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Md Shahidul Islam - One of the best experts on this subject based on the ideXlab platform.
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fructose fed streptozotocin injected rat an Alternative Model for type 2 diabetes
Pharmacological Reports, 2012Co-Authors: Rachel Dorothy Wilson, Md Shahidul IslamAbstract:The main objective of the study was to develop an Alternative non-genetic rat Model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum, respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection (i.p.) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection (i.p.). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p < 0.05) higher fluid intake, blood glucose, serum lipids, liver glycogen, liver function enzymes and insulin resistance (HOMA-IR) and significantly (p < 0.05) lower body weight, oral glucose tolerance, number of pancreatic β-cells and pancreatic β-cell functions (HOMA-β) of FR10 group demonstrate that the 10% fructose-fed followed by 40 mg/kg of BWSTZ injected rat can be a new and Alternative Model for T2D.
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fructose fed streptozotocin injected rat an Alternative Model for type 2 diabetes
Pharmacological Reports, 2012Co-Authors: Rachel Dorothy Wilson, Md Shahidul IslamAbstract:Abstract The main objective of the study was to develop an Alternative non-genetic rat Model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum , respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection ( ip ) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection ( ip ). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p
Leslie C. Morey - One of the best experts on this subject based on the ideXlab platform.
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psychological assessment with the dsm 5 Alternative Model for personality disorders tradition and innovation
Professional Psychology: Research and Practice, 2017Co-Authors: Mark H Waugh, Leslie C. Morey, Christopher J Hopwood, Aaron L Pincus, Aidan G C WrightAbstract:The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) Section III Alternative Model for Personality Disorders (AMPD; APA, 2013) represents an innovative system for simultaneous psychiatric classification and psychological assessment of personality disorders (PD). The AMPD combines major paradigms of personality assessment and provides an original, heuristic, flexible, and practical framework that enriches clinical thinking and practice. Origins, emerging research, and clinical application of the AMPD for diagnosis and psychological assessment are reviewed. The AMPD integrates assessment and research traditions, facilitates case conceptualization, is easy to learn and use, and assists in providing patient feedback. New as well as existing tests and psychometric methods may be used to operationalize the AMPD for clinical assessments.
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Relating DSM-5 section II and section III personality disorder diagnostic classification systems to treatment planning.
Comprehensive Psychiatry, 2016Co-Authors: Leslie C. Morey, Kathryn T. BensonAbstract:Abstract Background Beginning with DSM-III, the inclusion of a “personality” axis was designed to encourage awareness of personality disorders and the treatment-related implications of individual differences, but since that time there is little accumulated evidence that the personality disorder categories provide substantial treatment-related guidance. The DSM-5 Personality and Personality Disorders Work Group sought to develop an Alternative Model for personality disorder, and this study examined whether this Model is more closely related to clinicians' decision-making processes than the traditional categorical personality disorder diagnoses. Procedures A national sample of 337 clinicians provided complete personality disorder diagnostic information and several treatment-related clinical judgments about one of their patients. Findings The dimensional concepts of the DSM-5 Alternative Model for personality disorders demonstrated stronger relationships than categorical DSM-IV/DSM-5 Section II diagnoses to 10 of 11 clinical judgments regarding differential treatment planning, optimal treatment intensity, and long-term prognosis. Conclusions The constructs of the DSM-5 Alternative Model for personality disorders may provide more clinically useful information for treatment planning than the official categorical personality disorder diagnostic system retained in DSM-5 Section II.
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personality disorders in dsm 5 emerging research on the Alternative Model
Current Psychiatry Reports, 2015Co-Authors: Leslie C. Morey, Kathryn T. Benson, Alexander J BuschAbstract:The current categorical classification of personality disorders, originally introduced in the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), has been found to suffer from numerous shortcomings that hamper its usefulness for research and for clinical application. The Personality and Personality Disorders Work Group for DSM-5 was charged with developing an Alternative Model that would address many of these concerns. The developed Model involved a hybrid dimensional/categorical Model that represented personality disorders as combinations of core impairments in personality functioning with specific configurations of problematic personality traits. The Board of Trustees of the American Psychiatric Association did not accept the Task Force recommendation to implement this novel approach, and thus this Alternative Model was included in Sect. III of the DSM-5 among concepts requiring additional study. This review provides an overview of the emerging research on this Alternative Model, addressing each of the primary components of the Model.
