleterious effect on growth of the yeast cells. To overcome the problem we introduced three different point mutations at the critical points of the active site, where serine137, aspartate165 or histidine229 were replaced by alanine (S137A, D165A and H229A). All the three mutated forms could be expressed in P. pastoris. The H229A mutant did not have any detectable phospholipase A1 activity and was secreted at the level of several mg/L in shake flask culture. The protein was purified by nickel-affinity chromatography and its identity was confirmed by MALDI-TOF mass spectrometry. The protein could bind IgE antibodies from wasp venom allergic patients and could inhibit the binding of wasp venom to IgE antibodies specific for phospholipase A1 as shown by Enzyme Allergo-Sorbent Test (EAST). Moreover, the recombinant protein was allergenic in a biological assay as demonstrated by its capability to induce histamine release of wasp venom-sensitive basophils. The recombinant phospholipase A1 presents a good candidate for wasp venom immunotherapy.
Kirsten P. Perrett - One of the best experts on this subject based on the ideXlab platform.
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Prevalence and Natural History of Tree Nut Allergy
Annals of Allergy Asthma & Immunology, 2020Co-Authors: Vicki Mcwilliam, Kirsten P. Perrett, Thanh D. Dang, Rachel L. PetersAbstract:Abstract Objective Tree nuts are common causes of food-related allergic reactions and anaphylaxis. Resolution of tree nut Allergy is thought to be low, yet studies of the natural history of tree nut Allergy are limited. This review summarizes the available literature regarding tree nut Allergy prevalence and natural history and discusses emerging diagnostic and prognostic developments that will inform clinical management of tree nut Allergy. Data Sources A comprehensive literature search using PubMed was performed. Study Selections Peer-reviewed publications relating to tree nut Allergy prevalence, resolution, and diagnosis were selected, and findings were summarized using a narrative approach. Results Tree nut Allergy prevalence varies by age, region, and food Allergy definition, and ranges from less than 1% to approximately 3% worldwide. Reports on the natural history of tree nut Allergy data are limited to retrospective clinical data or cross-sectional survey data of self-reported food Allergy, with reported resolution ranging from 9% to 14%. Component-resolved diagnostics and basophil activation testing offer the potential to improve the diagnostic accuracy and predicted prognosis of specific tree nut Allergy, but studies are limited. Conclusion Tree nut Allergy remains an understudied area of food Allergy research with limited region-specific studies based on robust food Allergy measures in population cohorts with longitudinal follow-up. This currently limits our understanding of tree nut Allergy prognosis.
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Patterns of tree nut sensitization and Allergy in the first 6 years of life in a population-based cohort
Journal of Allergy and Clinical Immunology, 2019Co-Authors: Vicki Mcwilliam, Jennifer J Koplin, Shyamali C Dharmage, Annelouise Ponsonby, Mimi L K Tang, Lyle C Gurrin, Kirsten P. Perrett, Rachel L. Peters, Katrina J. Allen, Terence DwyerAbstract:Background Longitudinal population-based data regarding tree nut Allergy are limited. Objectives We sought to determine the population prevalence of tree nut Allergy at age 6 years and explore the relationship between egg and peanut Allergy at age 1 year and development of tree nut Allergy at age 6 years. Methods A population-based sample of 5276 children was recruited at age 1 year and followed up at age 6 years. At age 1 year, allergies to egg and peanut were determined by means of oral food challenge, and parents reported their child's history of reaction to tree nuts. Challenge-confirmed tree nut Allergy was assessed at age 6 years. Results At age 1 year, the prevalence of parent-reported tree nut Allergy was 0.1% (95% CI, 0.04% to 0.2%). Only 18.5% of infants had consumed tree nuts in the first year of life. At age 6 years, challenge-confirmed tree nut Allergy prevalence was 3.3% (95% CI, 2.8% to 4.0%), with cashew the most common (2.7%; 95% CI, 2.2% to 3.3%). Of children with peanut Allergy only at age 1 year, 27% (95% CI, 16.1% to 39.7%) had tree nut Allergy at age 6 years compared with 14% (95% CI, 10.4% to 17.9%) of those with egg Allergy only and 37% (95% CI, 27.2% to 47.4%) of those with both peanut and egg Allergy. Conclusions Tree nut Allergy is uncommon in the first year of life, likely because of limited tree nut consumption. At age 6 years, tree nut Allergy prevalence is similar to peanut Allergy prevalence. More than a third of children with both peanut and egg Allergy in infancy have tree nut Allergy at age 6 years. Understanding how to prevent tree nut Allergy should be an urgent priority for future research.
