The Experts below are selected from a list of 474 Experts worldwide ranked by ideXlab platform
Yuqi Gao - One of the best experts on this subject based on the ideXlab platform.
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A hypothesis study on a four-period prevention model for high Altitude Disease.
Military Medical Research, 2018Co-Authors: Xian-sheng Liu, Xiang-rong Yang, Lu Liu, Xian-kui Qin, Yuqi GaoAbstract:High Altitude Disease (HAD) can reduce combat effectiveness and damage the health of soldiers at high Altitudes. The objective of this hypothesis study is to build a four-period prevention model for high Altitude Disease that can be applied at high Altitudes of over 3000 m. We divided the time at high Altitude into nine periods, with three stages from the ascent preparation to the descent to the plain, and applied a continuous dynamic and systematic four-period prevention model across the nine periods. Each period of three stages has its own different measures and targets high Altitude health care services for the prevention of high Altitude Disease. A standard four-period prevention model for high Altitude Disease was constructed for the high Altitude health services at the population level. Our hypothesized HAD prevention model represents a continuous dynamic and systematic four-period prevention model across the nine periods. This hypothesis can be tested from three aspects. The first one isassessment of soldiers' operating efficacies. The second is comparison of the long-term high Altitude population health basic data and development and utilization of big data. The third is descent population health status comparative study and historical retrospective study on prevention. As we know, it is necessary to protect soldiers’ health through the ascent and descent. Through the standard four-period model, we can protect soldiers’ health by preventing high Altitude Diseases, screening the susceptible population, securely tracking their location and maintaining soldiers’ health statuses; we also maintain their operational capabilities, eliminate their psychological fears and ease their family troubles.
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ome on the range update on high Altitude acclimatization adaptation and Disease
Molecular BioSystems, 2014Co-Authors: Yongjun Luo, Yuxiao Wang, Yuqi GaoAbstract:The main physiological challenge in high-Altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high Altitudes; the acclimatization process mainly consists of short-term hyperventilation and long-term compensation by increased oxygen uptake, transport, and use due to increased red blood cell mass, myoglobin, and mitochondria. If individuals cannot acclimatize to high Altitude, they may suffer from a high-Altitude Disease, such as acute mountain Disease (AMS), high-Altitude pulmonary edema (HAPE), high-Altitude cerebral edema (HACE) or chronic mountain sickness (CMS). Because some individuals are more susceptible to high Altitude Diseases than others, the incidence of these high-Altitude Diseases is variable and cannot be predicted. Studying “omes” using genomics, proteomics, metabolomics, transcriptomics, lipidomics, immunomics, glycomics and RNomics can help us understand the factors that mediate susceptibility to high Altitude illnesses. Moreover, analysis of the “omes” using a systems biology approach may provide a greater understanding of high-Altitude illness pathogenesis and improve the efficiency of the diagnosis and treatment of high-Altitude illnesses in the future. Below, we summarize the current literature regarding the role of “omes” in high-Altitude acclimatization/adaptation and Disease and discuss key research gaps to better understand the contribution of “omes” to high-Altitude illness susceptibility.
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‘Ome’ on the range: update on high-Altitude acclimatization/adaptation and Disease
Mol. BioSyst., 2014Co-Authors: Yongjun Luo, Yuxiao Wang, Yuqi GaoAbstract:The main physiological challenge in high-Altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high Altitudes; the acclimatization process mainly consists of short-term hyperventilation and long-term compensation by increased oxygen uptake, transport, and use due to increased red blood cell mass, myoglobin, and mitochondria. If individuals cannot acclimatize to high Altitude, they may suffer from a high-Altitude Disease, such as acute mountain Disease (AMS), high-Altitude pulmonary edema (HAPE), high-Altitude cerebral edema (HACE) or chronic mountain sickness (CMS). Because some individuals are more susceptible to high Altitude Diseases than others, the incidence of these high-Altitude Diseases is variable and cannot be predicted. Studying “omes” using genomics, proteomics, metabolomics, transcriptomics, lipidomics, immunomics, glycomics and RNomics can help us understand the factors that mediate susceptibility to high Altitude illnesses. Moreover, analysis of the “omes” using a systems biology approach may provide a greater understanding of high-Altitude illness pathogenesis and improve the efficiency of the diagnosis and treatment of high-Altitude illnesses in the future. Below, we summarize the current literature regarding the role of “omes” in high-Altitude acclimatization/adaptation and Disease and discuss key research gaps to better understand the contribution of “omes” to high-Altitude illness susceptibility.