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clinician judgments of clinical utility a comparison of dsm iv tr personality disorders and the Alternative Model for dsm 5 personality disorders
Journal of Abnormal Psychology, 2014Co-Authors: Leslie C. Morey, Andrew E Skodol, John M OldhamAbstract:This study compared the perceived clinical utility of DSM-IV-TR personality disorder diagnoses (retained in DSM-5) with the Alternative Model presented in DSM-5 Section III, using a national sample of clinicians applying both systems to their own patients. A sample of 337 mental health clinicians (26% psychiatrists, 63% psychologists, and 11% other professional disciplines) provided a complete assessment of all personality disorder features listed in DSM-IV-TR and DSM-5 Section III. After applying each diagnostic Model, clinicians evaluated the clinical utility of that Model with respect to communication with patients and with other professionals, comprehensiveness, descriptiveness, ease of use, and utility for treatment planning. These perceptions were compared across DSM-IV-TR and the 3 components of the DSM-5 Section III Model, and between psychiatrists and nonpsychiatrists. Although DSM-IV-TR was seen as easy to use and useful for professional communication, in every other respect the DSM-5 Section III Model was viewed as being equally or more clinically useful than DSM-IV-TR. In particular, the DSM-5 dimensional trait Model was seen as more useful than DSM-IV-TR in 5 of 6 comparisons-by psychiatrists as well as other professionals. Although concerns were expressed about the clinical utility of the DSM-5 personality disorder system during its development, these criticisms were offered without data on the proposed system. The results of this study demonstrate that aside from the current familiarity of the DSM-IV-TR approach, it offers little advantage in perceived clinical utility over the DSM-5 Section III system, whereas the latter is viewed as being more useful in several respects.
Joshua D Miller - One of the best experts on this subject based on the ideXlab platform.
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examining the contribution of perfectionistic traits to the construct validity of the dsm 5 Alternative Model of personality disorder
Journal of Personality Disorders, 2020Co-Authors: Azad Hemmati, Brandon Weiss, Atefeh Mirani, Farzin Rezaei, Joshua D MillerAbstract:Scholars of perfectionism have proposed significant modifications to DSM-5's Alternative Model of personality disorders (AMPD), such that (1) perfectionism be expanded beyond the inclusion of a singular trait-rigid perfectionism-and (2) perfectionistic traits be specified as trait descriptors of personality disorders (PDs) other than obsessive-compulsive PD. In this study, we evaluate these proposals by examining the degree to which (a) perfectionistic traits are already instantiated in Section II and Section III Models of personality pathology; and (b) perfectionistic traits meaningfully augment the construct validity of AMPD PDs. We conducted these approaches in a large sample (N =3D 435) from an Iranian undergraduate population that is atypically found in the literature. Results showed that perfectionistic traits are already fairly well instantiated in Section III Criterion B. Perfectionistic traits minimally improved the construct validity of OCPD, but did not meaningfully do so for other PDs. Future investigation into the clinical utility of perfectionistic traits is needed.
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difficulties with the conceptualization and assessment of criterion a in the dsm 5 Alternative Model of personality disorder a reply to morey 2019
Psychological Assessment, 2019Co-Authors: Chelsea E Sleep, Donald R Lynam, Thomas A Widiger, Michael L Crowe, Joshua D MillerAbstract:The DSM-5 introduced an Alternative Model of personality disorders that is predicated on the presence of personality dysfunction (Criterion A) and pathological personality traits (Criterion B). Recently, a member of the DSM-5 Personality and Personality Disorder Work Group-Morey-published a measure of Criterion A. Our study (Sleep, Lynam, Widiger, Crowe, & Miller, 2019, this issue) examined the performance of Morey's (2017) Levels of Personality Functioning Scale-Self-Report (LFPS-SR) by testing its factor structure, relations with Axis I and II symptoms, and its incremental validity in predicting traditional personality disorders in comparison to Criterion B traits. In his response, Morey raised a number of issues regarding our examination of the LPFS-SR in relation to its factor structure, discriminant validity, and incremental validity. Moreover, he suggested our approach (i.e., pitting Criterion A vs. B) is emblematic of problems in the field that contributed to the relegating of the AMPD to Section III (on emerging measures and Models). In our response, we answer his criticisms. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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examining the relations among the dsm 5 Alternative Model of personality the five factor Model and externalizing and internalizing behavior
Personality Disorders: Theory Research and Treatment, 2017Co-Authors: Chelsea E Sleep, Courtland S Hyatt, Joanna Lamkin, Jessica L Mapleskeller, Joshua D MillerAbstract:Given long-standing criticisms of the DSM's reliance on categorical Models of psychopathology, including the poor reliability and validity of personality-disorder diagnoses, the American Psychiatric Association (APA) published an Alternative Model (AM) of personality disorders in Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA, 2013), which, in part, comprises 5 pathological trait domains based on the 5-factor Model (FFM). However, the empirical profiles and discriminant validity of the AM traits remain in question. We recruited a sample of undergraduates (N = 340) for the current study to compare the relations found between a measure of the DSM-5 AM traits (i.e., the Personality Inventory for DSM-5; PID-5; Krueger, Derringer, Markon, Watson, & Skodol, 2012) and a measure of the FFM (i.e., the International Personality Item Pool; IPIP; Goldberg, 1999) in relation to externalizing and internalizing symptoms. In general, the domains from the 2 measures were significantly related and demonstrated similar patterns of relations with these criteria, such that Antagonism/low Agreeableness and Disinhibition/low Conscientiousness were related to externalizing behaviors, whereas Negative Affectivity/Neuroticism was most significantly related to internalizing symptoms. However, the PID-5 demonstrated large interrelations among its domains and poorer discriminant validity than the IPIP. These results provide additional support that the conception of the trait Model included in the DSM-5 AM is an extension of the FFM, but highlight some of the issues that arise due to the PID-5's more limited discriminant validity. (PsycINFO Database Record
Rachel Dorothy Wilson - One of the best experts on this subject based on the ideXlab platform.
