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Alternate Function

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Pablo Munguia – One of the best experts on this subject based on the ideXlab platform.

  • Thermoregulation as an Alternate Function of the Sexually Dimorphic Fiddler Crab Claw
    The American naturalist, 2011
    Co-Authors: M. Zachary Darnell, Pablo Munguia
    Abstract:

    AbstractFiddler crabs are highly sexually dimorphic. Males possess one small (minor) feeding claw and one greatly enlarged (major) claw; females possess two small claws. The major claw is used to attract mates and for burrow defense, but it is costly for the male to possess. We tested the hypothesis that the major claw also Functions as a thermoregulatory structure, a Function that would allow males to spend a greater amount of time at the surface, foraging and attracting potential mates. Fiddler crabs Uca panacea were exposed to a source of radiant heat and body temperatures were monitored. Four groups of crabs were tested: intact males, males with the minor claw removed, males with the major claw removed, and females. The body temperatures of males without the major claw increased more rapidly and reached higher values than did those of males with the major claw intact, but the results from these animals were similar to those of females. These results support the hypothesized thermoregulatory Function o…

  • Natural History Note Thermoregulation as an Alternate Function of the Sexually Dimorphic Fiddler Crab Claw
    , 2011
    Co-Authors: M. Zachary Darnell, Pablo Munguia
    Abstract:

    Fiddler crabs are highly sexually dimorphic. Males pos- sess one small (minor) feeding claw and one greatly enlarged (major) claw; females possess two small claws. The major claw is used to attract mates and for burrow defense, but it is costly for the male to possess. We tested the hypothesis that the major claw also Functions as a thermoregulatory structure, a Function that would allow males to spend a greater amount of time at the surface, foraging and at- tracting potential mates. Fiddler crabs Uca panacea were exposed to a source of radiant heat and body temperatures were monitored. Four groups of crabs were tested: intact males, males with the minor claw removed, males with the major claw removed, and females. The body temperatures of males without the major claw increased more rapidly and reached higher values than did those of males with the major claw intact, but the results from these animals were similar to those of females. These results support the hypothesized ther- moregulatory Function of the major claw. The major claw may func- tion as a heat sink, transferring heat away from the body and dis- sipating it into the air. Enhanced thermoregulatory ability provided by the major claw may partially ameliorate the energetic costs of possessing such a large claw.

M. Zachary Darnell – One of the best experts on this subject based on the ideXlab platform.

  • Thermoregulation as an Alternate Function of the Sexually Dimorphic Fiddler Crab Claw
    The American naturalist, 2011
    Co-Authors: M. Zachary Darnell, Pablo Munguia
    Abstract:

    AbstractFiddler crabs are highly sexually dimorphic. Males possess one small (minor) feeding claw and one greatly enlarged (major) claw; females possess two small claws. The major claw is used to attract mates and for burrow defense, but it is costly for the male to possess. We tested the hypothesis that the major claw also Functions as a thermoregulatory structure, a Function that would allow males to spend a greater amount of time at the surface, foraging and attracting potential mates. Fiddler crabs Uca panacea were exposed to a source of radiant heat and body temperatures were monitored. Four groups of crabs were tested: intact males, males with the minor claw removed, males with the major claw removed, and females. The body temperatures of males without the major claw increased more rapidly and reached higher values than did those of males with the major claw intact, but the results from these animals were similar to those of females. These results support the hypothesized thermoregulatory Function o…

  • Natural History Note Thermoregulation as an Alternate Function of the Sexually Dimorphic Fiddler Crab Claw
    , 2011
    Co-Authors: M. Zachary Darnell, Pablo Munguia
    Abstract:

    Fiddler crabs are highly sexually dimorphic. Males pos- sess one small (minor) feeding claw and one greatly enlarged (major) claw; females possess two small claws. The major claw is used to attract mates and for burrow defense, but it is costly for the male to possess. We tested the hypothesis that the major claw also Functions as a thermoregulatory structure, a Function that would allow males to spend a greater amount of time at the surface, foraging and at- tracting potential mates. Fiddler crabs Uca panacea were exposed to a source of radiant heat and body temperatures were monitored. Four groups of crabs were tested: intact males, males with the minor claw removed, males with the major claw removed, and females. The body temperatures of males without the major claw increased more rapidly and reached higher values than did those of males with the major claw intact, but the results from these animals were similar to those of females. These results support the hypothesized ther- moregulatory Function of the major claw. The major claw may func- tion as a heat sink, transferring heat away from the body and dis- sipating it into the air. Enhanced thermoregulatory ability provided by the major claw may partially ameliorate the energetic costs of possessing such a large claw.

Suman Kapila – One of the best experts on this subject based on the ideXlab platform.

  • mir300 intervenes smad3 β catenin runx2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis
    Bone, 2021
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p

  • miR300 intervenes Smad3/β-catenin/RunX2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis.
    Bone, 2020
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p

Taruneet Kaur – One of the best experts on this subject based on the ideXlab platform.

  • mir300 intervenes smad3 β catenin runx2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis
    Bone, 2021
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p

  • miR300 intervenes Smad3/β-catenin/RunX2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis.
    Bone, 2020
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p

Rajeev Kapila – One of the best experts on this subject based on the ideXlab platform.

  • mir300 intervenes smad3 β catenin runx2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis
    Bone, 2021
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p

  • miR300 intervenes Smad3/β-catenin/RunX2 crosstalk for therapy with an Alternate Function as indicative biomarker in osteoporosis.
    Bone, 2020
    Co-Authors: Taruneet Kaur, Aijaz A. John, Chandresh Sharma, N.k. Vashisht, Divya Singh, Rajeev Kapila, Suman Kapila
    Abstract:

    Abstract The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast Functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast Functions. Smad3 served as a validated target for miR300, on homology-based computational analysis and experimental testimony, which activates β-catenin, and subsequently potentiates Runx2. The impact of miR300 on the Smad3/β-catenin/Runx2 signaling interactions in the induction of osteoblast differentiation was scrutinized by immunoblotting and in vivo miRNA antagonism. Overexpression of miR300 in the rat calvarial osteoblasts decreases the protein levels of Smad3, β-catenin and Runx2. Besides, in vivo silencing of miR300 in the neonatal pups and adult rats by AntimiR300 abolishes the suppressing action of miR300 on the osteoblast differentiation and expressions of Smad3/β-catenin/Runx2 axis. MicroCT studies showed improved trabecular microarchitecture in the AntimiR300 transfected ovariectomised rat model compared to sham and negative control. Furthermore, expression levels of miR300 were evaluated in serum samples from an independent set of 30 osteoporotic patients followed by a Receiver Operating Characteristic Curve (ROC) based analysis for the diagnostic efficiency of miR300. Interestingly, the results exhibited high levels of miR300 (p