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Medical continuing education: reform of teaching methods about high Altitude Disease in China.
High Altitude Medicine & Biology, 2013Co-Authors: Yongjun Luo, Qiquan Zhou, Jianjun Huang, Rong Luo, Xiaohong Yang, Yuqi GaoAbstract:Abstract Luo, Yonjun, Qiquan Zhou, Jianjun Huang, Rong Luo, Ziaohong Yang, and Yuqi Gao. Medical continuing education: Reform of teaching methods about high Altitude Disease in China. High Alt Med Biol 14:181–182, 2013.—The purpose of high Altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatment of high Altitude Disease. As such, traditional classroom teaching methods are not useful to them. Training objects, content, and methods should attempt to conduct a variety of teaching practices. Through continuing medical education on high Altitude Disease, the authors seek to change the traditional teaching model away from a single classroom and traditional written examinations to expand trainees' abilities. These innovative methods of training can improve both the qualit...
Yongjun Luo - One of the best experts on this subject based on the ideXlab platform.
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ome on the range update on high Altitude acclimatization adaptation and Disease
Molecular BioSystems, 2014Co-Authors: Yongjun Luo, Yuxiao Wang, Yuqi GaoAbstract:The main physiological challenge in high-Altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high Altitudes; the acclimatization process mainly consists of short-term hyperventilation and long-term compensation by increased oxygen uptake, transport, and use due to increased red blood cell mass, myoglobin, and mitochondria. If individuals cannot acclimatize to high Altitude, they may suffer from a high-Altitude Disease, such as acute mountain Disease (AMS), high-Altitude pulmonary edema (HAPE), high-Altitude cerebral edema (HACE) or chronic mountain sickness (CMS). Because some individuals are more susceptible to high Altitude Diseases than others, the incidence of these high-Altitude Diseases is variable and cannot be predicted. Studying “omes” using genomics, proteomics, metabolomics, transcriptomics, lipidomics, immunomics, glycomics and RNomics can help us understand the factors that mediate susceptibility to high Altitude illnesses. Moreover, analysis of the “omes” using a systems biology approach may provide a greater understanding of high-Altitude illness pathogenesis and improve the efficiency of the diagnosis and treatment of high-Altitude illnesses in the future. Below, we summarize the current literature regarding the role of “omes” in high-Altitude acclimatization/adaptation and Disease and discuss key research gaps to better understand the contribution of “omes” to high-Altitude illness susceptibility.
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‘Ome’ on the range: update on high-Altitude acclimatization/adaptation and Disease
Mol. BioSyst., 2014Co-Authors: Yongjun Luo, Yuxiao Wang, Yuqi GaoAbstract:The main physiological challenge in high-Altitude plateau environments is hypoxia. When people living in a plain environment migrate to the plateau, they face the threat of hypoxia. Most people can acclimatize to high Altitudes; the acclimatization process mainly consists of short-term hyperventilation and long-term compensation by increased oxygen uptake, transport, and use due to increased red blood cell mass, myoglobin, and mitochondria. If individuals cannot acclimatize to high Altitude, they may suffer from a high-Altitude Disease, such as acute mountain Disease (AMS), high-Altitude pulmonary edema (HAPE), high-Altitude cerebral edema (HACE) or chronic mountain sickness (CMS). Because some individuals are more susceptible to high Altitude Diseases than others, the incidence of these high-Altitude Diseases is variable and cannot be predicted. Studying “omes” using genomics, proteomics, metabolomics, transcriptomics, lipidomics, immunomics, glycomics and RNomics can help us understand the factors that mediate susceptibility to high Altitude illnesses. Moreover, analysis of the “omes” using a systems biology approach may provide a greater understanding of high-Altitude illness pathogenesis and improve the efficiency of the diagnosis and treatment of high-Altitude illnesses in the future. Below, we summarize the current literature regarding the role of “omes” in high-Altitude acclimatization/adaptation and Disease and discuss key research gaps to better understand the contribution of “omes” to high-Altitude illness susceptibility.