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fructose fed streptozotocin injected rat an Alternative Model for type 2 diabetes
Pharmacological Reports, 2012Co-Authors: Rachel Dorothy Wilson, Md Shahidul IslamAbstract:The main objective of the study was to develop an Alternative non-genetic rat Model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum, respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection (i.p.) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection (i.p.). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p < 0.05) higher fluid intake, blood glucose, serum lipids, liver glycogen, liver function enzymes and insulin resistance (HOMA-IR) and significantly (p < 0.05) lower body weight, oral glucose tolerance, number of pancreatic β-cells and pancreatic β-cell functions (HOMA-β) of FR10 group demonstrate that the 10% fructose-fed followed by 40 mg/kg of BWSTZ injected rat can be a new and Alternative Model for T2D.
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fructose fed streptozotocin injected rat an Alternative Model for type 2 diabetes
Pharmacological Reports, 2012Co-Authors: Rachel Dorothy Wilson, Md Shahidul IslamAbstract:Abstract The main objective of the study was to develop an Alternative non-genetic rat Model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum , respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection ( ip ) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection ( ip ). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p
Kathryn T. Benson - One of the best experts on this subject based on the ideXlab platform.
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Relating DSM-5 section II and section III personality disorder diagnostic classification systems to treatment planning.
Comprehensive Psychiatry, 2016Co-Authors: Leslie C. Morey, Kathryn T. BensonAbstract:Abstract Background Beginning with DSM-III, the inclusion of a “personality” axis was designed to encourage awareness of personality disorders and the treatment-related implications of individual differences, but since that time there is little accumulated evidence that the personality disorder categories provide substantial treatment-related guidance. The DSM-5 Personality and Personality Disorders Work Group sought to develop an Alternative Model for personality disorder, and this study examined whether this Model is more closely related to clinicians' decision-making processes than the traditional categorical personality disorder diagnoses. Procedures A national sample of 337 clinicians provided complete personality disorder diagnostic information and several treatment-related clinical judgments about one of their patients. Findings The dimensional concepts of the DSM-5 Alternative Model for personality disorders demonstrated stronger relationships than categorical DSM-IV/DSM-5 Section II diagnoses to 10 of 11 clinical judgments regarding differential treatment planning, optimal treatment intensity, and long-term prognosis. Conclusions The constructs of the DSM-5 Alternative Model for personality disorders may provide more clinically useful information for treatment planning than the official categorical personality disorder diagnostic system retained in DSM-5 Section II.
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personality disorders in dsm 5 emerging research on the Alternative Model
Current Psychiatry Reports, 2015Co-Authors: Leslie C. Morey, Kathryn T. Benson, Alexander J BuschAbstract:The current categorical classification of personality disorders, originally introduced in the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), has been found to suffer from numerous shortcomings that hamper its usefulness for research and for clinical application. The Personality and Personality Disorders Work Group for DSM-5 was charged with developing an Alternative Model that would address many of these concerns. The developed Model involved a hybrid dimensional/categorical Model that represented personality disorders as combinations of core impairments in personality functioning with specific configurations of problematic personality traits. The Board of Trustees of the American Psychiatric Association did not accept the Task Force recommendation to implement this novel approach, and thus this Alternative Model was included in Sect. III of the DSM-5 among concepts requiring additional study. This review provides an overview of the emerging research on this Alternative Model, addressing each of the primary components of the Model.
