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Chong-kuei Lii - One of the best experts on this subject based on the ideXlab platform.

  • effects of organosulfur Compounds from garlic oil on the antioxidation system in rat liver and red blood cells
    Food and Chemical Toxicology, 2001
    Co-Authors: Lee-yan Sheen, Hawwen Chen, S J Tsai, Chong-kuei Lii
    Abstract:

    The modulation of garlic oil (GO) and three Allyl Compounds, diAllyl sulfide (DAS), diAllyl disulfide (DADS) and diAllyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48–84%) in red blood cells (P<0.05). DATS displayed a greater enhancement than GO and DADS (P<0.05). Hemolysis induced by tert-butyl hydroperoxide was not suppressed by GO or Allyl Compound treatment although higher GSH content was evident. Hepatic GSH was not influenced by garlic components. In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively). In contrast, GSH reductase and GST activities in the DAS group, either 20 or 80 mg/kg body weight, were similar to the control group. A decrease of GSH peroxidase activity was observed in rats dosed with 80 mg/kg body weight (P<0.05). An increase in GST activity and a decrease in GSH peroxidase activities were also noted in GO-treated rats (P<0.05). In red blood cells, three GSH-related antioxidant enzyme activities were not affected by garlic oil and its organosulfur components. Immunoblot assay showed that, accompanying the increase in hepatic GST activity, GO, DADS, DAS (80 mg/kg body weight) and DATS increased the expression of GST Ya, Yb1 and Yc proteins. Results indicate that GO and three Allyl Compounds play a differential role in modulation of the GSH-related antioxidant system in rat livers and red blood cells.

Lee-yan Sheen - One of the best experts on this subject based on the ideXlab platform.

  • effects of organosulfur Compounds from garlic oil on the antioxidation system in rat liver and red blood cells
    Food and Chemical Toxicology, 2001
    Co-Authors: Lee-yan Sheen, Hawwen Chen, S J Tsai, Chong-kuei Lii
    Abstract:

    The modulation of garlic oil (GO) and three Allyl Compounds, diAllyl sulfide (DAS), diAllyl disulfide (DADS) and diAllyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48–84%) in red blood cells (P<0.05). DATS displayed a greater enhancement than GO and DADS (P<0.05). Hemolysis induced by tert-butyl hydroperoxide was not suppressed by GO or Allyl Compound treatment although higher GSH content was evident. Hepatic GSH was not influenced by garlic components. In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively). In contrast, GSH reductase and GST activities in the DAS group, either 20 or 80 mg/kg body weight, were similar to the control group. A decrease of GSH peroxidase activity was observed in rats dosed with 80 mg/kg body weight (P<0.05). An increase in GST activity and a decrease in GSH peroxidase activities were also noted in GO-treated rats (P<0.05). In red blood cells, three GSH-related antioxidant enzyme activities were not affected by garlic oil and its organosulfur components. Immunoblot assay showed that, accompanying the increase in hepatic GST activity, GO, DADS, DAS (80 mg/kg body weight) and DATS increased the expression of GST Ya, Yb1 and Yc proteins. Results indicate that GO and three Allyl Compounds play a differential role in modulation of the GSH-related antioxidant system in rat livers and red blood cells.

S J Tsai - One of the best experts on this subject based on the ideXlab platform.

  • effects of organosulfur Compounds from garlic oil on the antioxidation system in rat liver and red blood cells
    Food and Chemical Toxicology, 2001
    Co-Authors: Lee-yan Sheen, Hawwen Chen, S J Tsai, Chong-kuei Lii
    Abstract:

    The modulation of garlic oil (GO) and three Allyl Compounds, diAllyl sulfide (DAS), diAllyl disulfide (DADS) and diAllyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48–84%) in red blood cells (P<0.05). DATS displayed a greater enhancement than GO and DADS (P<0.05). Hemolysis induced by tert-butyl hydroperoxide was not suppressed by GO or Allyl Compound treatment although higher GSH content was evident. Hepatic GSH was not influenced by garlic components. In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively). In contrast, GSH reductase and GST activities in the DAS group, either 20 or 80 mg/kg body weight, were similar to the control group. A decrease of GSH peroxidase activity was observed in rats dosed with 80 mg/kg body weight (P<0.05). An increase in GST activity and a decrease in GSH peroxidase activities were also noted in GO-treated rats (P<0.05). In red blood cells, three GSH-related antioxidant enzyme activities were not affected by garlic oil and its organosulfur components. Immunoblot assay showed that, accompanying the increase in hepatic GST activity, GO, DADS, DAS (80 mg/kg body weight) and DATS increased the expression of GST Ya, Yb1 and Yc proteins. Results indicate that GO and three Allyl Compounds play a differential role in modulation of the GSH-related antioxidant system in rat livers and red blood cells.