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Medical continuing education: reform of teaching methods about high Altitude Disease in China.
High Altitude Medicine & Biology, 2013Co-Authors: Yongjun Luo, Qiquan Zhou, Jianjun Huang, Rong Luo, Xiaohong Yang, Yuqi GaoAbstract:Abstract Luo, Yonjun, Qiquan Zhou, Jianjun Huang, Rong Luo, Ziaohong Yang, and Yuqi Gao. Medical continuing education: Reform of teaching methods about high Altitude Disease in China. High Alt Med Biol 14:181–182, 2013.—The purpose of high Altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatment of high Altitude Disease. As such, traditional classroom teaching methods are not useful to them. Training objects, content, and methods should attempt to conduct a variety of teaching practices. Through continuing medical education on high Altitude Disease, the authors seek to change the traditional teaching model away from a single classroom and traditional written examinations to expand trainees' abilities. These innovative methods of training can improve both the qualit...
Pla Tibet - One of the best experts on this subject based on the ideXlab platform.
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On-Site Treatment of Large Crowds of Severe Acute Mountain Sickness with Acute Exposure to High Altitude Environment
2010Co-Authors: Pla TibetAbstract:Objectives:To explore the measurement of on-site first aid of severe acute Altitude illness in large crowds under acute exposure to high Altitude environment.Methods:18 patients who suffered from severe acute Altitude illness,including high Altitude pulmonary edema (17 cases) and cerebral edema (1 case),between 4 and 48 hours after arrival the Yushu earthquake area were treated at on-site,and the assessment of measurement and efficacy of treatment were conducted.Results:17 of 18 patients with severe acute Altitude illness were cured (17 vs 18,94.44%); 1 patient was transferred after improvement of patient's condition,all patients survived. Conclusions: The general treatment associated with emergency treatment plays an important role on the severe acute high Altitude Disease caused by acute high Altitude hypoxia,and can elevate the cure rate of high Altitude Disease,lowering death,at on-site in large crowds of acute exposure to high Altitude environment.
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Effect of Step-Altitude Acclimatization on Prevention of Acute Severe Altitude Sickness in Construction of Qinghai-Tibet Railway
Occupation and Health, 2010Co-Authors: Zheng Jian-bao, Pla TibetAbstract:[Objective]To understand the effect of step-Altitude acclimatization on prevention of acute severe Altitude sickness (high Altitude pulmonary edema and high Altitude cerebral edema).[Methods]From mid-March to mid-October 2003,the incidence of acute severe high Altitude Disease among 22,200 workers in the construction of Qinghai-Tibet Railway of Tibet section (Tanggula pass to Lhasa of Tibet) were investigated. The incidence of people with different forms into plateau was compared,The incidence of people with ladder mode into the plateau was analyzed.[Results]During 7 months in 2003,a total of 22 200 workers accessed to Tibet section of Qinghai-Tibet Railway;184 cases of high Altitude pulmonary edema occurred (180male cases,4 female cases,aged 20～45 years),and 155 cases of high Altitude cerebral edema (all male cases,aged 22~44 years). The incidence was 0.83% and 0.70%,respectively. Compared workers with step-Altitude acclimatization with workers without acclimatization located in the same Altitude,the incidence of the former was significantly lower than the latter.[Conclusion]The incidence of acute severe Altitude sickness increases with the higher elevation. When large scale people entering plateau areas from plain,using the step-Altitude acclimatization can effectively reduce the incidence of acute severe high Altitude Disease;and as for radical access to plateau by large crowds,the establishment of acclimatization station at an Altitude of 2,500 meters,may be a better approach.
Wang Zheng - One of the best experts on this subject based on the ideXlab platform.
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Development of healthy emergency management system on Qinghai-Tibet Railway
Journal of Suzhou University of Science and Technology, 2010Co-Authors: Wang ZhengAbstract:According to the orient-object software engineering,RUP(Rational Unified Process) and the technology about Web development,this paper builds the system with N-Tier distributed systems structure in JAVA language and AJAX,based on the studies of requirement analysis,architecture and function.The system assesses the health of the workers using the rules from the Expert System by the management of checkup data of staff on Qinghai-Tibet Railway.The probability is also predicted that each worker may get the high Altitude Disease if the work group is a dangerous group.Besides the functions above,the system investigates the distribution of hospitals or iatrical equipments and realizes the optimal operation when the patients occur to ensure the health of staff on the Qinghai-Tibet Railway.
Luo Yongjun - One of the best experts on this subject based on the ideXlab platform.
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High Altitude Pulmonary Edema
Lung Diseases - Selected State of the Art Reviews, 2012Co-Authors: Zhou Qiquan, Luo YongjunAbstract:High Altitude pulmonary edema (HAPE) is a form of high Altitude idiopathy that occurs in a minority of people upon either the first or subsequent exposure to high Altitudes. It is triggered by a shortage of oxygen and certain other predisposing factors, all of which lead to a sudden increase in pulmonary arterial pressure, increase in lung blood volume, disturbance of pulmonary circulation, and leakage of fluid in microcirculation into the pulmonary interstitium and alveoli. The clinical symptoms of this condition include dyspnea and hacking cough. HAPE is a severe type of acute high Altitude Disease, typically occurring at Altitudes above 4,000 meters. However, cases have been reported at Altitudes as low as 2,261 meters in Xining, China. HAPE is a rapid-onset condition that can progress and change quickly, especially during the first stage of high Altitude exposure, usually within a week, peaking within three days. According to a report based on 332 cases, 63% of HAPE patients presented symptoms within three days, and the fastest onset was after only a few hours. HAPE occurs mostly in unacclimatized sea-level residents when they first ascend to high Altitudes or acclimatized individuals ascending from lower to higher Altitudes. It can also occur in long-term high Altitude residents or high Altitude natives undertaking excessive physical activities or in those who return to high Altitudes after living in low-Altitude areas for a period of time. HAPE patients can recover after short-term treatment and continue to stay at high Altitudes. However, improper treatment may lead to negative effects. The incidence rate is closely related to the Altitude, rapidity of exposure, season, the individual’s physical condition, and the intensity of activity.
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A survey of acute mountain sickness and vital signs in subjects ascending to Lhasa via the Qinghai-Tibet train
Scientific Research and Essays, 2011Co-Authors: Luo Yongjun, Zhou Qiquan, Hou XianhuaAbstract:1 Department of High Altitude Disease, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China. 2 Key Laboratory of High Altitude Medicine, Ministry of Education, Third Military Medical University, Chongqing 400038, China. 3 Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
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Epidemiological study of mountain sickness complicated with multiple organ dysfunction syndrome on the Qinghai-Tibetan Plateau: report of 103 cases.
Scientific Research and Essays, 2010Co-Authors: Zhou Qiquan, Luo Yongjun, Li Hong, Li Suzhi, Zhang Xizhou, Gao Wei, Zheng Bihai, Yang Dingzhou, Liu FuyuAbstract:Department of High Altitude Disease, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China. Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China. Department of Mountain Sickness, General Hospital of Tibet Military Command of the Chinese PLA, Lhasa 850003, P. R. China. Institute of High Altitude Diseases; the 18th Hospital of the Chinese PLA, Yecheng 844900, Xinjiang Uygur Autonomous Region, China. Laboratory of Thoracic Surgery, General Hospital of Lanzhou Military Command of the Chinese PLA, Lanzhou 730070, China.