Hawwen Chen - One of the best experts on this subject based on the ideXlab platform.

  • effects of organosulfur Compounds from garlic oil on the antioxidation system in rat liver and red blood cells
    Food and Chemical Toxicology, 2001
    Co-Authors: Lee-yan Sheen, Hawwen Chen, S J Tsai, Chong-kuei Lii
    Abstract:

    The modulation of garlic oil (GO) and three Allyl Compounds, diAllyl sulfide (DAS), diAllyl disulfide (DADS) and diAllyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48–84%) in red blood cells (P<0.05). DATS displayed a greater enhancement than GO and DADS (P<0.05). Hemolysis induced by tert-butyl hydroperoxide was not suppressed by GO or Allyl Compound treatment although higher GSH content was evident. Hepatic GSH was not influenced by garlic components. In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively). In contrast, GSH reductase and GST activities in the DAS group, either 20 or 80 mg/kg body weight, were similar to the control group. A decrease of GSH peroxidase activity was observed in rats dosed with 80 mg/kg body weight (P<0.05). An increase in GST activity and a decrease in GSH peroxidase activities were also noted in GO-treated rats (P<0.05). In red blood cells, three GSH-related antioxidant enzyme activities were not affected by garlic oil and its organosulfur components. Immunoblot assay showed that, accompanying the increase in hepatic GST activity, GO, DADS, DAS (80 mg/kg body weight) and DATS increased the expression of GST Ya, Yb1 and Yc proteins. Results indicate that GO and three Allyl Compounds play a differential role in modulation of the GSH-related antioxidant system in rat livers and red blood cells.

Bas De Bruin - One of the best experts on this subject based on the ideXlab platform.

  • intervalent bis mu aziridinato m ii m i complexes m rh ir delocalized metallo radicals or delocalized aminyl radicals
    Chemistry: A European Journal, 2008
    Co-Authors: Cristina Tejel, Miguel A Ciriano, Vincenzo Passarelli, Jose A Lopez, Bas De Bruin
    Abstract:

    Reactions of the methoxo complexes [{M([mu-OMe)(cod)}(2)] (cod = 1,5-cyclooctadiene, M=Rh, Ir) with 2,2-dimethylaziridine (Haz) give the mixed-bridged complexes [{M-2(mu-az)([mu-OMe)(cod)(2)}] [(M = Rh, 1; M = Ir, 2). These Compounds are isolated intermediates in the stereospecific synthesis of the amido-bridged complexes [{M(mu-az)(cod)121 (M=Rh, 3; M = Ir, 4). The electrochemical behavior of 3 and 4 in CH2Cl2, and CH3CN is greatly influenced by the solvent. On a preparative scale, the chemical oxidation of 3 and 4 with [FeCp2](+) gives the paramagnetic cationic species [{M([mu-az)(cod)}(2)](+) (M = Rh, [3](+); M = Ir, [4](+)). The Rh complex [3](+) is stable in dichloromethane, whereas the Ir complex [4](+) transforms slowly, but quantitatively, into a 1:1 mixture of the Allyl Compound [(eta 3,eta 2-C8H11)Ir(mu-az)(2)Ir(cod)] ([5](+)) and the hydride Compound [(cod)(H)Ir(mu-az)(2)Ir(cod)] ([6](+)). Addition of small amounts of acetonitrile to dichloromethane solutions of [3](+) and [4](+) triggers a fast disproportionation reaction in both cases to produce equi-molecular amounts of the starting materials 3 and 4 and metal-metal bonded M-II-M-II species. These new Compounds are isolated by oxidation of 3 and 4 with [FeCp2](+) in acetonitrile as the mixed-ligand complexes [(MeCN)(3)M(mu-az)(2)M(NCMe)(cod)]-(PF6)(2) (M = Rh, [8](2+); M = Ir, [9](2+)). The electronic structures of [3](+) and [4](+) have been elucidated through EPR measurements and DFT calculations showing that their unpaired electron is primarily delocalized over the two metal centers, with minor spin densities at the two bridging amido nitrogen groups. The HOMO of 3 and 4 and the SOMO of [3](+) and [4](+) are essentially M-M d-d sigma*-antibonding orbitals, explaining the formation of a net bonding interaction between the metals upon oxidation of 3 and 4. Mechanisms for the observed Allylic H-atom abstraction reactions from the paramagnetic (radical) complexes are proposed.